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Non-Neoplastic Respiratory System Disorder

MedGen UID:
1766542
•Concept ID:
C5421222
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, tracheitis, and tracheal agenesis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Respiratory System Disorder

Professional guidelines

PubMed

The Hematological Differential Diagnosis of Mediastinal Masses.
Aljudi A, Weinzierl E, Elkhalifa M, Park S
Clin Lab Med 2021 Sep;41(3):389-404. Epub 2021 Jul 3 doi: 10.1016/j.cll.2021.03.011. PMID: 34304771
A Clinico-Pathologic Approach to the Differential Diagnosis of Pericardial Tumors.
Krywanczyk AR, Tan CD, Rodriguez ER
Curr Cardiol Rep 2021 Jul 16;23(9):119. doi: 10.1007/s11886-021-01548-6. PMID: 34269901
Primary lung neoplasms presenting as multiple synchronous lung nodules.
Ghosh S, Mehta AC, Abuquyyas S, Raju S, Farver C
Eur Respir Rev 2020 Sep 30;29(157) Epub 2020 Sep 2 doi: 10.1183/16000617.0142-2019. PMID: 32878970Free PMC Article

Recent clinical studies

Etiology

A broad cuproptosis landscape in inflammatory bowel disease.
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Image-Guided Percutaneous Lung Needle Biopsy: How we do it.
Bourgouin PP, Rodriguez KJ, Fintelmann FJ
Tech Vasc Interv Radiol 2021 Sep;24(3):100770. Epub 2021 Sep 27 doi: 10.1016/j.tvir.2021.100770. PMID: 34861971
Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers: The eNRGy1 Global Multicenter Registry.
Drilon A, Duruisseaux M, Han JY, Ito M, Falcon C, Yang SR, Murciano-Goroff YR, Chen H, Okada M, Molina MA, Wislez M, Brun P, Dupont C, Branden E, Rossi G, Schrock A, Ali S, Gounant V, Magne F, Blum TG, Schram AM, Monnet I, Shih JY, Sabari J, Pérol M, Zhu VW, Nagasaka M, Doebele R, Camidge DR, Arcila M, Ou SI, Moro-Sibilot D, Rosell R, Muscarella LA, Liu SV, Cadranel J
J Clin Oncol 2021 Sep 1;39(25):2791-2802. Epub 2021 Jun 2 doi: 10.1200/JCO.20.03307. PMID: 34077268Free PMC Article
Exposure to environmental tobacco smoke and adult non-neoplastic respiratory diseases.
Trédaniel J, Boffetta P, Saracci R, Hirsch A
Eur Respir J 1994 Jan;7(1):173-85. doi: 10.1183/09031936.94.07010173. PMID: 8143819

Diagnosis

A broad cuproptosis landscape in inflammatory bowel disease.
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
Non-neoplastic respiratory fluid cytology including cell differential counts for interstitial lung disease.
Rice AJ
Cytopathology 2022 Jan;33(1):44-56. Epub 2021 Oct 20 doi: 10.1111/cyt.13067. PMID: 34628692
CT findings of non-neoplastic central airways diseases.
Moroni C, Bindi A, Cavigli E, Cozzi D, Luvarà S, Smorchkova O, Zantonelli G, Miele V, Bartolucci M
Jpn J Radiol 2022 Feb;40(2):107-119. Epub 2021 Aug 16 doi: 10.1007/s11604-021-01190-w. PMID: 34398372
Image-Guided Percutaneous Lung Needle Biopsy: How we do it.
Bourgouin PP, Rodriguez KJ, Fintelmann FJ
Tech Vasc Interv Radiol 2021 Sep;24(3):100770. Epub 2021 Sep 27 doi: 10.1016/j.tvir.2021.100770. PMID: 34861971
Non-Neoplastic Mediastinal Cysts.
Syred K, Weissferdt A
Adv Anat Pathol 2020 Sep;27(5):294-302. doi: 10.1097/PAP.0000000000000261. PMID: 31972565

