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Elevated circulating tenascin-C level

MedGen UID:
1773022
•Concept ID:
C5421622
•
Finding
HPO: HP:0033115

Definition

Abnormally increased concentration of tenascin-C in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating tenascin-C level

Recent clinical studies

Etiology

Assessment of circulating fibrotic proteins (periostin and tenascin -C) In Type 2 diabetes mellitus patients with and without retinopathy.
Indumathi A, Senthilkumar GP, Jayashree K, Ramesh Babu K
Endocrine 2022 Jun;76(3):570-577. Epub 2022 Mar 10 doi: 10.1007/s12020-022-03027-6. PMID: 35274283
Increased Serum Levels of Fetal Tenascin-C Variants in Patients with Pulmonary Hypertension: Novel Biomarkers Reflecting Vascular Remodeling and Right Ventricular Dysfunction?
Rohm I, Grün K, Müller LM, Kretzschmar D, Fritzenwanger M, Yilmaz A, Lauten A, Jung C, Schulze PC, Berndt A, Franz M
Int J Mol Sci 2017 Nov 8;18(11) doi: 10.3390/ijms18112371. PMID: 29117120Free PMC Article
Raised circulating tenascin-C in rheumatoid arthritis.
Page TH, Charles PJ, Piccinini AM, Nicolaidou V, Taylor PC, Midwood KS
Arthritis Res Ther 2012 Nov 29;14(6):R260. doi: 10.1186/ar4105. PMID: 23193984Free PMC Article
Circulating tenascin-C levels in patients with dilated cardiomyopathy in the course of Emery-Dreifuss muscular dystrophy.
Niebroj-Dobosz I, Madej-Pilarczyk A, Marchel M, Sokołowska B, Hausmanowa-Petrusewicz I
Clin Chim Acta 2011 Aug 17;412(17-18):1533-8. Epub 2011 May 5 doi: 10.1016/j.cca.2011.04.033. PMID: 21596026
High circulating levels of large splice variants of tenascin-C is associated with mortality and cardiovascular disease in chronic kidney disease patients.
Liabeuf S, Barreto DV, Kretschmer A, Barreto FC, Renard C, Andrejak M, Choukroun G, Massy Z
Atherosclerosis 2011 Mar;215(1):116-24. Epub 2010 Dec 5 doi: 10.1016/j.atherosclerosis.2010.11.038. PMID: 21183183

Diagnosis

Assessment of circulating fibrotic proteins (periostin and tenascin -C) In Type 2 diabetes mellitus patients with and without retinopathy.
Indumathi A, Senthilkumar GP, Jayashree K, Ramesh Babu K
Endocrine 2022 Jun;76(3):570-577. Epub 2022 Mar 10 doi: 10.1007/s12020-022-03027-6. PMID: 35274283
Raised circulating tenascin-C in rheumatoid arthritis.
Page TH, Charles PJ, Piccinini AM, Nicolaidou V, Taylor PC, Midwood KS
Arthritis Res Ther 2012 Nov 29;14(6):R260. doi: 10.1186/ar4105. PMID: 23193984Free PMC Article
Circulating tenascin-C levels in patients with dilated cardiomyopathy in the course of Emery-Dreifuss muscular dystrophy.
Niebroj-Dobosz I, Madej-Pilarczyk A, Marchel M, Sokołowska B, Hausmanowa-Petrusewicz I
Clin Chim Acta 2011 Aug 17;412(17-18):1533-8. Epub 2011 May 5 doi: 10.1016/j.cca.2011.04.033. PMID: 21596026

Therapy

Raised circulating tenascin-C in rheumatoid arthritis.
Page TH, Charles PJ, Piccinini AM, Nicolaidou V, Taylor PC, Midwood KS
Arthritis Res Ther 2012 Nov 29;14(6):R260. doi: 10.1186/ar4105. PMID: 23193984Free PMC Article
Rapid increase in plasma tenascin-C concentration after isolated limb perfusion with high-dose tumor necrosis factor (TNF), interferon gamma (IFN gamma) and melphalan for regionally advanced tumors.
Schienk S, Liénard D, Gerain J, Baumgartner M, Lejeune FJ, Chiquet-Ehrismann R, Rüegg C
Int J Cancer 1995 Nov 27;63(5):665-72. doi: 10.1002/ijc.2910630511. PMID: 7591283

