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Non-Neoplastic Respiratory System Disorder

MedGen UID:
1766542
•Concept ID:
C5421222
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Respiratory System Disorder

Professional guidelines

PubMed

The Hematological Differential Diagnosis of Mediastinal Masses.
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors.
Krywanczyk AR, Tan CD, Rodriguez ER
Curr Cardiol Rep 2021 Jul 16;23(9):119. doi: 10.1007/s11886-021-01548-6. PMID: 34269901
Primary lung neoplasms presenting as multiple synchronous lung nodules.
Ghosh S, Mehta AC, Abuquyyas S, Raju S, Farver C
Eur Respir Rev 2020 Sep 30;29(157) Epub 2020 Sep 2 doi: 10.1183/16000617.0142-2019. PMID: 32878970Free PMC Article

Recent clinical studies

Etiology

Characterization of alkaline phosphatase cytochemistry in canine neoplastic and non-neoplastic pulmonary mass aspirates.
O'Day J, Seelig D, Emanuelli M, Heinrich D
Vet Clin Pathol 2023 Dec;52(4):661-669. Epub 2023 Aug 1 doi: 10.1111/vcp.13250. PMID: 37528057
A broad cuproptosis landscape in inflammatory bowel disease.
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Image-Guided Percutaneous Lung Needle Biopsy: How we do it.
Bourgouin PP, Rodriguez KJ, Fintelmann FJ
Tech Vasc Interv Radiol 2021 Sep;24(3):100770. Epub 2021 Sep 27 doi: 10.1016/j.tvir.2021.100770. PMID: 34861971
Non-neoplastic mediastinal cysts.
Zambudio AR, Lanzas JT, Calvo MJ, Fernández PJ, Paricio PP
Eur J Cardiothorac Surg 2002 Nov;22(5):712-6. doi: 10.1016/s1010-7940(02)00484-0. PMID: 12414035

Diagnosis

Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer.
Cheng C, Nguyen TT, Tang M, Wang X, Jiang C, Liu Y, Gorlov I, Gorlova O, Iafrate J, Lanuti M, Christiani DC, Amos CI
J Thorac Oncol 2023 Sep;18(9):1184-1198. Epub 2023 May 4 doi: 10.1016/j.jtho.2023.04.022. PMID: 37146750Free PMC Article
A broad cuproptosis landscape in inflammatory bowel disease.
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
CT findings of non-neoplastic central airways diseases.
Moroni C, Bindi A, Cavigli E, Cozzi D, Luvarà S, Smorchkova O, Zantonelli G, Miele V, Bartolucci M
Jpn J Radiol 2022 Feb;40(2):107-119. Epub 2021 Aug 16 doi: 10.1007/s11604-021-01190-w. PMID: 34398372
Non-Neoplastic Mediastinal Cysts.
Syred K, Weissferdt A
Adv Anat Pathol 2020 Sep;27(5):294-302. doi: 10.1097/PAP.0000000000000261. PMID: 31972565
Idiopathic pulmonary fibrosis.
Meltzer EB, Noble PW
Orphanet J Rare Dis 2008 Mar 26;3:8. doi: 10.1186/1750-1172-3-8. PMID: 18366757Free PMC Article

Therapy

AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Radiation therapy: posterior segment complications.
Seregard S, Pelayes DE, Singh AD
Dev Ophthalmol 2013;52:114-23. Epub 2013 Aug 26 doi: 10.1159/000351088. PMID: 23989132
Evaluation of the carcinogenicity of gallium arsenide.
Bomhard EM, Gelbke HP, Schenk H, Williams GM, Cohen SM
Crit Rev Toxicol 2013 May;43(5):436-66. doi: 10.3109/10408444.2013.792329. PMID: 23706044
Non-neoplastic and neoplastic pleural endpoints following fiber exposure.
Broaddus VC, Everitt JI, Black B, Kane AB
J Toxicol Environ Health B Crit Rev 2011;14(1-4):153-78. doi: 10.1080/10937404.2011.556049. PMID: 21534088Free PMC Article
Exposure to environmental tobacco smoke and adult non-neoplastic respiratory diseases.
Trédaniel J, Boffetta P, Saracci R, Hirsch A
Eur Respir J 1994 Jan;7(1):173-85. doi: 10.1183/09031936.94.07010173. PMID: 8143819

