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Fibrinolysis Shutdown

MedGen UID:
1774231
•Concept ID:
C5420384
•
Disease or Syndrome

Definition

Acute impairment of breaking down fibrin clots leading to venous thromboembolism, stroke, and renal failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrinolysis Shutdown

Professional guidelines

PubMed

COVID-19: coagulation disorders and anticoagulant treatment in patients hospitalised in ICU.
Pluta J, Cieniewicz A, Trzebicki J
Anaesthesiol Intensive Ther 2021;53(2):153-161. doi: 10.5114/ait.2021.105783. PMID: 34006056Free PMC Article
Hemostatic defects in massive transfusion: an update and treatment recommendations.
Napolitano LM
Expert Rev Hematol 2021 Feb;14(2):219-239. Epub 2021 Jan 6 doi: 10.1080/17474086.2021.1858788. PMID: 33267678
ROTEM diagnostic capacity for measuring fibrinolysis in neonatal sepsis.
Lampridou M, Sokou R, Tsantes AG, Theodoraki M, Konstantinidi A, Ioakeimidis G, Bonovas S, Politou M, Valsami S, Iliodromiti Z, Boutsikou T, Iacovidou N, Nikolopoulos G, Tsantes AE
Thromb Res 2020 Aug;192:103-108. Epub 2020 May 20 doi: 10.1016/j.thromres.2020.05.028. PMID: 32464452

Recent clinical studies

Etiology

Hyperfibrinolysis and fibrinolysis shutdown in patients with traumatic brain injury.
Nakae R, Murai Y, Wada T, Fujiki Y, Kanaya T, Takayama Y, Suzuki G, Naoe Y, Yokota H, Yokobori S
Sci Rep 2022 Nov 9;12(1):19107. doi: 10.1038/s41598-022-23912-4. PMID: 36352256Free PMC Article
Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy.
Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS
J Trauma Acute Care Surg 2022 Nov 1;93(5):579-587. Epub 2022 Jun 10 doi: 10.1097/TA.0000000000003723. PMID: 35687811Free PMC Article
Fibrinolysis Shutdown and Thrombosis in a COVID-19 ICU.
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Do not drink and lyse: alcohol intoxication increases fibrinolysis shutdown in injured patients.
Stettler GR, Moore EE, Nunns GR, Moore HB, Huebner BR, Silliman CC, Banerjee A, Sauaia A
Eur J Trauma Emerg Surg 2021 Dec;47(6):1827-1835. Epub 2020 Mar 10 doi: 10.1007/s00068-020-01328-x. PMID: 32157340Free PMC Article
Fibrinolysis Shutdown Is Associated With Thrombotic and Hemorrhagic Complications and Poorer Outcomes After Liver Transplantation.
Nicolau-Raducu R, Beduschi T, Vianna R, Diez C, Sleem M, Singh BP, Vasileiou G, Raveh Y
Liver Transpl 2019 Mar;25(3):380-387. doi: 10.1002/lt.25394. PMID: 30548128

Diagnosis

Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy.
Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS
J Trauma Acute Care Surg 2022 Nov 1;93(5):579-587. Epub 2022 Jun 10 doi: 10.1097/TA.0000000000003723. PMID: 35687811Free PMC Article
Fibrinolysis Shutdown and Thrombosis in a COVID-19 ICU.
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.
Moore HB, Moore EE, Neal MD, Sheppard FR, Kornblith LZ, Draxler DF, Walsh M, Medcalf RL, Cohen MJ, Cotton BA, Thomas SG, Leeper CM, Gaines BA, Sauaia A
Anesth Analg 2019 Sep;129(3):762-773. doi: 10.1213/ANE.0000000000004234. PMID: 31425218Free PMC Article
Fibrinolysis in trauma: a review.
Madurska MJ, Sachse KA, Jansen JO, Rasmussen TE, Morrison JJ
Eur J Trauma Emerg Surg 2018 Feb;44(1):35-44. Epub 2017 Sep 16 doi: 10.1007/s00068-017-0833-3. PMID: 28918481
Tranexamic Acid Update in Trauma.
Ramirez RJ, Spinella PC, Bochicchio GV
Crit Care Clin 2017 Jan;33(1):85-99. doi: 10.1016/j.ccc.2016.08.004. PMID: 27894501

Therapy

Fibrinolysis Shutdown and Thrombosis in a COVID-19 ICU.
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Fibrinolysis Shutdown in Trauma: Historical Review and Clinical Implications.
Moore HB, Moore EE, Neal MD, Sheppard FR, Kornblith LZ, Draxler DF, Walsh M, Medcalf RL, Cohen MJ, Cotton BA, Thomas SG, Leeper CM, Gaines BA, Sauaia A
Anesth Analg 2019 Sep;129(3):762-773. doi: 10.1213/ANE.0000000000004234. PMID: 31425218Free PMC Article
Fibrinolysis in trauma: a review.
Madurska MJ, Sachse KA, Jansen JO, Rasmussen TE, Morrison JJ
Eur J Trauma Emerg Surg 2018 Feb;44(1):35-44. Epub 2017 Sep 16 doi: 10.1007/s00068-017-0833-3. PMID: 28918481
Tranexamic Acid Update in Trauma.
Ramirez RJ, Spinella PC, Bochicchio GV
Crit Care Clin 2017 Jan;33(1):85-99. doi: 10.1016/j.ccc.2016.08.004. PMID: 27894501
Postinjury fibrinolysis shutdown: Rationale for selective tranexamic acid.
Moore EE, Moore HB, Gonzalez E, Chapman MP, Hansen KC, Sauaia A, Silliman CC, Banerjee A
J Trauma Acute Care Surg 2015 Jun;78(6 Suppl 1):S65-9. doi: 10.1097/TA.0000000000000634. PMID: 26002266Free PMC Article

