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Pyloric gland adenoma

MedGen UID:
1771507
•Concept ID:
C5421225
•
Neoplastic Process
Synonym: Gastric Pyloric Gland Adenoma
 
Monarch Initiative: MONDO:0006391

Definition

A rare neoplastic polyp that arises from the stomach. It is characterized by the presence of gastric epithelial differentiation and pyloric gland-type tubular structures, which are closely packed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPyloric gland adenoma

Professional guidelines

PubMed

Surveillance for pathology associated with cancer on endoscopy (SPACE): criteria to identify high-risk gastric polyps in familial adenomatous polyposis.
Mankaney GN, Cruise M, Sarvepalli S, Bhatt A, Arora Z, Baggot B, Laguardia L, O'Malley M, Church J, Kalady M, Burke CA
Gastrointest Endosc 2020 Sep;92(3):755-762. Epub 2020 May 4 doi: 10.1016/j.gie.2020.04.065. PMID: 32380015

Recent clinical studies

Etiology

Large duodenal pyloric gland adenoma successfully resected by endoscopic submucosal dissection.
Takayanagi S, Sakai E, Muramoto T, Hashimoto H, Ohata K
Clin J Gastroenterol 2021 Apr;14(2):538-541. Epub 2021 Mar 4 doi: 10.1007/s12328-021-01367-w. PMID: 33661443
An LCM-based genomic analysis of SPEM, Gastric Cancer and Pyloric Gland Adenoma in an Asian cohort.
Srivastava S, Huang KK, Rebbani K, Das K, Fazreen Z, Yeoh KG, Tan P, Teh M
Mod Pathol 2020 Oct;33(10):2075-2086. Epub 2020 Apr 8 doi: 10.1038/s41379-020-0520-5. PMID: 32269290
Next-generation sequencing identifies 2 genomically distinct groups among pyloric gland adenomas.
Setia N, Wanjari P, Yassan L, Niu N, Kadri S, Ritterhouse L, Misdraji J, Brown I, Segal J, Hart J
Hum Pathol 2020 Mar;97:103-111. Epub 2019 Nov 27 doi: 10.1016/j.humpath.2019.11.004. PMID: 31783043
Clinicopathological Features and Magnifying Chromoendoscopic Findings of Non-Ampullary Duodenal Epithelial Tumors.
Toya Y, Endo M, Akasaka R, Urushikubo J, Gonai T, Asakura K, Yanai S, Kawasaki K, Eizuka M, Uesugi N, Nakamura S, Sugai T, Matsumoto T
Digestion 2018;97(3):219-227. Epub 2018 Feb 9 doi: 10.1159/000485505. PMID: 29428955
Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases.
Choi WT, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A, Johncilla M, Pai RK, Gill RM, Fukayama M, Misdraji J, Lauwers GY
Histopathology 2018 May;72(6):1007-1014. Epub 2018 Mar 5 doi: 10.1111/his.13460. PMID: 29278427

Diagnosis

Gastric Pyloric Gland Adenoma in MUTYH-Associated Polyposis.
Liu C, Matsukuma K, Tejaswi S
Clin Gastroenterol Hepatol 2022 Feb;20(2):A25-A26. Epub 2020 Oct 10 doi: 10.1016/j.cgh.2020.10.005. PMID: 33049409
Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review.
Li HL, Wang Y, Ren YB, Yang XS, Wang L, Zhang L, Lin XC
Medicine (Baltimore) 2021 Jun 25;100(25):e26378. doi: 10.1097/MD.0000000000026378. PMID: 34160413Free PMC Article
Some observations on pyloric gland adenoma: an uncommon and long ignored entity!
Vieth M, Montgomery EA
J Clin Pathol 2014 Oct;67(10):883-90. doi: 10.1136/jclinpath-2014-202553. PMID: 25092673
Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T
Gastric Cancer 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8. PMID: 16952035
Pyloric gland adenoma-- how to diagnose?
Vieth M, Vogel C, Kushima R, Borchard F, Stolte M
Cesk Patol 2006 Jan;42(1):4-7. PMID: 16506593

Prognosis

Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review.
Li HL, Wang Y, Ren YB, Yang XS, Wang L, Zhang L, Lin XC
Medicine (Baltimore) 2021 Jun 25;100(25):e26378. doi: 10.1097/MD.0000000000026378. PMID: 34160413Free PMC Article
Next-generation sequencing identifies 2 genomically distinct groups among pyloric gland adenomas.
Setia N, Wanjari P, Yassan L, Niu N, Kadri S, Ritterhouse L, Misdraji J, Brown I, Segal J, Hart J
Hum Pathol 2020 Mar;97:103-111. Epub 2019 Nov 27 doi: 10.1016/j.humpath.2019.11.004. PMID: 31783043
Reduced αGlcNAc glycosylation on gastric gland mucin is a biomarker of malignant potential for gastric cancer, Barrett's adenocarcinoma, and pancreatic cancer.
Yamanoi K, Nakayama J
Histochem Cell Biol 2018 Jun;149(6):569-575. Epub 2018 Apr 16 doi: 10.1007/s00418-018-1667-8. PMID: 29658052
Pyloric gland adenoma in Lynch syndrome.
Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM
Am J Surg Pathol 2014 Jun;38(6):784-92. doi: 10.1097/PAS.0000000000000185. PMID: 24518125Free PMC Article
Pyloric gland adenoma-- how to diagnose?
Vieth M, Vogel C, Kushima R, Borchard F, Stolte M
Cesk Patol 2006 Jan;42(1):4-7. PMID: 16506593

Clinical prediction guides

Decreased expression of TFF2 and decreased αGlcNAc glycosylation are malignant biomarkers of pyloric gland adenoma of the duodenum.
Yamanoi K, Fujii C, Nakayama A, Matsuura N, Takatori Y, Kato M, Yahagi N, Nakayama J
Sci Rep 2023 Dec 8;13(1):21641. doi: 10.1038/s41598-023-49040-1. PMID: 38062108Free PMC Article
An LCM-based genomic analysis of SPEM, Gastric Cancer and Pyloric Gland Adenoma in an Asian cohort.
Srivastava S, Huang KK, Rebbani K, Das K, Fazreen Z, Yeoh KG, Tan P, Teh M
Mod Pathol 2020 Oct;33(10):2075-2086. Epub 2020 Apr 8 doi: 10.1038/s41379-020-0520-5. PMID: 32269290
Some observations on pyloric gland adenoma: an uncommon and long ignored entity!
Vieth M, Montgomery EA
J Clin Pathol 2014 Oct;67(10):883-90. doi: 10.1136/jclinpath-2014-202553. PMID: 25092673
Pyloric gland adenoma in Lynch syndrome.
Lee SE, Kang SY, Cho J, Lee B, Chang DK, Woo H, Kim JW, Park HY, Do IG, Kim YE, Kushima R, Lauwers GY, Park CK, Kim KM
Am J Surg Pathol 2014 Jun;38(6):784-92. doi: 10.1097/PAS.0000000000000185. PMID: 24518125Free PMC Article
Pyloric gland adenoma-- how to diagnose?
Vieth M, Vogel C, Kushima R, Borchard F, Stolte M
Cesk Patol 2006 Jan;42(1):4-7. PMID: 16506593

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