U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of the musculoskeletal system

MedGen UID:
1763488
Concept ID:
C3825027
Anatomical Abnormality
HPO: HP:0033127

Definition

An anomaly of the musculoskeletal system, which consists of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue. The musculoskeletal system supports the weight of the body, maintains body position and produces movements of the body or of parts of the body. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the musculoskeletal system

Professional guidelines

PubMed

Gartenberg A, Nessim A, Cho W
Eur Spine J 2021 Oct;30(10):2936-2943. Epub 2021 Jul 16 doi: 10.1007/s00586-021-06927-9. PMID: 34272605
Haffner D, Emma F, Eastwood DM, Duplan MB, Bacchetta J, Schnabel D, Wicart P, Bockenhauer D, Santos F, Levtchenko E, Harvengt P, Kirchhoff M, Di Rocco F, Chaussain C, Brandi ML, Savendahl L, Briot K, Kamenicky P, Rejnmark L, Linglart A
Nat Rev Nephrol 2019 Jul;15(7):435-455. doi: 10.1038/s41581-019-0152-5. PMID: 31068690Free PMC Article
Gauer RL, Semidey MJ
Am Fam Physician 2015 Mar 15;91(6):378-86. PMID: 25822556

Recent clinical studies

Etiology

White C, Milla SS, Maloney JA, Neuberger I
Clin Perinatol 2022 Sep;49(3):623-640. doi: 10.1016/j.clp.2022.05.003. PMID: 36113926
Guero S, Holder-Espinasse M
J Hand Surg Eur Vol 2019 Jan;44(1):80-87. Epub 2018 Oct 31 doi: 10.1177/1753193418807375. PMID: 30380990
Khan Durrani MY, Sohail AH, Khan I, Hashmi P
J Ayub Med Coll Abbottabad 2018 Jan-Mar;30(1):135-137. PMID: 29504352
Baek GH, Kim J
J Hand Surg Asian Pac Vol 2016 Oct;21(3):283-91. doi: 10.1142/S2424835516400087. PMID: 27595943
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Diagnosis

White C, Milla SS, Maloney JA, Neuberger I
Clin Perinatol 2022 Sep;49(3):623-640. doi: 10.1016/j.clp.2022.05.003. PMID: 36113926
Chu A, Chan J, Baxi O
Pediatr Clin North Am 2020 Feb;67(1):85-99. doi: 10.1016/j.pcl.2019.09.011. PMID: 31779839
Bistaraki A, Zarokosta M, Sapsakos TM, Skarpas G, Nousios G, Apostolopoulos AP, Angelis S, Filippou DK
J Long Term Eff Med Implants 2019;29(3):239-246. doi: 10.1615/JLongTermEffMedImplants.2020034017. PMID: 32478997
Khan Durrani MY, Sohail AH, Khan I, Hashmi P
J Ayub Med Coll Abbottabad 2018 Jan-Mar;30(1):135-137. PMID: 29504352
Hamdy RC, Makhdom AM, Saran N, Birch J
J Am Acad Orthop Surg 2014 Apr;22(4):246-55. doi: 10.5435/JAAOS-22-04-246. PMID: 24668354

Therapy

Soper JR, Bonar SF, O'Sullivan DJ, McCredie J, Willert HG
Skeletal Radiol 2019 Apr;48(4):517-525. Epub 2018 Oct 19 doi: 10.1007/s00256-018-3086-2. PMID: 30341712Free PMC Article
Felding UNA
Dan Med J 2018 Mar;65(3) PMID: 29510812
Gao SY, Wu QJ, Zhang TN, Shen ZQ, Liu CX, Xu X, Ji C, Zhao YH
Br J Clin Pharmacol 2017 Oct;83(10):2134-2147. Epub 2017 Jun 10 doi: 10.1111/bcp.13321. PMID: 28513059Free PMC Article
Mutlu-Albayrak H, Bulut C, Çaksen H
Pediatr Neonatol 2017 Apr;58(2):158-164. Epub 2016 Jun 17 doi: 10.1016/j.pedneo.2016.01.009. PMID: 27422007
McMahon SE, LeRoux JA, Smith TO, Hing CB
Knee Surg Sports Traumatol Arthrosc 2016 Sep;24(9):2798-2805. Epub 2015 Jan 7 doi: 10.1007/s00167-014-3498-z. PMID: 25564195