Therapy

AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers: The eNRGy1 Global Multicenter Registry.
Drilon A, Duruisseaux M, Han JY, Ito M, Falcon C, Yang SR, Murciano-Goroff YR, Chen H, Okada M, Molina MA, Wislez M, Brun P, Dupont C, Branden E, Rossi G, Schrock A, Ali S, Gounant V, Magne F, Blum TG, Schram AM, Monnet I, Shih JY, Sabari J, Pérol M, Zhu VW, Nagasaka M, Doebele R, Camidge DR, Arcila M, Ou SI, Moro-Sibilot D, Rosell R, Muscarella LA, Liu SV, Cadranel J
J Clin Oncol 2021 Sep 1;39(25):2791-2802. Epub 2021 Jun 2 doi: 10.1200/JCO.20.03307. PMID: 34077268Free PMC Article
Evaluation of the carcinogenicity of gallium arsenide.
Bomhard EM, Gelbke HP, Schenk H, Williams GM, Cohen SM
Crit Rev Toxicol 2013 May;43(5):436-66. doi: 10.3109/10408444.2013.792329. PMID: 23706044
Non-neoplastic and neoplastic pleural endpoints following fiber exposure.
Broaddus VC, Everitt JI, Black B, Kane AB
J Toxicol Environ Health B Crit Rev 2011;14(1-4):153-78. doi: 10.1080/10937404.2011.556049. PMID: 21534088Free PMC Article
Exposure to environmental tobacco smoke and adult non-neoplastic respiratory diseases.
Trédaniel J, Boffetta P, Saracci R, Hirsch A
Eur Respir J 1994 Jan;7(1):173-85. doi: 10.1183/09031936.94.07010173. PMID: 8143819

Prognosis

Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer.
Cheng C, Nguyen TT, Tang M, Wang X, Jiang C, Liu Y, Gorlov I, Gorlova O, Iafrate J, Lanuti M, Christiani DC, Amos CI
J Thorac Oncol 2023 Sep;18(9):1184-1198. Epub 2023 May 4 doi: 10.1016/j.jtho.2023.04.022. PMID: 37146750Free PMC Article
DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers: The eNRGy1 Global Multicenter Registry.
Drilon A, Duruisseaux M, Han JY, Ito M, Falcon C, Yang SR, Murciano-Goroff YR, Chen H, Okada M, Molina MA, Wislez M, Brun P, Dupont C, Branden E, Rossi G, Schrock A, Ali S, Gounant V, Magne F, Blum TG, Schram AM, Monnet I, Shih JY, Sabari J, Pérol M, Zhu VW, Nagasaka M, Doebele R, Camidge DR, Arcila M, Ou SI, Moro-Sibilot D, Rosell R, Muscarella LA, Liu SV, Cadranel J
J Clin Oncol 2021 Sep 1;39(25):2791-2802. Epub 2021 Jun 2 doi: 10.1200/JCO.20.03307. PMID: 34077268Free PMC Article
Non-Neoplastic Mediastinal Cysts.
Syred K, Weissferdt A
Adv Anat Pathol 2020 Sep;27(5):294-302. doi: 10.1097/PAP.0000000000000261. PMID: 31972565
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Kim M, Mun H, Sung CO, Cho EJ, Jeon HJ, Chun SM, Jung DJ, Shin TH, Jeong GS, Kim DK, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, Jang SJ
Nat Commun 2019 Sep 5;10(1):3991. doi: 10.1038/s41467-019-11867-6. PMID: 31488816Free PMC Article

