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Refractory Myeloid Neoplasm

MedGen UID:
1764933
Concept ID:
C5419564
Neoplastic Process

Definition

A myeloid neoplasm that does not respond to treatment. [from NCI]

Professional guidelines

PubMed

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Gertz MA
Am J Hematol 2023 Feb;98(2):348-358. Epub 2023 Jan 1 doi: 10.1002/ajh.26796. PMID: 36588395Free PMC Article
Ullmann AJ, Aguado JM, Arikan-Akdagli S, Denning DW, Groll AH, Lagrou K, Lass-Flörl C, Lewis RE, Munoz P, Verweij PE, Warris A, Ader F, Akova M, Arendrup MC, Barnes RA, Beigelman-Aubry C, Blot S, Bouza E, Brüggemann RJM, Buchheidt D, Cadranel J, Castagnola E, Chakrabarti A, Cuenca-Estrella M, Dimopoulos G, Fortun J, Gangneux JP, Garbino J, Heinz WJ, Herbrecht R, Heussel CP, Kibbler CC, Klimko N, Kullberg BJ, Lange C, Lehrnbecher T, Löffler J, Lortholary O, Maertens J, Marchetti O, Meis JF, Pagano L, Ribaud P, Richardson M, Roilides E, Ruhnke M, Sanguinetti M, Sheppard DC, Sinkó J, Skiada A, Vehreschild MJGT, Viscoli C, Cornely OA
Clin Microbiol Infect 2018 May;24 Suppl 1:e1-e38. Epub 2018 Mar 12 doi: 10.1016/j.cmi.2018.01.002. PMID: 29544767

Recent clinical studies

Therapy

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Issa GC, Aldoss I, DiPersio J, Cuglievan B, Stone R, Arellano M, Thirman MJ, Patel MR, Dickens DS, Shenoy S, Shukla N, Kantarjian H, Armstrong SA, Perner F, Perry JA, Rosen G, Bagley RG, Meyers ML, Ordentlich P, Gu Y, Kumar V, Smith S, McGeehan GM, Stein EM
Nature 2023 Mar;615(7954):920-924. Epub 2023 Mar 15 doi: 10.1038/s41586-023-05812-3. PMID: 36922593Free PMC Article
Tanenbaum B, Miett T, Patel SA
Ann Hematol 2023 Jan;102(1):1-11. Epub 2022 Dec 3 doi: 10.1007/s00277-022-05058-5. PMID: 36462062Free PMC Article
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Tabata R, Chi S, Yuda J, Minami Y
Int J Mol Sci 2021 Feb 16;22(4) doi: 10.3390/ijms22041944. PMID: 33669431Free PMC Article

Prognosis

Wang M, Munoz J, Goy A, Locke FL, Jacobson CA, Hill BT, Timmerman JM, Holmes H, Jaglowski S, Flinn IW, McSweeney PA, Miklos DB, Pagel JM, Kersten MJ, Bouabdallah K, Khanal R, Topp MS, Houot R, Beitinjaneh A, Peng W, Fang X, Shen RR, Siddiqi R, Kloos I, Reagan PM
J Clin Oncol 2023 Jan 20;41(3):555-567. Epub 2022 Jun 4 doi: 10.1200/JCO.21.02370. PMID: 35658525Free PMC Article
Perl AE, Larson RA, Podoltsev NA, Strickland S, Wang ES, Atallah E, Schiller GJ, Martinelli G, Neubauer A, Sierra J, Montesinos P, Récher C, Yoon SS, Hosono N, Onozawa M, Chiba S, Kim HJ, Hasabou N, Lu Q, Tiu R, Levis MJ
Blood 2022 Jun 9;139(23):3366-3375. doi: 10.1182/blood.2021011583. PMID: 35081255Free PMC Article
DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Tabata R, Chi S, Yuda J, Minami Y
Int J Mol Sci 2021 Feb 16;22(4) doi: 10.3390/ijms22041944. PMID: 33669431Free PMC Article
Perl AE, Martinelli G, Cortes JE, Neubauer A, Berman E, Paolini S, Montesinos P, Baer MR, Larson RA, Ustun C, Fabbiano F, Erba HP, Di Stasi A, Stuart R, Olin R, Kasner M, Ciceri F, Chou WC, Podoltsev N, Recher C, Yokoyama H, Hosono N, Yoon SS, Lee JH, Pardee T, Fathi AT, Liu C, Hasabou N, Liu X, Bahceci E, Levis MJ
N Engl J Med 2019 Oct 31;381(18):1728-1740. doi: 10.1056/NEJMoa1902688. PMID: 31665578

Clinical prediction guides

Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med 2018 Jun 21;378(25):2386-2398. Epub 2018 Jun 2 doi: 10.1056/NEJMoa1716984. PMID: 29860938
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Ng SW, Mitchell A, Kennedy JA, Chen WC, McLeod J, Ibrahimova N, Arruda A, Popescu A, Gupta V, Schimmer AD, Schuh AC, Yee KW, Bullinger L, Herold T, Görlich D, Büchner T, Hiddemann W, Berdel WE, Wörmann B, Cheok M, Preudhomme C, Dombret H, Metzeler K, Buske C, Löwenberg B, Valk PJ, Zandstra PW, Minden MD, Dick JE, Wang JC
Nature 2016 Dec 15;540(7633):433-437. Epub 2016 Dec 7 doi: 10.1038/nature20598. PMID: 27926740

Recent systematic reviews

Cao S, Tao Q, Wang J, Zhang Q, Dong Y
Medicine (Baltimore) 2023 Nov 3;102(44):e34949. doi: 10.1097/MD.0000000000034949. PMID: 37933074Free PMC Article
Jeha S, Goto H, Baruchel A, Boëlle-Le Corfec E, Geffriaud-Ricouard C, Pieters R, Shin HY
Adv Ther 2023 Dec;40(12):5447-5463. Epub 2023 Oct 11 doi: 10.1007/s12325-023-02696-7. PMID: 37819554Free PMC Article
Shahzad M, Nguyen A, Hussain A, Ammad-Ud-Din M, Faisal MS, Tariq E, Ali F, Butt A, Anwar I, Chaudhary SG, Lutfi F, Ahmed N, Singh AK, Hematti P, McGuirk JP, Mushtaq MU
Front Immunol 2023;14:1152457. Epub 2023 Apr 24 doi: 10.3389/fimmu.2023.1152457. PMID: 37168849Free PMC Article
Du Y, Li C, Yan J
Hematology 2023 Dec;28(1):2198098. doi: 10.1080/16078454.2023.2198098. PMID: 37036307
Stemler J, de Jonge N, Skoetz N, Sinkó J, Brüggemann RJ, Busca A, Ben-Ami R, Ráčil Z, Piechotta V, Lewis R, Cornely OA
Lancet Haematol 2022 May;9(5):e361-e373. doi: 10.1016/S2352-3026(22)00073-4. PMID: 35483397

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