Prognosis

Increased Serum Levels of Fetal Tenascin-C Variants in Patients with Pulmonary Hypertension: Novel Biomarkers Reflecting Vascular Remodeling and Right Ventricular Dysfunction?
Rohm I, Grün K, Müller LM, Kretzschmar D, Fritzenwanger M, Yilmaz A, Lauten A, Jung C, Schulze PC, Berndt A, Franz M
Int J Mol Sci 2017 Nov 8;18(11) doi: 10.3390/ijms18112371. PMID: 29117120Free PMC Article
Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis.
Ishizaki J, Takemori A, Suemori K, Matsumoto T, Akita Y, Sada KE, Yuzawa Y, Amano K, Takasaki Y, Harigai M, Arimura Y, Makino H, Yasukawa M, Takemori N, Hasegawa H; Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan
Arthritis Res Ther 2017 Sep 29;19(1):218. doi: 10.1186/s13075-017-1429-3. PMID: 28962592Free PMC Article
Raised circulating tenascin-C in rheumatoid arthritis.
Page TH, Charles PJ, Piccinini AM, Nicolaidou V, Taylor PC, Midwood KS
Arthritis Res Ther 2012 Nov 29;14(6):R260. doi: 10.1186/ar4105. PMID: 23193984Free PMC Article
Circulating tenascin-C levels in patients with dilated cardiomyopathy in the course of Emery-Dreifuss muscular dystrophy.
Niebroj-Dobosz I, Madej-Pilarczyk A, Marchel M, Sokołowska B, Hausmanowa-Petrusewicz I
Clin Chim Acta 2011 Aug 17;412(17-18):1533-8. Epub 2011 May 5 doi: 10.1016/j.cca.2011.04.033. PMID: 21596026
High circulating levels of large splice variants of tenascin-C is associated with mortality and cardiovascular disease in chronic kidney disease patients.
Liabeuf S, Barreto DV, Kretschmer A, Barreto FC, Renard C, Andrejak M, Choukroun G, Massy Z
Atherosclerosis 2011 Mar;215(1):116-24. Epub 2010 Dec 5 doi: 10.1016/j.atherosclerosis.2010.11.038. PMID: 21183183

Clinical prediction guides

Assessment of circulating fibrotic proteins (periostin and tenascin -C) In Type 2 diabetes mellitus patients with and without retinopathy.
Indumathi A, Senthilkumar GP, Jayashree K, Ramesh Babu K
Endocrine 2022 Jun;76(3):570-577. Epub 2022 Mar 10 doi: 10.1007/s12020-022-03027-6. PMID: 35274283
Increased Serum Levels of Fetal Tenascin-C Variants in Patients with Pulmonary Hypertension: Novel Biomarkers Reflecting Vascular Remodeling and Right Ventricular Dysfunction?
Rohm I, Grün K, Müller LM, Kretzschmar D, Fritzenwanger M, Yilmaz A, Lauten A, Jung C, Schulze PC, Berndt A, Franz M
Int J Mol Sci 2017 Nov 8;18(11) doi: 10.3390/ijms18112371. PMID: 29117120Free PMC Article
Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis.
Ishizaki J, Takemori A, Suemori K, Matsumoto T, Akita Y, Sada KE, Yuzawa Y, Amano K, Takasaki Y, Harigai M, Arimura Y, Makino H, Yasukawa M, Takemori N, Hasegawa H; Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan
Arthritis Res Ther 2017 Sep 29;19(1):218. doi: 10.1186/s13075-017-1429-3. PMID: 28962592Free PMC Article
Raised circulating tenascin-C in rheumatoid arthritis.
Page TH, Charles PJ, Piccinini AM, Nicolaidou V, Taylor PC, Midwood KS
Arthritis Res Ther 2012 Nov 29;14(6):R260. doi: 10.1186/ar4105. PMID: 23193984Free PMC Article
High circulating levels of large splice variants of tenascin-C is associated with mortality and cardiovascular disease in chronic kidney disease patients.
Liabeuf S, Barreto DV, Kretschmer A, Barreto FC, Renard C, Andrejak M, Choukroun G, Massy Z
Atherosclerosis 2011 Mar;215(1):116-24. Epub 2010 Dec 5 doi: 10.1016/j.atherosclerosis.2010.11.038. PMID: 21183183

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