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Metastatic Ovarian Clear Cell Adenocarcinoma

MedGen UID:
1763741
•Concept ID:
C5418892
•
Neoplastic Process

Definition

Ovarian clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Ovarian Clear Cell Adenocarcinoma

Professional guidelines

PubMed

Past, Present, and Future of Serum Tumor Markers in Management of Ovarian Cancer: A Guide for the Radiologist.
Rao S, Smith DA, Guler E, Kikano EG, Rajdev MA, Yoest JM, Ramaiya NH, Tirumani SH
Radiographics 2021 Oct;41(6):1839-1856. doi: 10.1148/rg.2021210005. PMID: 34597221
Sustained effect of continuous treatment with bevacizumab following bevacizumab in combination with chemotherapy in a human ovarian clear cell carcinoma xenograft model.
Ishikura N, Yorozu K, Kurasawa M, Yanagisawa M, Sugimoto M, Yamamoto K
Oncol Rep 2019 Sep;42(3):1057-1065. Epub 2019 Jun 26 doi: 10.3892/or.2019.7211. PMID: 31322247Free PMC Article
Primary peritoneal papillary serous adenocarcinoma: clinical and management aspects.
Altaras MM, Aviram R, Cohen I, Cordoba M, Weiss E, Beyth Y
Gynecol Oncol 1991 Mar;40(3):230-6. doi: 10.1016/0090-8258(90)90283-q. PMID: 2013445

Recent clinical studies

Etiology

Pan-cancer whole-genome comparison of primary and metastatic solid tumours.
Martínez-Jiménez F, Movasati A, Brunner SR, Nguyen L, Priestley P, Cuppen E, Van Hoeck A
Nature 2023 Jun;618(7964):333-341. Epub 2023 May 10 doi: 10.1038/s41586-023-06054-z. PMID: 37165194Free PMC Article
Comparison of surgical and oncologic outcomes in patients with clear cell ovarian carcinoma associated with and without endometriosis.
Charatsingha R, Hanamornroongruang S, Benjapibal M, Therasakvichya S, Jaishuen A, Chaopotong P, Srichaikul P, Jareemit N
Arch Gynecol Obstet 2021 Dec;304(6):1569-1576. Epub 2021 May 23 doi: 10.1007/s00404-021-06096-6. PMID: 34023979
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379

Diagnosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).
Offman SL, Longacre TA
Adv Anat Pathol 2012 Sep;19(5):296-312. doi: 10.1097/PAP.0b013e31826663b1. PMID: 22885379
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268

Therapy

Spontaneous arterial thrombosis in a patient with advanced ovarian clear cell cancer: a case report and literature review.
Chen J, Sun H, Wu M, Zhong X, Zhang Y
J Int Med Res 2020 Jun;48(6):300060520926742. doi: 10.1177/0300060520926742. PMID: 32485125Free PMC Article
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma.
Bixel K, Saini U, Kumar Bid H, Fowler J, Riley M, Wanner R, Deepa Priya Dorayappan K, Rajendran S, Konishi I, Matsumura N, Cohn DE, Selvendiran K
Int J Cancer 2017 Nov 1;141(9):1856-1866. Epub 2017 Jul 24 doi: 10.1002/ijc.30847. PMID: 28646535Free PMC Article
The potential of sunitinib as a therapy in ovarian cancer.
Leone Roberti Maggiore U, Valenzano Menada M, Venturini PL, Ferrero S
Expert Opin Investig Drugs 2013 Dec;22(12):1671-86. Epub 2013 Sep 26 doi: 10.1517/13543784.2013.841138. PMID: 24070205
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article

Prognosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Targeting STAT3 by HO3867 induces apoptosis in ovarian clear cell carcinoma.
Bixel K, Saini U, Kumar Bid H, Fowler J, Riley M, Wanner R, Deepa Priya Dorayappan K, Rajendran S, Konishi I, Matsumura N, Cohn DE, Selvendiran K
Int J Cancer 2017 Nov 1;141(9):1856-1866. Epub 2017 Jul 24 doi: 10.1002/ijc.30847. PMID: 28646535Free PMC Article
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article

Clinical prediction guides

Targeting an autocrine IL-6-SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma.
Mehner C, Miller E, Hockla A, Coban M, Weroha SJ, Radisky DC, Radisky ES
Oncogene 2020 Oct;39(42):6606-6618. Epub 2020 Sep 14 doi: 10.1038/s41388-020-01451-4. PMID: 32929152Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Magnetic resonance imaging findings for discriminating clear cell carcinoma and endometrioid carcinoma of the ovary.
Morioka S, Kawaguchi R, Yamada Y, Iwai K, Yoshimoto C, Kobayashi H
J Ovarian Res 2019 Feb 25;12(1):20. doi: 10.1186/s13048-019-0497-1. PMID: 30803452Free PMC Article
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Recent systematic reviews

Clear cell carcinoma of the stomach: a rare tumor variant imparting poor prognosis.
Virgilio E, Rampioni GL, Lombardi M, Balducci G, Pilozzi E, Cavallini M
Acta Chir Belg 2023 Feb;123(1):65-67. Epub 2021 Mar 18 doi: 10.1080/00015458.2021.1900520. PMID: 33710937
Primary ovarian clear cell carcinoma of the abdominal wall--a systematic review of the literature to establish optimal surgical management.
Ohler A, Dudziak M, Sznurkowski JJ
Ginekol Pol 2015 Aug;86(8):574-81. PMID: 26492705

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