Prognosis

The molecular mechanism of Gorham syndrome: an update.
Xiang J, Zhong W
Front Immunol 2023;14:1165091. Epub 2023 May 5 doi: 10.3389/fimmu.2023.1165091. PMID: 37215116Free PMC Article
Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer.
Cheng C, Nguyen TT, Tang M, Wang X, Jiang C, Liu Y, Gorlov I, Gorlova O, Iafrate J, Lanuti M, Christiani DC, Amos CI
J Thorac Oncol 2023 Sep;18(9):1184-1198. Epub 2023 May 4 doi: 10.1016/j.jtho.2023.04.022. PMID: 37146750Free PMC Article
DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Non-Neoplastic Mediastinal Cysts.
Syred K, Weissferdt A
Adv Anat Pathol 2020 Sep;27(5):294-302. doi: 10.1097/PAP.0000000000000261. PMID: 31972565
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Kim M, Mun H, Sung CO, Cho EJ, Jeon HJ, Chun SM, Jung DJ, Shin TH, Jeong GS, Kim DK, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, Jang SJ
Nat Commun 2019 Sep 5;10(1):3991. doi: 10.1038/s41467-019-11867-6. PMID: 31488816Free PMC Article

Clinical prediction guides

Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer.
Cheng C, Nguyen TT, Tang M, Wang X, Jiang C, Liu Y, Gorlov I, Gorlova O, Iafrate J, Lanuti M, Christiani DC, Amos CI
J Thorac Oncol 2023 Sep;18(9):1184-1198. Epub 2023 May 4 doi: 10.1016/j.jtho.2023.04.022. PMID: 37146750Free PMC Article
A broad cuproptosis landscape in inflammatory bowel disease.
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Clinical practices for non-neoplastic thymic lesions: Results from a multidisciplinary cohort.
Joubert V, Chalabreysse L, Gamondes D, Tronc F, Maury JM, Girard N
Lung Cancer 2022 Apr;166:76-83. Epub 2022 Feb 22 doi: 10.1016/j.lungcan.2022.02.004. PMID: 35227953
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Kim M, Mun H, Sung CO, Cho EJ, Jeon HJ, Chun SM, Jung DJ, Shin TH, Jeong GS, Kim DK, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, Jang SJ
Nat Commun 2019 Sep 5;10(1):3991. doi: 10.1038/s41467-019-11867-6. PMID: 31488816Free PMC Article

Recent systematic reviews

Nasal glial heterotopia: a systematic review of the literature and case report.
Gallego Compte M, Menter T, Guertler N, Negoias S
Acta Otorhinolaryngol Ital 2022 Aug;42(4):317-324. doi: 10.14639/0392-100X-N1977. PMID: 36254649Free PMC Article
Pleural effusion aetiology, presentation, treatment and outcome in haematological diseases: a review.
Fantin A, Castaldo N, Vailati P, Morana G, Orso D, Vetrugno L, Patruno V
Acta Biomed 2021 Nov 3;92(5):e2021268. doi: 10.23750/abm.v92i5.11794. PMID: 34738567Free PMC Article
Clinicopathological significance and a potential drugtarget of RARβ in non-small-cell lung carcinoma: a meta-analysis and a systematic review.
Song X, Shi K, Zhou SJ, Yu DP, Liu Z, Han Y
Drug Des Devel Ther 2016;10:1345-54. Epub 2016 Apr 6 doi: 10.2147/DDDT.S96766. PMID: 27103788Free PMC Article
Asthma in furniture and wood processing workers: a systematic review.
Wiggans RE, Evans G, Fishwick D, Barber CM
Occup Med (Lond) 2016 Apr;66(3):193-201. Epub 2015 Oct 18 doi: 10.1093/occmed/kqv149. PMID: 26482167
Sinonasal organized hematoma: Clinical features of seventeen cases and a systematic review.
Choi SJ, Seo ST, Rha KS, Kim YM
Laryngoscope 2015 Sep;125(9):2027-33. Epub 2015 Feb 13 doi: 10.1002/lary.25200. PMID: 25682739

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