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Cerebral Hyperperfusion Syndrome

MedGen UID:
1758700
•Concept ID:
C1611713
•
Disease or Syndrome

Definition

Unexpected increase in cerebral blood flow after carotid endarterectomy or carotid artery stenting presenting with a clinical triad of ipsilateral headache, seizure and focal neurologic symptoms. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral Hyperperfusion Syndrome

Professional guidelines

PubMed

Treatment Strategy for Progressive Cervical Internal Carotid Artery Stenosis Under Restriction of the Use of Antiplatelet Drugs.
Matsumoto A, Kawai N, Yabuno S, Hirashita K, Yunoki M, Yoshino K
World Neurosurg 2019 Oct;130:e438-e443. Epub 2019 Jun 24 doi: 10.1016/j.wneu.2019.06.111. PMID: 31247349
Intracranial hemorrhage and hyperperfusion syndrome following carotid artery stenting: risk factors, prevention, and treatment.
Abou-Chebl A, Yadav JS, Reginelli JP, Bajzer C, Bhatt D, Krieger DW
J Am Coll Cardiol 2004 May 5;43(9):1596-601. doi: 10.1016/j.jacc.2003.12.039. PMID: 15120817

Recent clinical studies

Etiology

Risk Factors for Cerebral Hyperperfusion Syndrome following Carotid Revascularization.
Hsu AC, Williams B, Ding L, Weaver FA, Han SM, Magee GA
Ann Vasc Surg 2023 Nov;97:89-96. Epub 2023 Jun 24 doi: 10.1016/j.avsg.2023.06.006. PMID: 37356658
Update on cerebral hyperperfusion syndrome.
Lin YH, Liu HM
J Neurointerv Surg 2020 Aug;12(8):788-793. Epub 2020 May 15 doi: 10.1136/neurintsurg-2019-015621. PMID: 32414892Free PMC Article
Cerebral Hyperperfusion Syndrome After Carotid Revascularization and Acute Ischemic Stroke.
Kirchoff-Torres KF, Bakradze E
Curr Pain Headache Rep 2018 Mar 19;22(4):24. doi: 10.1007/s11916-018-0678-4. PMID: 29556806
Cerebral hyperperfusion syndrome and intracranial hemorrhage after carotid endarterectomy or carotid stenting: A meta-analysis.
Galyfos G, Sianou A, Filis K
J Neurol Sci 2017 Oct 15;381:74-82. Epub 2017 Aug 18 doi: 10.1016/j.jns.2017.08.020. PMID: 28991720
Cerebral hyperperfusion syndrome.
van Mook WN, Rennenberg RJ, Schurink GW, van Oostenbrugge RJ, Mess WH, Hofman PA, de Leeuw PW
Lancet Neurol 2005 Dec;4(12):877-88. doi: 10.1016/S1474-4422(05)70251-9. PMID: 16297845

Diagnosis

Cerebrovacular Reserve Predicts the Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy.
Manojlovic V, Budakov N, Budinski S, Milosevic D, Nikolic D, Manojlovic V
J Stroke Cerebrovasc Dis 2020 Dec;29(12):105318. Epub 2020 Sep 22 doi: 10.1016/j.jstrokecerebrovasdis.2020.105318. PMID: 32992180
Update on cerebral hyperperfusion syndrome.
Lin YH, Liu HM
J Neurointerv Surg 2020 Aug;12(8):788-793. Epub 2020 May 15 doi: 10.1136/neurintsurg-2019-015621. PMID: 32414892Free PMC Article
Cerebral Hyperperfusion Syndrome After Carotid Revascularization and Acute Ischemic Stroke.
Kirchoff-Torres KF, Bakradze E
Curr Pain Headache Rep 2018 Mar 19;22(4):24. doi: 10.1007/s11916-018-0678-4. PMID: 29556806
Role of transcranial Doppler in cerebral hyperperfusion syndrome.
Pennekamp CW, Moll FL, De Borst GJ
J Cardiovasc Surg (Torino) 2012 Dec;53(6):765-71. PMID: 23207559
Cerebral hyperperfusion syndrome after carotid intervention: a review.
Lieb M, Shah U, Hines GL
Cardiol Rev 2012 Mar-Apr;20(2):84-9. doi: 10.1097/CRD.0b013e318237eef8. PMID: 22183061

Therapy

Risk Factors for Cerebral Hyperperfusion Syndrome following Carotid Revascularization.
Hsu AC, Williams B, Ding L, Weaver FA, Han SM, Magee GA
Ann Vasc Surg 2023 Nov;97:89-96. Epub 2023 Jun 24 doi: 10.1016/j.avsg.2023.06.006. PMID: 37356658
Update on cerebral hyperperfusion syndrome.
Lin YH, Liu HM
J Neurointerv Surg 2020 Aug;12(8):788-793. Epub 2020 May 15 doi: 10.1136/neurintsurg-2019-015621. PMID: 32414892Free PMC Article
Cerebral Hyperperfusion Syndrome After Carotid Revascularization and Acute Ischemic Stroke.
Kirchoff-Torres KF, Bakradze E
Curr Pain Headache Rep 2018 Mar 19;22(4):24. doi: 10.1007/s11916-018-0678-4. PMID: 29556806
Hypertension and the post-carotid endarterectomy cerebral hyperperfusion syndrome.
Bouri S, Thapar A, Shalhoub J, Jayasooriya G, Fernando A, Franklin IJ, Davies AH
Eur J Vasc Endovasc Surg 2011 Feb;41(2):229-37. Epub 2010 Dec 4 doi: 10.1016/j.ejvs.2010.10.016. PMID: 21131217
Cerebral hyperperfusion syndrome.
van Mook WN, Rennenberg RJ, Schurink GW, van Oostenbrugge RJ, Mess WH, Hofman PA, de Leeuw PW
Lancet Neurol 2005 Dec;4(12):877-88. doi: 10.1016/S1474-4422(05)70251-9. PMID: 16297845

