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Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Involving the Digestive System

MedGen UID:
1763537
Concept ID:
C5419894
Neoplastic Process

Definition

An extranodal low-grade B-cell non-Hodgkin lymphoma arising in mucosal or glandular tissues of the digestive system. It recapitulates the cytoarchitectural features of mucosa-associated lymphoid tissue (MALT). It is composed of small lymphoid cells, often including marginal zone cells. (WHO 2019) [from NCI]

Professional guidelines

PubMed

Della Biancia C, Hunt M, Furhang E, Wu E, Yahalom J
Int J Radiat Oncol Biol Phys 2005 Jul 1;62(3):745-51. doi: 10.1016/j.ijrobp.2004.10.025. PMID: 15936555
Nakamura T, Inagaki H, Seto M, Nakamura S
J Gastroenterol 2003;38(10):921-9. doi: 10.1007/s00535-003-1234-4. PMID: 14614598
Du MQ, Isaccson PG
Lancet Oncol 2002 Feb;3(2):97-104. doi: 10.1016/s1470-2045(02)00651-4. PMID: 11902529

Recent clinical studies

Etiology

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
Nezos A, Makri P, Gandolfo S, De Vita S, Voulgarelis M, Crow MK, Mavragani CP
Cytokine 2020 Aug;132:154781. Epub 2019 Jul 18 doi: 10.1016/j.cyto.2019.154781. PMID: 31326279
Retamozo S, Brito-Zerón P, Ramos-Casals M
Lupus 2019 Jul;28(8):923-936. Epub 2019 Jun 19 doi: 10.1177/0961203319857132. PMID: 31215845
Pereira MI, Medeiros JA
World J Gastroenterol 2014 Jan 21;20(3):684-98. doi: 10.3748/wjg.v20.i3.684. PMID: 24574742Free PMC Article
Isomoto H, Matsushima K, Hayashi T, Imaizumi Y, Shiota J, Ishii H, Minami H, Ohnita K, Takeshima F, Shikuwa S, Miyazaki Y, Nakao K
BMC Gastroenterol 2013 Dec 26;13:174. doi: 10.1186/1471-230X-13-174. PMID: 24369830Free PMC Article

Diagnosis

Kaur R, Shetty D, Bagal BP, Gujral S, Sengar M, Laskar S, Nayak L, Shet T
Head Neck Pathol 2022 Dec;16(4):1242-1250. Epub 2022 Jun 8 doi: 10.1007/s12105-022-01461-6. PMID: 35674932Free PMC Article
Retamozo S, Brito-Zerón P, Ramos-Casals M
Lupus 2019 Jul;28(8):923-936. Epub 2019 Jun 19 doi: 10.1177/0961203319857132. PMID: 31215845
Abdelwahed Hussein MR
Expert Rev Hematol 2018 Sep;11(9):737-748. Epub 2018 Aug 21 doi: 10.1080/17474086.2018.1506326. PMID: 30058399
Skinnider BF
Arch Pathol Lab Med 2018 Jan;142(1):44-52. Epub 2017 Aug 22 doi: 10.5858/arpa.2016-0610-RA. PMID: 28829152
Park JB, Koo JS
World J Gastroenterol 2014 Mar 21;20(11):2751-9. doi: 10.3748/wjg.v20.i11.2751. PMID: 24659867Free PMC Article

Therapy

Pinnix CC, Gunther JR, Milgrom SA, Cruz Chamorro RJ, Medeiros LJ, Khoury JD, Amini B, Neelapu S, Lee HJ, Westin J, Fowler N, Nastoupil L, Dabaja B
Int J Radiat Oncol Biol Phys 2019 Jun 1;104(2):447-455. Epub 2019 Feb 12 doi: 10.1016/j.ijrobp.2019.02.002. PMID: 30769175Free PMC Article
Yang X, Min X, He W
Medicine (Baltimore) 2018 May;97(21):e10845. doi: 10.1097/MD.0000000000010845. PMID: 29794780Free PMC Article
Choi SI, Kook MC, Hwang S, Kim YI, Lee JY, Kim CG, Choi IJ, Lee H, Eom HS, Cho SJ
Gut Liver 2018 May 15;12(3):278-287. doi: 10.5009/gnl17217. PMID: 29409307Free PMC Article
Anacak Y, Miller RC, Constantinou N, Mamusa AM, Epelbaum R, Li Y, Calduch AL, Kowalczyk A, Weber DC, Kadish SP, Bese N, Poortmans P, Kamer S, Ozsahin M
Int J Radiat Oncol Biol Phys 2012 Jan 1;82(1):315-20. Epub 2010 Nov 13 doi: 10.1016/j.ijrobp.2010.09.046. PMID: 21075560
Santacroce L, Cagiano R, Del Prete R, Bottalico L, Sabatini R, Carlaio RG, Prejbeanu R, Vermesan H, Dragulescu SI, Vermesan D, Motoc A, Losacco T
Clin Ter 2008 Nov-Dec;159(6):457-62. PMID: 19169609

Prognosis

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309
De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413
Abdelwahed Hussein MR
Expert Rev Hematol 2018 Sep;11(9):737-748. Epub 2018 Aug 21 doi: 10.1080/17474086.2018.1506326. PMID: 30058399
Park JB, Koo JS
World J Gastroenterol 2014 Mar 21;20(11):2751-9. doi: 10.3748/wjg.v20.i11.2751. PMID: 24659867Free PMC Article
Pereira MI, Medeiros JA
World J Gastroenterol 2014 Jan 21;20(3):684-98. doi: 10.3748/wjg.v20.i3.684. PMID: 24574742Free PMC Article

Clinical prediction guides

Kaur R, Shetty D, Bagal BP, Gujral S, Sengar M, Laskar S, Nayak L, Shet T
Head Neck Pathol 2022 Dec;16(4):1242-1250. Epub 2022 Jun 8 doi: 10.1007/s12105-022-01461-6. PMID: 35674932Free PMC Article
Chatzis LG, Stergiou IE, Goules AV, Pezoulas V, Tsourouflis G, Fotiadis D, Tzioufas AG, Voulgarelis M
Rheumatology (Oxford) 2022 Aug 30;61(9):3576-3585. doi: 10.1093/rheumatology/keab939. PMID: 34940812
De Vita S, Gandolfo S
Expert Rev Clin Immunol 2019 Sep;15(9):929-938. Epub 2019 Sep 12 doi: 10.1080/1744666X.2019.1649596. PMID: 31347413
Park JB, Koo JS
World J Gastroenterol 2014 Mar 21;20(11):2751-9. doi: 10.3748/wjg.v20.i11.2751. PMID: 24659867Free PMC Article
Isomoto H, Matsushima K, Hayashi T, Imaizumi Y, Shiota J, Ishii H, Minami H, Ohnita K, Takeshima F, Shikuwa S, Miyazaki Y, Nakao K
BMC Gastroenterol 2013 Dec 26;13:174. doi: 10.1186/1471-230X-13-174. PMID: 24369830Free PMC Article

Recent systematic reviews

Al-Khafaf AE, Al-Shahrestani F, Baysal Y, Rahbek Gjerdrum LM, Heegaard S, Pedersen LM, Homøe P
Acta Otolaryngol 2023 Jul-Aug;143(7):610-616. Epub 2023 Aug 12 doi: 10.1080/00016489.2023.2226689. PMID: 37572309

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