Prognosis

Markovic I, Bosnjakovic P, Milenkovic Z
Curr Pediatr Rev 2020;16(3):200-205. doi: 10.2174/1573396315666191018161535. PMID: 31656152Free PMC Article
Rampal V, Giuliano F
Orthop Traumatol Surg Res 2020 Feb;106(1S):S115-S123. Epub 2019 Oct 21 doi: 10.1016/j.otsr.2019.03.021. PMID: 31648997
Chambers HG, Chambers RC
J Pediatr Orthop 2019 Jul;39(Issue 6, Supplement 1 Suppl 1):S53-S55. doi: 10.1097/BPO.0000000000001386. PMID: 31169650
Litrenta J, Young M, Birch JG, Oetgen ME
J Am Acad Orthop Surg 2019 Mar 15;27(6):e268-e279. doi: 10.5435/JAAOS-D-16-00838. PMID: 30418269
Gao SY, Wu QJ, Zhang TN, Shen ZQ, Liu CX, Xu X, Ji C, Zhao YH
Br J Clin Pharmacol 2017 Oct;83(10):2134-2147. Epub 2017 Jun 10 doi: 10.1111/bcp.13321. PMID: 28513059Free PMC Article

Clinical prediction guides

Litrenta J, Young M, Birch JG, Oetgen ME
J Am Acad Orthop Surg 2019 Mar 15;27(6):e268-e279. doi: 10.5435/JAAOS-D-16-00838. PMID: 30418269
Verano JW
Int J Paleopathol 2017 Dec;19:111-118. Epub 2017 Mar 28 doi: 10.1016/j.ijpp.2017.03.004. PMID: 29198392
Murphy JS, Mubarak SJ
Foot Ankle Clin 2015 Dec;20(4):681-91. Epub 2015 Oct 23 doi: 10.1016/j.fcl.2015.07.009. PMID: 26589086
Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, Kothari M, Lu Y, Fye K, Zhao S, Genant HK
Osteoarthritis Cartilage 2004 Mar;12(3):177-90. doi: 10.1016/j.joca.2003.11.003. PMID: 14972335
Arlet V, Odent T, Aebi M
Eur Spine J 2003 Oct;12(5):456-63. Epub 2003 Jun 14 doi: 10.1007/s00586-003-0555-6. PMID: 14618384Free PMC Article

Recent systematic reviews

Hara S, Kitano M, Kudo S
J Back Musculoskelet Rehabil 2023;36(1):21-33. doi: 10.3233/BMR-210374. PMID: 35871320
Rodríguez-Grande EI, Vargas-Pinilla OC, Torres-Narvaez MR, Rodríguez-Malagón N
Sci Rep 2022 Sep 2;12(1):14988. doi: 10.1038/s41598-022-19086-8. PMID: 36056081Free PMC Article
Schmaranzer F, Kheterpal AB, Bredella MA
AJR Am J Roentgenol 2021 Mar;216(3):585-598. Epub 2021 Jan 21 doi: 10.2214/AJR.20.22783. PMID: 33474984Free PMC Article
Elhennawy K, Schwendicke F
J Dent 2016 Dec;55:16-24. Epub 2016 Sep 28 doi: 10.1016/j.jdent.2016.09.012. PMID: 27693779
Goubert D, Oosterwijck JV, Meeus M, Danneels L
Pain Physician 2016 Sep-Oct;19(7):E985-E1000. PMID: 27676689

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...