Prognosis

Cerebrovacular Reserve Predicts the Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy.
Manojlovic V, Budakov N, Budinski S, Milosevic D, Nikolic D, Manojlovic V
J Stroke Cerebrovasc Dis 2020 Dec;29(12):105318. Epub 2020 Sep 22 doi: 10.1016/j.jstrokecerebrovasdis.2020.105318. PMID: 32992180
Intracerebral hemorrhage as a manifestation of cerebral hyperperfusion syndrome after carotid revascularization: systematic review and meta-analysis.
Abreu P, Nogueira J, Rodrigues FB, Nascimento A, Carvalho M, Marreiros A, Nzwalo H
Acta Neurochir (Wien) 2017 Nov;159(11):2089-2097. Epub 2017 Sep 15 doi: 10.1007/s00701-017-3328-4. PMID: 28916863
The Susceptibility Pathogenesis of Moyamoya Disease.
Hu J, Luo J, Chen Q
World Neurosurg 2017 May;101:731-741. Epub 2017 Jan 31 doi: 10.1016/j.wneu.2017.01.083. PMID: 28153617
Cerebral hyperperfusion syndrome after revascularization surgery in patients with moyamoya disease.
Zhao WG, Luo Q, Jia JB, Yu JL
Br J Neurosurg 2013 Jun;27(3):321-5. Epub 2013 Mar 5 doi: 10.3109/02688697.2012.757294. PMID: 23461748
Role of transcranial Doppler in cerebral hyperperfusion syndrome.
Pennekamp CW, Moll FL, De Borst GJ
J Cardiovasc Surg (Torino) 2012 Dec;53(6):765-71. PMID: 23207559

Clinical prediction guides

Multidelay MR Arterial Spin Labeling Perfusion Map for the Prediction of Cerebral Hyperperfusion After Carotid Endarterectomy.
Fan X, Lai Z, Lin T, Li K, Hou B, You H, Wei J, Qu J, Liu B, Zuo Z, Feng F
J Magn Reson Imaging 2023 Oct;58(4):1245-1255. Epub 2023 Mar 23 doi: 10.1002/jmri.28634. PMID: 36951494
Cerebrovacular Reserve Predicts the Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy.
Manojlovic V, Budakov N, Budinski S, Milosevic D, Nikolic D, Manojlovic V
J Stroke Cerebrovasc Dis 2020 Dec;29(12):105318. Epub 2020 Sep 22 doi: 10.1016/j.jstrokecerebrovasdis.2020.105318. PMID: 32992180
Prediction of Cerebral Hyperperfusion Syndrome with Velocity Blood Pressure Index.
Lai ZC, Liu B, Chen Y, Ni L, Liu CW
Chin Med J (Engl) 2015 Jun 20;128(12):1611-7. doi: 10.4103/0366-6999.158317. PMID: 26063363Free PMC Article
Role of transcranial Doppler in cerebral hyperperfusion syndrome.
Pennekamp CW, Moll FL, De Borst GJ
J Cardiovasc Surg (Torino) 2012 Dec;53(6):765-71. PMID: 23207559
Hyperperfusion syndrome after carotid revascularization.
Moulakakis KG, Mylonas SN, Sfyroeras GS, Andrikopoulos V
J Vasc Surg 2009 Apr;49(4):1060-8. Epub 2009 Feb 26 doi: 10.1016/j.jvs.2008.11.026. PMID: 19249185

Recent systematic reviews

Cerebral Hyperperfusion Syndrome After Revascularization Surgery in Patients with Moyamoya Disease: Systematic Review and Meta-Analysis.
Yu J, Zhang J, Li J, Zhang J, Chen J
World Neurosurg 2020 Mar;135:357-366.e4. Epub 2019 Nov 20 doi: 10.1016/j.wneu.2019.11.065. PMID: 31759149
Editor's Choice - Cerebral Hyperperfusion Syndrome After Carotid Artery Stenting: A Systematic Review and Meta-analysis.
Huibers AE, Westerink J, de Vries EE, Hoskam A, den Ruijter HM, Moll FL, de Borst GJ
Eur J Vasc Endovasc Surg 2018 Sep;56(3):322-333. Epub 2018 Jun 29 doi: 10.1016/j.ejvs.2018.05.012. PMID: 30196814
Cerebral hyperperfusion syndrome and intracranial hemorrhage after carotid endarterectomy or carotid stenting: A meta-analysis.
Galyfos G, Sianou A, Filis K
J Neurol Sci 2017 Oct 15;381:74-82. Epub 2017 Aug 18 doi: 10.1016/j.jns.2017.08.020. PMID: 28991720
Intracerebral hemorrhage as a manifestation of cerebral hyperperfusion syndrome after carotid revascularization: systematic review and meta-analysis.
Abreu P, Nogueira J, Rodrigues FB, Nascimento A, Carvalho M, Marreiros A, Nzwalo H
Acta Neurochir (Wien) 2017 Nov;159(11):2089-2097. Epub 2017 Sep 15 doi: 10.1007/s00701-017-3328-4. PMID: 28916863
Hypertension and the post-carotid endarterectomy cerebral hyperperfusion syndrome.
Bouri S, Thapar A, Shalhoub J, Jayasooriya G, Fernando A, Franklin IJ, Davies AH
Eur J Vasc Endovasc Surg 2011 Feb;41(2):229-37. Epub 2010 Dec 4 doi: 10.1016/j.ejvs.2010.10.016. PMID: 21131217

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