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Increased risk of AML

MedGen UID:
1759111
•Concept ID:
C5435576
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk of AML

Professional guidelines

PubMed

Treatment-related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms.
Björkholm M, Derolf AR, Hultcrantz M, Kristinsson SY, Ekstrand C, Goldin LR, Andreasson B, Birgegård G, Linder O, Malm C, Markevärn B, Nilsson L, Samuelsson J, Granath F, Landgren O
J Clin Oncol 2011 Jun 10;29(17):2410-5. Epub 2011 May 2 doi: 10.1200/JCO.2011.34.7542. PMID: 21537037Free PMC Article
Risk for the development of treatment-related acute myelocytic leukemia and myelodysplastic syndrome among patients with breast cancer: review of the literature and the National Surgical Adjuvant Breast and Bowel Project experience.
Smith RE
Clin Breast Cancer 2003 Oct;4(4):273-9. doi: 10.3816/cbc.2003.n.032. PMID: 14651772
Risk of acute myelogenous leukaemia and myelodysplasia following cancer treatment.
van Leeuwen FE
Baillieres Clin Haematol 1996 Mar;9(1):57-85. doi: 10.1016/s0950-3536(96)80037-0. PMID: 8730551

Recent clinical studies

Etiology

An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.
Lasry A, Nadorp B, Fornerod M, Nicolet D, Wu H, Walker CJ, Sun Z, Witkowski MT, Tikhonova AN, Guillamot-Ruano M, Cayanan G, Yeaton A, Robbins G, Obeng EA, Tsirigos A, Stone RM, Byrd JC, Pounds S, Carroll WL, Gruber TA, Eisfeld AK, Aifantis I
Nat Cancer 2023 Jan;4(1):27-42. Epub 2022 Dec 29 doi: 10.1038/s43018-022-00480-0. PMID: 36581735Free PMC Article
Updates in infection risk and management in acute leukemia.
Logan C, Koura D, Taplitz R
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):135-139. doi: 10.1182/hematology.2020000098. PMID: 33275701Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Prediction of acute myeloid leukaemia risk in healthy individuals.
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI
Nature 2018 Jul;559(7714):400-404. Epub 2018 Jul 9 doi: 10.1038/s41586-018-0317-6. PMID: 29988082Free PMC Article
Hematopoietic stem cell transplantation for acute myeloid leukemia.
Takami A
Int J Hematol 2018 May;107(5):513-518. Epub 2018 Jan 27 doi: 10.1007/s12185-018-2412-8. PMID: 29374826

Diagnosis

Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
How I investigate acute myeloid leukemia.
Narayanan D, Weinberg OK
Int J Lab Hematol 2020 Feb;42(1):3-15. Epub 2019 Dec 10 doi: 10.1111/ijlh.13135. PMID: 31820579
Prediction of acute myeloid leukaemia risk in healthy individuals.
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI
Nature 2018 Jul;559(7714):400-404. Epub 2018 Jul 9 doi: 10.1038/s41586-018-0317-6. PMID: 29988082Free PMC Article

Therapy

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Updates in infection risk and management in acute leukemia.
Logan C, Koura D, Taplitz R
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):135-139. doi: 10.1182/hematology.2020000098. PMID: 33275701Free PMC Article
Decitabine/Cedazuridine: First Approval.
Dhillon S
Drugs 2020 Sep;80(13):1373-1378. doi: 10.1007/s40265-020-01389-7. PMID: 32860582Free PMC Article
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Hematopoietic stem cell transplantation for acute myeloid leukemia.
Takami A
Int J Hematol 2018 May;107(5):513-518. Epub 2018 Jan 27 doi: 10.1007/s12185-018-2412-8. PMID: 29374826