Prognosis

Persistent fibrinolysis shutdown is associated with increased mortality in traumatic pancreatic injury.
Liu B, Yang C, Deng Y, Duan Z, Wang K, Li J, Ding W
Injury 2023 May;54(5):1265-1270. Epub 2023 Feb 7 doi: 10.1016/j.injury.2023.02.013. PMID: 36774266
Hyperfibrinolysis and fibrinolysis shutdown in patients with traumatic brain injury.
Nakae R, Murai Y, Wada T, Fujiki Y, Kanaya T, Takayama Y, Suzuki G, Naoe Y, Yokota H, Yokobori S
Sci Rep 2022 Nov 9;12(1):19107. doi: 10.1038/s41598-022-23912-4. PMID: 36352256Free PMC Article
Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy.
Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS
J Trauma Acute Care Surg 2022 Nov 1;93(5):579-587. Epub 2022 Jun 10 doi: 10.1097/TA.0000000000003723. PMID: 35687811Free PMC Article
Fibrinolysis Shutdown and Thrombosis in a COVID-19 ICU.
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Fibrinolysis Shutdown Is Associated With Thrombotic and Hemorrhagic Complications and Poorer Outcomes After Liver Transplantation.
Nicolau-Raducu R, Beduschi T, Vianna R, Diez C, Sleem M, Singh BP, Vasileiou G, Raveh Y
Liver Transpl 2019 Mar;25(3):380-387. doi: 10.1002/lt.25394. PMID: 30548128

Clinical prediction guides

Fibrinolysis shutdown and elevated D-dimer levels have high prognostic capacity for postoperative thromboembolic complications in patients with bone tumors.
Tsantes AG, Loukopoulou I, Papadopoulos DV, Trikoupis IG, Sokou R, Tsante KA, Mantzios PG, Nikolopoulos GK, Koulouvaris P, Houhoula D, Piovani D, Papagelopoulos PJ, Bonovas S, Tsantes AE
J Thromb Thrombolysis 2023 Apr;55(3):536-544. Epub 2023 Feb 26 doi: 10.1007/s11239-023-02787-w. PMID: 36843157
Persistent fibrinolysis shutdown is associated with increased mortality in traumatic pancreatic injury.
Liu B, Yang C, Deng Y, Duan Z, Wang K, Li J, Ding W
Injury 2023 May;54(5):1265-1270. Epub 2023 Feb 7 doi: 10.1016/j.injury.2023.02.013. PMID: 36774266
Plasma-based assays distinguish hyperfibrinolysis and shutdown subgroups in trauma-induced coagulopathy.
Lawson MA, Holle LA, Dow NE, Hennig G, de Laat B, Moore HB, Moore EE, Cohen MJ, Bouchard BA, Freeman K, Wolberg AS
J Trauma Acute Care Surg 2022 Nov 1;93(5):579-587. Epub 2022 Jun 10 doi: 10.1097/TA.0000000000003723. PMID: 35687811Free PMC Article
Fibrinolysis Shutdown and Thrombosis in a COVID-19 ICU.
Creel-Bulos C, Auld SC, Caridi-Scheible M, Barker NA, Friend S, Gaddh M, Kempton CL, Maier CL, Nahab F, Sniecinski R
Shock 2021 Mar 1;55(3):316-320. doi: 10.1097/SHK.0000000000001635. PMID: 32769822Free PMC Article
Dense and dangerous: The tissue plasminogen activator-resistant fibrinolysis shutdown phenotype is due to abnormal fibrin polymerization.
Dow N, Coleman JR, Moore H, Osborn ZT, Sackheim AM, Hennig G, Butenas S, Nelson MT, Moore EE, Freeman K
J Trauma Acute Care Surg 2020 Feb;88(2):258-265. doi: 10.1097/TA.0000000000002554. PMID: 31999655Free PMC Article

Recent systematic reviews

Hemostasis in Coronavirus Disease 2019-Lesson from Viscoelastic Methods: A Systematic Review.
Słomka A, Kowalewski M, Żekanowska E
Thromb Haemost 2021 Sep;121(9):1181-1192. Epub 2021 Mar 3 doi: 10.1055/a-1346-3178. [Epub ahead of print] PMID: 33401332
Time Course of Hemostatic Disruptions After Traumatic Brain Injury: A Systematic Review of the Literature.
Fletcher-Sandersjöö A, Thelin EP, Maegele M, Svensson M, Bellander BM
Neurocrit Care 2021 Apr;34(2):635-656. doi: 10.1007/s12028-020-01037-8. PMID: 32607969Free PMC Article

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