U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Immediately Life-Threatening Disorder

MedGen UID:
1771134
•Concept ID:
C5419139
•
Disease or Syndrome
Synonym: Immediately Life-Threatening Disease or Condition

Definition

A disease finding indicating that there is reasonable likelihood that death will occur within a matter of months or premature death is likely without early treatment. (After 21 CFR 312.300) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmediately Life-Threatening Disorder

Professional guidelines

PubMed

Diagnosis and management of duodenal perforations: a narrative review.
Ansari D, Torén W, Lindberg S, Pyrhönen HS, Andersson R
Scand J Gastroenterol 2019 Aug;54(8):939-944. Epub 2019 Jul 27 doi: 10.1080/00365521.2019.1647456. PMID: 31353983
Diagnosis and Treatment of Hemoptysis.
Cordovilla R, Bollo de Miguel E, Nuñez Ares A, Cosano Povedano FJ, Herráez Ortega I, Jiménez Merchán R
Arch Bronconeumol 2016 Jul;52(7):368-77. Epub 2016 Feb 9 doi: 10.1016/j.arbres.2015.12.002. PMID: 26873518
Clinical practice: the management of hyperammonemia.
Häberle J
Eur J Pediatr 2011 Jan;170(1):21-34. Epub 2010 Dec 17 doi: 10.1007/s00431-010-1369-2. PMID: 21165747

Recent clinical studies

Etiology

Myasthenic crisis.
Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. PMID: 28117397Free PMC Article
Diagnosis and Treatment of Hemoptysis.
Cordovilla R, Bollo de Miguel E, Nuñez Ares A, Cosano Povedano FJ, Herráez Ortega I, Jiménez Merchán R
Arch Bronconeumol 2016 Jul;52(7):368-77. Epub 2016 Feb 9 doi: 10.1016/j.arbres.2015.12.002. PMID: 26873518
Status dystonicus: a practice guide.
Allen NM, Lin JP, Lynch T, King MD
Dev Med Child Neurol 2014 Feb;56(2):105-12. Epub 2013 Dec 4 doi: 10.1111/dmcn.12339. PMID: 24304390

Diagnosis

Managing Massive Hemoptysis.
Davidson K, Shojaee S
Chest 2020 Jan;157(1):77-88. Epub 2019 Jul 30 doi: 10.1016/j.chest.2019.07.012. PMID: 31374211
Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. PMID: 28117397Free PMC Article
Status dystonicus: a practice guide.
Allen NM, Lin JP, Lynch T, King MD
Dev Med Child Neurol 2014 Feb;56(2):105-12. Epub 2013 Dec 4 doi: 10.1111/dmcn.12339. PMID: 24304390
How to approach thrombocytopenia.
Stasi R
Hematology Am Soc Hematol Educ Program 2012;2012:191-7. doi: 10.1182/asheducation-2012.1.191. PMID: 23233580

Therapy

Anaphylaxis.
LoVerde D, Iweala OI, Eginli A, Krishnaswamy G
Chest 2018 Feb;153(2):528-543. Epub 2017 Aug 8 doi: 10.1016/j.chest.2017.07.033. PMID: 28800865Free PMC Article
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. PMID: 28117397Free PMC Article
Diagnosis and Treatment of Hemoptysis.
Cordovilla R, Bollo de Miguel E, Nuñez Ares A, Cosano Povedano FJ, Herráez Ortega I, Jiménez Merchán R
Arch Bronconeumol 2016 Jul;52(7):368-77. Epub 2016 Feb 9 doi: 10.1016/j.arbres.2015.12.002. PMID: 26873518
Status dystonicus: a practice guide.
Allen NM, Lin JP, Lynch T, King MD
Dev Med Child Neurol 2014 Feb;56(2):105-12. Epub 2013 Dec 4 doi: 10.1111/dmcn.12339. PMID: 24304390
How to approach thrombocytopenia.
Stasi R
Hematology Am Soc Hematol Educ Program 2012;2012:191-7. doi: 10.1182/asheducation-2012.1.191. PMID: 23233580