Prognosis

An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia.
Lasry A, Nadorp B, Fornerod M, Nicolet D, Wu H, Walker CJ, Sun Z, Witkowski MT, Tikhonova AN, Guillamot-Ruano M, Cayanan G, Yeaton A, Robbins G, Obeng EA, Tsirigos A, Stone RM, Byrd JC, Pounds S, Carroll WL, Gruber TA, Eisfeld AK, Aifantis I
Nat Cancer 2023 Jan;4(1):27-42. Epub 2022 Dec 29 doi: 10.1038/s43018-022-00480-0. PMID: 36581735Free PMC Article
Myelodysplastic Syndromes: A New Decade.
Volpe VO, Garcia-Manero G, Komrokji RS
Clin Lymphoma Myeloma Leuk 2022 Jan;22(1):1-16. Epub 2021 Aug 2 doi: 10.1016/j.clml.2021.07.031. PMID: 34544674
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763
Prediction of acute myeloid leukaemia risk in healthy individuals.
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao Z, Cirlan I, Pugh TJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI
Nature 2018 Jul;559(7714):400-404. Epub 2018 Jul 9 doi: 10.1038/s41586-018-0317-6. PMID: 29988082Free PMC Article
Glyphosate Use and Cancer Incidence in the Agricultural Health Study.
Andreotti G, Koutros S, Hofmann JN, Sandler DP, Lubin JH, Lynch CF, Lerro CC, De Roos AJ, Parks CG, Alavanja MC, Silverman DT, Beane Freeman LE
J Natl Cancer Inst 2018 May 1;110(5):509-516. doi: 10.1093/jnci/djx233. PMID: 29136183Free PMC Article

Clinical prediction guides

Myelodysplastic syndromes.
Li H, Hu F, Gale RP, Sekeres MA, Liang Y
Nat Rev Dis Primers 2022 Nov 17;8(1):74. doi: 10.1038/s41572-022-00402-5. PMID: 36396662
Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Myelodysplastic Syndromes: A New Decade.
Volpe VO, Garcia-Manero G, Komrokji RS
Clin Lymphoma Myeloma Leuk 2022 Jan;22(1):1-16. Epub 2021 Aug 2 doi: 10.1016/j.clml.2021.07.031. PMID: 34544674
Chronic myelomonocytic leukemia diagnosis and management.
Chan O, Renneville A, Padron E
Leukemia 2021 Jun;35(6):1552-1562. Epub 2021 Mar 13 doi: 10.1038/s41375-021-01207-3. PMID: 33714974
Myelodysplastic syndromes: 2021 update on diagnosis, risk stratification and management.
Garcia-Manero G, Chien KS, Montalban-Bravo G
Am J Hematol 2020 Nov;95(11):1399-1420. doi: 10.1002/ajh.25950. PMID: 32744763

Recent systematic reviews

Impact of enteral immunonutrition on infectious complications and immune and inflammatory markers in cancer patients undergoing chemotherapy: A systematic review of randomised controlled trials.
Miller LJ, Douglas C, McCullough FS, Stanworth SJ, Calder PC
Clin Nutr 2022 Oct;41(10):2135-2146. Epub 2022 Aug 10 doi: 10.1016/j.clnu.2022.07.039. PMID: 36067585
The efficacy and adverse events of venetoclax in combination with hypomethylating agents treatment for patients with acute myeloid leukemia and myelodysplastic syndrome: a systematic review and meta-analysis.
Liu B, Guo Y, Deng L, Qiao Y, Jian J
Hematology 2020 Dec;25(1):414-423. doi: 10.1080/16078454.2020.1843752. PMID: 33191860
Increased circulating vascular endothelial growth factor in acute myeloid leukemia patients: a systematic review and meta-analysis.
Song M, Wang H, Ye Q
Syst Rev 2020 May 6;9(1):103. doi: 10.1186/s13643-020-01368-9. PMID: 32375879Free PMC Article
Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis.
Khalade A, Jaakkola MS, Pukkala E, Jaakkola JJ
Environ Health 2010 Jun 28;9:31. doi: 10.1186/1476-069X-9-31. PMID: 20584305Free PMC Article
A systematic review of myeloid leukemias and occupational pesticide exposure.
Van Maele-Fabry G, Duhayon S, Lison D
Cancer Causes Control 2007 Jun;18(5):457-78. Epub 2007 Apr 18 doi: 10.1007/s10552-007-0122-2. PMID: 17443416

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