U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uveal cancer

MedGen UID:
1772018
•Concept ID:
C3665670
•
Neoplastic Process
Synonyms: cancer of uvea; Malignant Neoplasm of the Uvea; malignant neoplasm of the uvea; Malignant Neoplasm of Uvea; malignant neoplasm of uvea; Malignant Tumor of the Uvea; malignant tumor of the uvea; Malignant Tumor of Uvea; malignant tumor of uvea; malignant tumour of the uvea; malignant tumour of uvea; Malignant Uvea Neoplasm; malignant uvea neoplasm; Malignant Uvea Tumor; malignant uvea tumor; malignant uvea tumour; Malignant Uveal Neoplasm; malignant uveal neoplasm; Malignant Uveal Tract Neoplasm; Malignant Uveal Tumor; malignant uveal tumor; malignant uveal tumour; uvea cancer; uveal cancer
 
Monarch Initiative: MONDO:0002659

Definition

A primary or metastatic malignant neoplasm that affects the choroid, ciliary body, or iris. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUveal cancer

Professional guidelines

PubMed

Advances in the clinical management of uveal melanoma.
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Uveal melanoma-associated survival in Scotland.
Jamison A, Bhatti LA, Sobti MM, Chadha V, Cauchi P, Kemp EG
Eye (Lond) 2019 Nov;33(11):1699-1706. Epub 2019 Oct 25 doi: 10.1038/s41433-019-0622-9. PMID: 31649344Free PMC Article
Updates in imaging in ocular oncology.
Davila JR, Mruthyunjaya P
F1000Res 2019;8 Epub 2019 Oct 1 doi: 10.12688/f1000research.19979.1. PMID: 31602297Free PMC Article
Novel therapeutic strategies and targets in advanced uveal melanoma.
Chua V, Aplin AE
Curr Opin Oncol 2018 Mar;30(2):134-141. doi: 10.1097/CCO.0000000000000425. PMID: 29206651
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Diagnosis

Posterior segment manifestations of ocular metastasis.
Kongwattananon W, Pothikamjorn T, Somkijrungroj T
Curr Opin Ophthalmol 2023 Nov 1;34(6):522-528. Epub 2023 Aug 9 doi: 10.1097/ICU.0000000000000988. PMID: 37556166
Updates in imaging in ocular oncology.
Davila JR, Mruthyunjaya P
F1000Res 2019;8 Epub 2019 Oct 1 doi: 10.12688/f1000research.19979.1. PMID: 31602297Free PMC Article
Primary iris leiomyoma.
Yeaney GA, Platt S, Singh AD
Surv Ophthalmol 2017 May-Jun;62(3):366-370. Epub 2016 Nov 24 doi: 10.1016/j.survophthal.2016.11.007. PMID: 27890619
Uveal melanoma.
Kashyap S, Meel R, Singh L, Singh M
Semin Diagn Pathol 2016 May;33(3):141-7. Epub 2016 Mar 10 doi: 10.1053/j.semdp.2015.10.005. PMID: 26972224
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Therapy