Prognosis

Myasthenic crisis.
Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503
Managing Massive Hemoptysis.
Davidson K, Shojaee S
Chest 2020 Jan;157(1):77-88. Epub 2019 Jul 30 doi: 10.1016/j.chest.2019.07.012. PMID: 31374211
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. PMID: 28117397Free PMC Article
Diagnosis and Treatment of Hemoptysis.
Cordovilla R, Bollo de Miguel E, Nuñez Ares A, Cosano Povedano FJ, Herráez Ortega I, Jiménez Merchán R
Arch Bronconeumol 2016 Jul;52(7):368-77. Epub 2016 Feb 9 doi: 10.1016/j.arbres.2015.12.002. PMID: 26873518
Clinical practice: the management of hyperammonemia.
Häberle J
Eur J Pediatr 2011 Jan;170(1):21-34. Epub 2010 Dec 17 doi: 10.1007/s00431-010-1369-2. PMID: 21165747

Clinical prediction guides

Drug-associated thrombocytopenia.
Bakchoul T, Marini I
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):576-583. doi: 10.1182/asheducation-2018.1.576. PMID: 30504360Free PMC Article
Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure.
Matsue Y, Damman K, Voors AA, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, Matsukawa R, Kato K, Suzuki S, Naruke T, Yoshioka K, Miyoshi T, Baba Y, Yamamoto M, Murai K, Mizutani K, Yoshida K, Kitai T
J Am Coll Cardiol 2017 Jun 27;69(25):3042-3051. doi: 10.1016/j.jacc.2017.04.042. PMID: 28641794
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL
Nat Rev Dis Primers 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. PMID: 28117397Free PMC Article
Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.
Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J
JAMA 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517. PMID: 25203083
Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.
Anon JB, Jacobs MR, Poole MD, Ambrose PG, Benninger MS, Hadley JA, Craig WA; Sinus And Allergy Health Partnership
Otolaryngol Head Neck Surg 2004 Jan;130(1 Suppl):1-45. doi: 10.1016/j.otohns.2003.12.003. PMID: 14726904Free PMC Article

Recent systematic reviews

The Prevalence of Gastrointestinal Bleeding in COVID-19 Patients: A Systematic Review and Meta-Analysis.
Karlafti E, Tsavdaris D, Kotzakioulafi E, Protopapas AA, Kaiafa G, Netta S, Savopoulos C, Michalopoulos A, Paramythiotis D
Medicina (Kaunas) 2023 Aug 21;59(8) doi: 10.3390/medicina59081500. PMID: 37629790Free PMC Article
Systemic inflammatory syndromes as life-threatening side effects of immune checkpoint inhibitors: case report and systematic review of the literature.
Liu LL, Skribek M, Harmenberg U, Gerling M
J Immunother Cancer 2023 Mar;11(3) doi: 10.1136/jitc-2022-005841. PMID: 36878533Free PMC Article
Catheter-directed therapies for the treatment of high risk (massive) and intermediate risk (submassive) acute pulmonary embolism.
Harvey JJ, Huang S, Uberoi R
Cochrane Database Syst Rev 2022 Aug 8;8(8):CD013083. doi: 10.1002/14651858.CD013083.pub2. PMID: 35938605Free PMC Article
Classical psychedelics for the treatment of depression and anxiety: A systematic review.
Muttoni S, Ardissino M, John C
J Affect Disord 2019 Nov 1;258:11-24. Epub 2019 Jul 30 doi: 10.1016/j.jad.2019.07.076. PMID: 31382100
Acute and long-term management of food allergy: systematic review.
de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AE, Halken S, Host A, Poulsen LK, Van Ree R, Vlieg-Boerstra BJ, Agache I, Sheikh A; EAACI Food Allergy and Anaphylaxis Guidelines Group
Allergy 2014 Feb;69(2):159-67. Epub 2013 Nov 12 doi: 10.1111/all.12314. PMID: 24215577

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...