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Abnormal proportion of exhausted T cells

MedGen UID:
1759343
•Concept ID:
C5421710
•
Finding
HPO: HP:0041080

Definition

A deviation from the normal proportion of exhausted T cell relative to T cell in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal proportion of exhausted T cells

Recent clinical studies

Etiology

Accelerated Maturation, Exhaustion, and Senescence of T cells in 22q11.2 Deletion Syndrome.
Smetanova J, Milota T, Rataj M, Bloomfield M, Sediva A, Klocperk A
J Clin Immunol 2022 Feb;42(2):274-285. Epub 2021 Oct 29 doi: 10.1007/s10875-021-01154-9. PMID: 34716533
T-cell abnormalities in common variable immunodeficiency: the hidden defect.
Wong GK, Huissoon AP
J Clin Pathol 2016 Aug;69(8):672-6. Epub 2016 May 6 doi: 10.1136/jclinpath-2015-203351. PMID: 27153873Free PMC Article

Diagnosis

Patients with idiopathic recurrent miscarriage show higher levels of DR+ activated T-cells that are less responsive to mitogens.
Kuon RJ, Schaumann J, Goeggl T, Strowitzki T, Sadeghi M, Opelz G, Daniel V, Toth B
J Reprod Immunol 2015 Nov;112:82-7. Epub 2015 Sep 20 doi: 10.1016/j.jri.2015.08.006. PMID: 26398781

Therapy

Patients with idiopathic recurrent miscarriage show higher levels of DR+ activated T-cells that are less responsive to mitogens.
Kuon RJ, Schaumann J, Goeggl T, Strowitzki T, Sadeghi M, Opelz G, Daniel V, Toth B
J Reprod Immunol 2015 Nov;112:82-7. Epub 2015 Sep 20 doi: 10.1016/j.jri.2015.08.006. PMID: 26398781

Prognosis

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study.
Chen WJ, Cao H, Cao JW, Zuo L, Qu FJ, Xu D, Zhang H, Gong HY, Chen JX, Ye JQ, Gan SS, Zhou W, Zhu DW, Pan XW, Cui XG
Cell Death Dis 2022 Jan 11;13(1):50. doi: 10.1038/s41419-022-04501-9. PMID: 35017463Free PMC Article
T-cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment.
Cai MC, Zhao X, Cao M, Ma P, Chen M, Wu J, Jia C, He C, Fu Y, Tan L, Xue X, Yu Z, Zhuang G
J Pathol 2020 Jun;251(2):147-159. Epub 2020 May 19 doi: 10.1002/path.5435. PMID: 32222046

Clinical prediction guides

PD-1 blockade counteracts post-COVID-19 immune abnormalities and stimulates the anti-SARS-CoV-2 immune response.
Loretelli C, Abdelsalam A, D'Addio F, Ben Nasr M, Assi E, Usuelli V, Maestroni A, Seelam AJ, Ippolito E, Di Maggio S, Loreggian L, Radovanovic D, Vanetti C, Yang J, El Essawy B, Rossi A, Pastore I, Montefusco L, Lunati ME, Bolla AM, Biasin M, Antinori S, Santus P, Riva A, Zuccotti GV, Galli M, Rusconi S, Fiorina P
JCI Insight 2021 Dec 22;6(24) doi: 10.1172/jci.insight.146701. PMID: 34784300Free PMC Article
T-cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment.
Cai MC, Zhao X, Cao M, Ma P, Chen M, Wu J, Jia C, He C, Fu Y, Tan L, Xue X, Yu Z, Zhuang G
J Pathol 2020 Jun;251(2):147-159. Epub 2020 May 19 doi: 10.1002/path.5435. PMID: 32222046

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