Three-Year Overall Survival with Tebentafusp in Metastatic Uveal Melanoma.
Hassel JC, Piperno-Neumann S, Rutkowski P, Baurain JF, Schlaak M, Butler MO, Sullivan RJ, Dummer R, Kirkwood JM, Orloff M, Sacco JJ, Ochsenreither S, Joshua AM, Gastaud L, Curti B, Piulats JM, Salama AKS, Shoushtari AN, Demidov L, Milhem M, Chmielowski B, Kim KB, Carvajal RD, Hamid O, Collins L, Ranade K, Holland C, Pfeiffer C, Nathan P
N Engl J Med 2023 Dec 14;389(24):2256-2266. Epub 2023 Oct 21 doi: 10.1056/NEJMoa2304753. PMID: 37870955
Clinical and molecular response to tebentafusp in previously treated patients with metastatic uveal melanoma: a phase 2 trial.
Carvajal RD, Butler MO, Shoushtari AN, Hassel JC, Ikeguchi A, Hernandez-Aya L, Nathan P, Hamid O, Piulats JM, Rioth M, Johnson DB, Luke JJ, Espinosa E, Leyvraz S, Collins L, Goodall HM, Ranade K, Holland C, Abdullah SE, Sacco JJ, Sato T
Nat Med 2022 Nov;28(11):2364-2373. Epub 2022 Oct 13 doi: 10.1038/s41591-022-02015-7. PMID: 36229663Free PMC Article
Tebentafusp for the treatment of HLA-A*02:01-positive adult patients with unresectable or metastatic uveal melanoma.
Chen LN, Carvajal RD
Expert Rev Anticancer Ther 2022 Oct;22(10):1017-1027. Epub 2022 Sep 19 doi: 10.1080/14737140.2022.2124971. PMID: 36102132Free PMC Article
Metastatic uveal melanoma: The final frontier.
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.
Nathan P, Hassel JC, Rutkowski P, Baurain JF, Butler MO, Schlaak M, Sullivan RJ, Ochsenreither S, Dummer R, Kirkwood JM, Joshua AM, Sacco JJ, Shoushtari AN, Orloff M, Piulats JM, Milhem M, Salama AKS, Curti B, Demidov L, Gastaud L, Mauch C, Yushak M, Carvajal RD, Hamid O, Abdullah SE, Holland C, Goodall H, Piperno-Neumann S; IMCgp100-202 Investigators
N Engl J Med 2021 Sep 23;385(13):1196-1206. doi: 10.1056/NEJMoa2103485. PMID: 34551229

Prognosis

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Conjunctival and uveal melanoma: Survival and risk factors following orbital exenteration.
Baum SH, Westekemper H, Bechrakis NE, Mohr C
Eur J Ophthalmol 2022 Jan;32(1):612-619. Epub 2021 Feb 11 doi: 10.1177/1120672121995131. PMID: 33573425
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma.
Kashyap S, Meel R, Singh L, Singh M
Semin Diagn Pathol 2016 May;33(3):141-7. Epub 2016 Mar 10 doi: 10.1053/j.semdp.2015.10.005. PMID: 26972224
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Clinical prediction guides

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Pyroptosis relates to tumor microenvironment remodeling and prognosis: A pan-cancer perspective.
Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A, Chen C, Huang Z, Qiu W, Zhang J, Tian Y, Yuan Y
Front Immunol 2022;13:1062225. Epub 2022 Dec 20 doi: 10.3389/fimmu.2022.1062225. PMID: 36605187Free PMC Article
Roles and mechanisms of BAP1 deubiquitinase in tumor suppression.
Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, Affar EB
Cell Death Differ 2021 Feb;28(2):606-625. Epub 2021 Jan 18 doi: 10.1038/s41418-020-00709-4. PMID: 33462414Free PMC Article
The Interdisciplinary Diagnosis and Treatment of Intraocular Tumors.
Bornfeld N, Biewald E, Bauer S, Temming P, Lohmann D, Zeschnigk M
Dtsch Arztebl Int 2018 Feb 16;115(7):106-111. doi: 10.3238/arztebl.2018.0106. PMID: 29510820Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Recent systematic reviews

Systemic Therapy for Melanoma: ASCO Guideline Update.
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Psychological and behavioral symptoms in patients with melanoma: A systematic review and meta-analysis.
Danielsen JT, Strøm L, Knutzen SM, Schmidt H, Amidi A, Wu LM, Zachariae R
Psychooncology 2023 Aug;32(8):1208-1222. Epub 2023 Jun 27 doi: 10.1002/pon.6184. PMID: 37370196
The Roles of MiRNAs (MicroRNAs) in Melanoma Immunotherapy.
Dong L, Tian X, Zhao Y, Tu H, Wong A, Yang Y
Int J Mol Sci 2022 Nov 25;23(23) doi: 10.3390/ijms232314775. PMID: 36499102Free PMC Article
Treatment and prophylaxis of radiation optic neuropathy: A systematic review and meta-analysis.
Yu CW, Joarder I, Micieli JA
Eur J Ophthalmol 2022 Nov;32(6):3129-3141. Epub 2022 Mar 9 doi: 10.1177/11206721221085409. PMID: 35262423
Systemic Therapy for Melanoma: ASCO Guideline.
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...