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Advanced Gastrointestinal Stromal Tumor

MedGen UID:
1774461
•Concept ID:
C5420237
•
Neoplastic Process
Synonym: Advanced GIST

Definition

A gastrointestinal stromal tumor that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

The GIST of Advances in Treatment of Advanced Gastrointestinal Stromal Tumor.
Schaefer IM, DeMatteo RP, Serrano C
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_351231. PMID: 35522913Free PMC Article
Promising novel therapeutic approaches in the management of gastrointestinal stromal tumors.
Szucs Z, Thway K, Fisher C, Bulusu R, Constantinidou A, Benson C, van der Graaf WT, Jones RL
Future Oncol 2017 Jan;13(2):185-194. Epub 2016 Sep 7 doi: 10.2217/fon-2016-0194. PMID: 27600625
Advanced gastrointestinal stromal tumor in Europe: a review of updated treatment recommendations.
Blay JY, Reichardt P
Expert Rev Anticancer Ther 2009 Jun;9(6):831-8. doi: 10.1586/era.09.34. PMID: 19496720

Recent clinical studies

Etiology

Treatment outcomes in older patients with advanced gastrointestinal stromal tumor (GIST).
Rutkowski P, Bylina E, Lugowska I, Teterycz P, Klimczak A, Streb J, Czarnecka AM, Osuch C
J Geriatr Oncol 2018 Sep;9(5):520-525. Epub 2018 Mar 27 doi: 10.1016/j.jgo.2018.03.009. PMID: 29602734
Advanced gastrointestinal stromal tumor patients benefit from palliative surgery after tyrosine kinase inhibitors therapy.
Qiu HB, Zhou ZG, Feng XY, Liu XC, Guo J, Ma MZ, Chen YB, Sun XW, Zhou ZW
Medicine (Baltimore) 2018 Jan;97(2):e9097. doi: 10.1097/MD.0000000000009097. PMID: 29480823Free PMC Article
Key messages from the BFR14 trial of the French Sarcoma Group.
Patrikidou A, Le Cesne A
Future Oncol 2017 Feb;13(3):273-284. Epub 2016 Sep 14 doi: 10.2217/fon-2016-0409. PMID: 27624671
Long-term efficacy of imatinib for treatment of metastatic GIST.
Patel S
Cancer Chemother Pharmacol 2013 Aug;72(2):277-86. Epub 2013 Mar 17 doi: 10.1007/s00280-013-2135-8. PMID: 23503753
Efficacy of surgery and imatinib mesylate in the treatment of advanced gastrointestinal stromal tumor: a systematic review.
Cirocchi R, Farinella E, La Mura F, Cavaliere D, Avenia N, Verdecchia GM, Giustozzi G, Noya G, Sciannameo F
Tumori 2010 May-Jun;96(3):392-9. doi: 10.1177/030089161009600303. PMID: 20845798

Diagnosis

Dutch Gastrointestinal Stromal Tumor (GIST) Registry Data Comparing Sunitinib with Imatinib Dose Escalation in Second-Line Advanced Non-KIT Exon 9 Mutated GIST Patients.
Mohammadi M, Jansen-Werkhoven TM, Ijzerman NS, den Hollander D, Bleckman RF, Oosten AW, Desar IME, Reyners AKL, Steeghs N, Gelderblom H
Target Oncol 2022 Nov;17(6):627-634. Epub 2022 Nov 14 doi: 10.1007/s11523-022-00926-6. PMID: 36374447Free PMC Article
The GIST of Advances in Treatment of Advanced Gastrointestinal Stromal Tumor.
Schaefer IM, DeMatteo RP, Serrano C
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_351231. PMID: 35522913Free PMC Article
Key messages from the BFR14 trial of the French Sarcoma Group.
Patrikidou A, Le Cesne A
Future Oncol 2017 Feb;13(3):273-284. Epub 2016 Sep 14 doi: 10.2217/fon-2016-0409. PMID: 27624671
Response assessment in gastrointestinal stromal tumor.
Desai J
Int J Cancer 2011 Mar 15;128(6):1251-8. Epub 2011 Jan 7 doi: 10.1002/ijc.25729. PMID: 20957633
Advanced gastrointestinal stromal tumor in Europe: a review of updated treatment recommendations.
Blay JY, Reichardt P
Expert Rev Anticancer Ther 2009 Jun;9(6):831-8. doi: 10.1586/era.09.34. PMID: 19496720

