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Chromophobe Hepatocellular Carcinoma

MedGen UID:
1764456
•Concept ID:
C5419805
•
Neoplastic Process
Synonym: Chromophobe Hepatocellular Carcinoma with Abrupt Anaplasia

Definition

Hepatocellular carcinoma characterized by the presence of malignant cells with smooth chromophobic cytoplasm, abrupt focal nuclear anaplasia, and scattered microscopic pseudocysts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChromophobe Hepatocellular Carcinoma

Professional guidelines

PubMed

Risk assessment of cancer patients based on HLA-I alleles, neobinders and expression of cytokines.
Dhall A, Patiyal S, Kaur H, Raghava GPS
Comput Biol Med 2023 Dec;167:107594. Epub 2023 Oct 18 doi: 10.1016/j.compbiomed.2023.107594. PMID: 37918263

Recent clinical studies

Etiology

Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features.
Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove DP, Boitnott JK, Meeker AK, Torbenson MS
Mod Pathol 2013 Dec;26(12):1586-93. Epub 2013 May 3 doi: 10.1038/modpathol.2013.68. PMID: 23640129Free PMC Article

Prognosis

Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features.
Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove DP, Boitnott JK, Meeker AK, Torbenson MS
Mod Pathol 2013 Dec;26(12):1586-93. Epub 2013 May 3 doi: 10.1038/modpathol.2013.68. PMID: 23640129Free PMC Article

Clinical prediction guides

Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma.
Kang HJ, Oh JH, Kim YW, Kim W, An J, Sung CO, Kim J, Shim JH, Hwang S, Yu E, Heaphy CM, Hong SM
Liver Int 2021 Oct;41(10):2499-2510. Epub 2021 Jun 15 doi: 10.1111/liv.14975. PMID: 34036718

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