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Conjunctival Reactive Epithelial Hyperplasia

MedGen UID:
1768392
•Concept ID:
C5420760
•
Disease or Syndrome

Definition

A non-neoplastic proliferation of the conjunctival epithelium in response to irritating stimuli. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Reactive Epithelial Hyperplasia

Professional guidelines

PubMed

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
The differential diagnosis of localised amelanotic limbal lesions: a review of 162 consecutive excisions.
Rudkin AK, Dodd T, Muecke JS
Br J Ophthalmol 2011 Mar;95(3):350-4. Epub 2010 Sep 13 doi: 10.1136/bjo.2009.172189. PMID: 20837790

Recent clinical studies

Etiology

Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
The differential diagnosis of localised amelanotic limbal lesions: a review of 162 consecutive excisions.
Rudkin AK, Dodd T, Muecke JS
Br J Ophthalmol 2011 Mar;95(3):350-4. Epub 2010 Sep 13 doi: 10.1136/bjo.2009.172189. PMID: 20837790

Diagnosis

Anterior segment optical coherence tomography in ocular surface tumours and simulating lesions.
Gündüz AK, Mirzayev I, Okcu Heper A, Kuzu I, Gahramanli Z, Cansiz Ersöz C, Gündüz ÖÖ, Ataoğlu Ö
Eye (Lond) 2023 Apr;37(5):925-937. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02339-1. PMID: 36513855Free PMC Article
A Case of Anti-BP180-type Mucous Membrane Pemphigoid with IgG and IgA Autoantibodies Showing Distinct Reactivities.
Minakawa S, Matsuzaki Y, Hashimoto T, Ishii N, Nishie W, Nakazawa M, Sawamura D
Acta Dermatovenerol Croat 2022 Jul;30(1):54-56. PMID: 36153720
Conjunctival squamous intraepithelial neoplasia and its differential diagnosis.
Reese A, Margo CE
J Clin Pathol 2022 May;75(5):354-358. Epub 2021 Feb 22 doi: 10.1136/jclinpath-2020-207302. PMID: 33619216
The differential diagnosis of localised amelanotic limbal lesions: a review of 162 consecutive excisions.
Rudkin AK, Dodd T, Muecke JS
Br J Ophthalmol 2011 Mar;95(3):350-4. Epub 2010 Sep 13 doi: 10.1136/bjo.2009.172189. PMID: 20837790
The radiological spectrum of orbital pathologies that involve the lacrimal gland and the lacrimal fossa.
Jung WS, Ahn KJ, Park MR, Kim JY, Choi JJ, Kim BS, Hahn ST
Korean J Radiol 2007 Jul-Aug;8(4):336-42. doi: 10.3348/kjr.2007.8.4.336. PMID: 17673845Free PMC Article

Therapy

Protective Effects of Licochalcone A Improve Airway Hyper-Responsiveness and Oxidative Stress in a Mouse Model of Asthma.
Huang WC, Liu CY, Shen SC, Chen LC, Yeh KW, Liu SH, Liou CJ
Cells 2019 Jun 20;8(6) doi: 10.3390/cells8060617. PMID: 31226782Free PMC Article
Morin Attenuates Ovalbumin-Induced Airway Inflammation by Modulating Oxidative Stress-Responsive MAPK Signaling.
Ma Y, Ge A, Zhu W, Liu YN, Ji NF, Zha WJ, Zhang JX, Zeng XN, Huang M
Oxid Med Cell Longev 2016;2016:5843672. Epub 2015 Dec 13 doi: 10.1155/2016/5843672. PMID: 26783416Free PMC Article

Prognosis

Diesel exhaust particles (DEP) induce an early redox imbalance followed by an IL-6 mediated inflammatory response on human conjunctival epithelial cells.
Lasagni Vitar RM, Tau J, Janezic NS, Tesone AI, Hvozda Arana AG, Reides CG, Berra A, Ferreira SM, Llesuy SF
Exp Eye Res 2018 Jun;171:37-47. Epub 2018 Mar 7 doi: 10.1016/j.exer.2018.03.005. PMID: 29524384
Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
Milano J, McKay J, Dagenais C, Foster-Brown L, Pognan F, Gadient R, Jacobs RT, Zacco A, Greenberg B, Ciaccio PJ
Toxicol Sci 2004 Nov;82(1):341-58. Epub 2004 Aug 19 doi: 10.1093/toxsci/kfh254. PMID: 15319485

Clinical prediction guides

A Case of Anti-BP180-type Mucous Membrane Pemphigoid with IgG and IgA Autoantibodies Showing Distinct Reactivities.
Minakawa S, Matsuzaki Y, Hashimoto T, Ishii N, Nishie W, Nakazawa M, Sawamura D
Acta Dermatovenerol Croat 2022 Jul;30(1):54-56. PMID: 36153720
Morin Attenuates Ovalbumin-Induced Airway Inflammation by Modulating Oxidative Stress-Responsive MAPK Signaling.
Ma Y, Ge A, Zhu W, Liu YN, Ji NF, Zha WJ, Zhang JX, Zeng XN, Huang M
Oxid Med Cell Longev 2016;2016:5843672. Epub 2015 Dec 13 doi: 10.1155/2016/5843672. PMID: 26783416Free PMC Article
Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
Milano J, McKay J, Dagenais C, Foster-Brown L, Pognan F, Gadient R, Jacobs RT, Zacco A, Greenberg B, Ciaccio PJ
Toxicol Sci 2004 Nov;82(1):341-58. Epub 2004 Aug 19 doi: 10.1093/toxsci/kfh254. PMID: 15319485
Immunohistochemical localization of epidermal growth factor receptor and epithelial antigen in tumors of the human conjunctiva, eyelid, lacrimal gland, and orbit.
Kodama T, Hayasaka S, Setogawa T
Graefes Arch Clin Exp Ophthalmol 1995 Nov;233(11):672-6. doi: 10.1007/BF00164668. PMID: 8566822
Multifocal static creamy choroidal infiltrates. An early sign of lymphoid neoplasia.
Jakobiec FA, Sacks E, Kronish JW, Weiss T, Smith M
Ophthalmology 1987 Apr;94(4):397-406. doi: 10.1016/s0161-6420(87)33453-0. PMID: 3295641

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