U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Conjunctival Junctional Nevus

MedGen UID:
1761774
•Concept ID:
C5420767
•
Neoplastic Process

Definition

A junctional nevus that arises from the conjunctiva. It occurs almost exclusively in the juxtalimbal bulbar conjunctiva. It is characterized by an intraepithelial proliferation of type A nevus cells and/ or type B nevus cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Junctional Nevus

Recent clinical studies

Etiology

Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Survey of 138 Conjunctival Tumors in the Dominican Republic.
Pellerano F, Gil G, Rosario A, Mañon N, Vargas T, Vizcaíno G
Ophthalmic Epidemiol 2020 Aug;27(4):278-282. Epub 2020 Feb 17 doi: 10.1080/09286586.2020.1730912. PMID: 32066308
Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review.
Costea CF, Turliuc MD, Dimitriu G, Bogdănici CM, MoŢoc A, Chihaia MA, Dancă C, Cucu A, Cărăuleanu A, Dumitrescu N, Indrei L, Turliuc Ş
Rom J Morphol Embryol 2017;58(3):739-747. PMID: 29250649
Conjunctival nevi: Clinical and histopathologic features in a Saudi population.
Alkatan HM, Al-Arfaj KM, Maktabi A
Ann Saudi Med 2010 Jul-Aug;30(4):306-12. doi: 10.4103/0256-4947.65265. PMID: 20622349Free PMC Article
Immunohistochemical studies of conjunctival nevi and melanomas.
Jakobiec FA, Bhat P, Colby KA
Arch Ophthalmol 2010 Feb;128(2):174-83. doi: 10.1001/archophthalmol.2009.394. PMID: 20142539

Diagnosis

Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Survey of 138 Conjunctival Tumors in the Dominican Republic.
Pellerano F, Gil G, Rosario A, Mañon N, Vargas T, Vizcaíno G
Ophthalmic Epidemiol 2020 Aug;27(4):278-282. Epub 2020 Feb 17 doi: 10.1080/09286586.2020.1730912. PMID: 32066308
Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review.
Costea CF, Turliuc MD, Dimitriu G, Bogdănici CM, MoŢoc A, Chihaia MA, Dancă C, Cucu A, Cărăuleanu A, Dumitrescu N, Indrei L, Turliuc Ş
Rom J Morphol Embryol 2017;58(3):739-747. PMID: 29250649
Pigmented conjunctival and scleral lesions.
Liesegang TJ
Mayo Clin Proc 1994 Feb;69(2):151-61. doi: 10.1016/s0025-6196(12)61042-8. PMID: 8309267
Benign conjunctival melanocytic lesions. Clinicopathologic features.
Folberg R, Jakobiec FA, Bernardino VB, Iwamoto T
Ophthalmology 1989 Apr;96(4):436-61. doi: 10.1016/s0161-6420(89)32878-8. PMID: 2657539

Therapy

Clinicopathological characteristics and surgical outcomes of divided nevus of the eyelids: a decade's experience on 73 cases.
Jia R, Zhu H, Lin M, Li Z, Sun Y, Luo M, Fan X
Ann Plast Surg 2012 Feb;68(2):166-70. doi: 10.1097/SAP.0b013e3182119155. PMID: 21629103

Prognosis

Survey of 138 Conjunctival Tumors in the Dominican Republic.
Pellerano F, Gil G, Rosario A, Mañon N, Vargas T, Vizcaíno G
Ophthalmic Epidemiol 2020 Aug;27(4):278-282. Epub 2020 Feb 17 doi: 10.1080/09286586.2020.1730912. PMID: 32066308
Incidence of melanocytic lesions of the conjunctiva in a review of 10 675 ophthalmic specimens.
Novais GA, Fernandes BF, Belfort RN, Castiglione E, Cheema DP, Burnier MN Jr
Int J Surg Pathol 2010 Feb;18(1):60-3. Epub 2008 Jul 8 doi: 10.1177/1066896908319775. PMID: 18611943
Multifocal blue nevus of the conjunctiva.
Berman EL, Shields CL, Sagoo MS, Eagle RC Jr, Shields JA
Surv Ophthalmol 2008 Jan-Feb;53(1):41-9. doi: 10.1016/j.survophthal.2007.10.009. PMID: 18191656
Conjunctival nevi: clinical features and natural course in 410 consecutive patients.
Shields CL, Fasiuddin AF, Mashayekhi A, Shields JA
Arch Ophthalmol 2004 Feb;122(2):167-75. doi: 10.1001/archopht.122.2.167. PMID: 14769591
Pigmented conjunctival and scleral lesions.
Liesegang TJ
Mayo Clin Proc 1994 Feb;69(2):151-61. doi: 10.1016/s0025-6196(12)61042-8. PMID: 8309267

Clinical prediction guides

PRAME Expression in Junctional Melanocytic Proliferations of the Conjunctiva: A Potential Biomarker for Primary Acquired Melanosis/Conjunctival Melanocytic Intraepithelial Lesions.
Huang YY, Hrycaj SM, Chan MP, Stagner AM, Patel RM, Bresler SC
Am J Dermatopathol 2022 Oct 1;44(10):734-740. Epub 2022 Apr 11 doi: 10.1097/DAD.0000000000002201. PMID: 35475786
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Caruncular late-onset junctional nevus: apropos of an anatomo-clinical observation.
Boruga O, Bălăşoiu AT, Giuri S, Munteanu M, Stanca HT, Iovănescu G, Preda MA
Rom J Morphol Embryol 2017;58(4):1461-1464. PMID: 29556641
Fluorescence in situ hybridisation (FISH) in histologically challenging conjunctival melanocytic lesions.
Mudhar HS, Smith K, Talley P, Whitworth A, Atkey N, Rennie IG
Br J Ophthalmol 2013 Jan;97(1):40-6. Epub 2012 Nov 8 doi: 10.1136/bjophthalmol-2012-302261. PMID: 23137666
Conjunctival nevi: clinical features and natural course in 410 consecutive patients.
Shields CL, Fasiuddin AF, Mashayekhi A, Shields JA
Arch Ophthalmol 2004 Feb;122(2):167-75. doi: 10.1001/archopht.122.2.167. PMID: 14769591

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...