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Anti-citrullinated protein antibody positivity

MedGen UID:
1767562
•Concept ID:
C5421563
•
Laboratory or Test Result
HPO: HP:0033034

Definition

The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-citrullinated protein antibody positivity

Conditions with this feature

Rheumatoid arthritis
MedGen UID:
2078
•Concept ID:
C0003873
•
Disease or Syndrome
Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component.
See: Condition Record
Rheumatoid arthritis

Professional guidelines

PubMed

Elderly-Onset Rheumatoid Arthritis: Characteristics and Treatment Options.
Pavlov-Dolijanovic S, Bogojevic M, Nozica-Radulovic T, Radunovic G, Mujovic N
Medicina (Kaunas) 2023 Oct 23;59(10) doi: 10.3390/medicina59101878. PMID: 37893596Free PMC Article
Measuring ACPA in the general population or primary care: is it useful?
Finckh A, Courvoisier D, Lamacchia C; Recherche clinique en rhumatismes inflammatoires
RMD Open 2020 Feb;6(1) doi: 10.1136/rmdopen-2019-001085. PMID: 32079664Free PMC Article
Use and utility of serologic tests for rheumatoid arthritis in primary care.
Tenstad HB, Nilsson AC, Dellgren CD, Lindegaard HM, Rubin KH, Lillevang ST
Dan Med J 2020 Feb;67(2) PMID: 32053486

Recent systematic reviews

Baseline patient reported outcomes are more consistent predictors of long-term functional disability than laboratory, imaging or joint count data in patients with early inflammatory arthritis: A systematic review.
Gwinnutt JM, Sharp CA, Symmons DPM, Lunt M, Verstappen SMM
Semin Arthritis Rheum 2018 Dec;48(3):384-398. Epub 2018 Mar 15 doi: 10.1016/j.semarthrit.2018.03.004. PMID: 29680162Free PMC Article

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