Therapy

Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial.
Bauer S, Jones RL, Blay JY, Gelderblom H, George S, Schöffski P, von Mehren M, Zalcberg JR, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Su Y, Meade J, Wang T, Sherman ML, Ruiz-Soto R, Heinrich MC
J Clin Oncol 2022 Dec 1;40(34):3918-3928. Epub 2022 Aug 10 doi: 10.1200/JCO.22.00294. PMID: 35947817Free PMC Article
Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial.
Kurokawa Y, Honma Y, Sawaki A, Naito Y, Iwagami S, Komatsu Y, Takahashi T, Nishida T, Doi T
Ann Oncol 2022 Sep;33(9):959-967. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.518. PMID: 35688358
The GIST of Advances in Treatment of Advanced Gastrointestinal Stromal Tumor.
Schaefer IM, DeMatteo RP, Serrano C
Am Soc Clin Oncol Educ Book 2022 Apr;42:1-15. doi: 10.1200/EDBK_351231. PMID: 35522913Free PMC Article
New drugs in gastrointestinal stromal tumors.
Martin-Broto J, Moura DS
Curr Opin Oncol 2020 Jul;32(4):314-320. doi: 10.1097/CCO.0000000000000642. PMID: 32541319
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H
N Engl J Med 2002 Aug 15;347(7):472-80. doi: 10.1056/NEJMoa020461. PMID: 12181401

Prognosis

Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial.
Kurokawa Y, Honma Y, Sawaki A, Naito Y, Iwagami S, Komatsu Y, Takahashi T, Nishida T, Doi T
Ann Oncol 2022 Sep;33(9):959-967. Epub 2022 Jun 8 doi: 10.1016/j.annonc.2022.05.518. PMID: 35688358
New treatments in advanced gastrointestinal stromal tumor.
Serrano C
Curr Opin Oncol 2021 Jul 1;33(4):323-328. doi: 10.1097/CCO.0000000000000745. PMID: 33867479
Key messages from the BFR14 trial of the French Sarcoma Group.
Patrikidou A, Le Cesne A
Future Oncol 2017 Feb;13(3):273-284. Epub 2016 Sep 14 doi: 10.2217/fon-2016-0409. PMID: 27624671
Long-term efficacy of imatinib for treatment of metastatic GIST.
Patel S
Cancer Chemother Pharmacol 2013 Aug;72(2):277-86. Epub 2013 Mar 17 doi: 10.1007/s00280-013-2135-8. PMID: 23503753
Response assessment in gastrointestinal stromal tumor.
Desai J
Int J Cancer 2011 Mar 15;128(6):1251-8. Epub 2011 Jan 7 doi: 10.1002/ijc.25729. PMID: 20957633

Clinical prediction guides

Dutch Gastrointestinal Stromal Tumor (GIST) Registry Data Comparing Sunitinib with Imatinib Dose Escalation in Second-Line Advanced Non-KIT Exon 9 Mutated GIST Patients.
Mohammadi M, Jansen-Werkhoven TM, Ijzerman NS, den Hollander D, Bleckman RF, Oosten AW, Desar IME, Reyners AKL, Steeghs N, Gelderblom H
Target Oncol 2022 Nov;17(6):627-634. Epub 2022 Nov 14 doi: 10.1007/s11523-022-00926-6. PMID: 36374447Free PMC Article
Ripretinib Versus Sunitinib in Patients With Advanced Gastrointestinal Stromal Tumor After Treatment With Imatinib (INTRIGUE): A Randomized, Open-Label, Phase III Trial.
Bauer S, Jones RL, Blay JY, Gelderblom H, George S, Schöffski P, von Mehren M, Zalcberg JR, Kang YK, Razak AA, Trent J, Attia S, Le Cesne A, Su Y, Meade J, Wang T, Sherman ML, Ruiz-Soto R, Heinrich MC
J Clin Oncol 2022 Dec 1;40(34):3918-3928. Epub 2022 Aug 10 doi: 10.1200/JCO.22.00294. PMID: 35947817Free PMC Article
Sunitinib in pediatric patients with advanced gastrointestinal stromal tumor: results from a phase I/II trial.
Verschuur AC, Bajčiová V, Mascarenhas L, Khosravan R, Lin X, Ingrosso A, Janeway KA
Cancer Chemother Pharmacol 2019 Jul;84(1):41-50. Epub 2019 Apr 20 doi: 10.1007/s00280-019-03814-5. PMID: 31006038Free PMC Article
Response assessment in gastrointestinal stromal tumor.
Desai J
Int J Cancer 2011 Mar 15;128(6):1251-8. Epub 2011 Jan 7 doi: 10.1002/ijc.25729. PMID: 20957633
Efficacy of surgery and imatinib mesylate in the treatment of advanced gastrointestinal stromal tumor: a systematic review.
Cirocchi R, Farinella E, La Mura F, Cavaliere D, Avenia N, Verdecchia GM, Giustozzi G, Noya G, Sciannameo F
Tumori 2010 May-Jun;96(3):392-9. doi: 10.1177/030089161009600303. PMID: 20845798

Recent systematic reviews

Efficacy of surgery and imatinib mesylate in the treatment of advanced gastrointestinal stromal tumor: a systematic review.
Cirocchi R, Farinella E, La Mura F, Cavaliere D, Avenia N, Verdecchia GM, Giustozzi G, Noya G, Sciannameo F
Tumori 2010 May-Jun;96(3):392-9. doi: 10.1177/030089161009600303. PMID: 20845798

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