Clinical prediction guides

Immune Infiltration in Tumor and Adjacent Non-Neoplastic Regions Codetermines Patient Clinical Outcomes in Early-Stage Lung Cancer.
Cheng C, Nguyen TT, Tang M, Wang X, Jiang C, Liu Y, Gorlov I, Gorlova O, Iafrate J, Lanuti M, Christiani DC, Amos CI
J Thorac Oncol 2023 Sep;18(9):1184-1198. Epub 2023 May 4 doi: 10.1016/j.jtho.2023.04.022. PMID: 37146750Free PMC Article
A broad cuproptosis landscape in inflammatory bowel disease.
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
AENEAS: A Randomized Phase III Trial of Aumolertinib Versus Gefitinib as First-Line Therapy for Locally Advanced or MetastaticNon-Small-Cell Lung Cancer With EGFR Exon 19 Deletion or L858R Mutations.
Lu S, Dong X, Jian H, Chen J, Chen G, Sun Y, Ji Y, Wang Z, Shi J, Lu J, Chen S, Lv D, Zhang G, Liu C, Li J, Yu X, Lin Z, Yu Z, Wang Z, Cui J, Xu X, Fang J, Feng J, Xu Z, Ma R, Hu J, Yang N, Zhou X, Wu X, Hu C, Zhang Z, Lu Y, Hu Y, Jiang L, Wang Q, Guo R, Zhou J, Li B, Hu C, Tong W, Zhang H, Ma L, Chen Y, Jie Z, Yao Y, Zhang L, Jie W, Li W, Xiong J, Ye X, Duan J, Yang H, Sun M, Sun C, Wei H, Li C, Ali SM, Miller VA, Wu Q
J Clin Oncol 2022 Sep 20;40(27):3162-3171. Epub 2022 May 17 doi: 10.1200/JCO.21.02641. PMID: 35580297Free PMC Article
Image-Guided Percutaneous Lung Needle Biopsy: How we do it.
Bourgouin PP, Rodriguez KJ, Fintelmann FJ
Tech Vasc Interv Radiol 2021 Sep;24(3):100770. Epub 2021 Sep 27 doi: 10.1016/j.tvir.2021.100770. PMID: 34861971
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Kim M, Mun H, Sung CO, Cho EJ, Jeon HJ, Chun SM, Jung DJ, Shin TH, Jeong GS, Kim DK, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, Jang SJ
Nat Commun 2019 Sep 5;10(1):3991. doi: 10.1038/s41467-019-11867-6. PMID: 31488816Free PMC Article

Recent systematic reviews

Nasal glial heterotopia: a systematic review of the literature and case report.
Gallego Compte M, Menter T, Guertler N, Negoias S
Acta Otorhinolaryngol Ital 2022 Aug;42(4):317-324. doi: 10.14639/0392-100X-N1977. PMID: 36254649Free PMC Article
Pleural effusion aetiology, presentation, treatment and outcome in haematological diseases: a review.
Fantin A, Castaldo N, Vailati P, Morana G, Orso D, Vetrugno L, Patruno V
Acta Biomed 2021 Nov 3;92(5):e2021268. doi: 10.23750/abm.v92i5.11794. PMID: 34738567Free PMC Article
Benign multicystic mesothelioma and peritoneal inclusion cysts: are they the same clinical and histopathological entities? A systematic review to find an evidence-based management.
Rapisarda AMC, Cianci A, Caruso S, Vitale SG, Valenti G, Piombino E, Cianci S
Arch Gynecol Obstet 2018 Jun;297(6):1353-1375. Epub 2018 Mar 6 doi: 10.1007/s00404-018-4728-2. PMID: 29511797
Clinicopathological significance and a potential drugtarget of RARβ in non-small-cell lung carcinoma: a meta-analysis and a systematic review.
Song X, Shi K, Zhou SJ, Yu DP, Liu Z, Han Y
Drug Des Devel Ther 2016;10:1345-54. Epub 2016 Apr 6 doi: 10.2147/DDDT.S96766. PMID: 27103788Free PMC Article
Sinonasal organized hematoma: Clinical features of seventeen cases and a systematic review.
Choi SJ, Seo ST, Rha KS, Kim YM
Laryngoscope 2015 Sep;125(9):2027-33. Epub 2015 Feb 13 doi: 10.1002/lary.25200. PMID: 25682739

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