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Unresectable Primary Peritoneal Carcinoma

MedGen UID:
1775155
•Concept ID:
C5418916
•
Neoplastic Process

Definition

Primary peritoneal carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Primary Peritoneal Carcinoma

Professional guidelines

PubMed

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Peritoneal carcinomatosis of gastrointestinal origin: natural history and treatment options.
Davies JM, O'Neil B
Expert Opin Investig Drugs 2009 Jul;18(7):913-9. doi: 10.1517/13543780902939151. PMID: 19548850

Recent clinical studies

Etiology

Survival impact of occult liver metastasis and peritoneal dissemination compared with radiologically defined distant organ metastasis in pancreatic ductal adenocarcinoma.
Hashimoto D, Sakaguchi T, Satoi S, Yamamoto T, Yamaki S, Ishida M, Matsui Y, Shibata N, Boku S, Katsushima U, Ikeura T, Sekimoto M
Pancreatology 2023 Jan;23(1):73-81. Epub 2022 Dec 1 doi: 10.1016/j.pan.2022.11.012. PMID: 36494309
Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Efficacy of palliative radiotherapy and chemo-radiotherapy for unresectable gastric cancer demonstrating bleeding and obstruction.
Hiramoto S, Kikuchi A, Tetsuso H, Yoshioka A, Kohigashi Y, Maeda I
Int J Clin Oncol 2018 Dec;23(6):1090-1094. Epub 2018 Jul 17 doi: 10.1007/s10147-018-1317-0. PMID: 30019177

Diagnosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Primary rectal carcinoma in patients with stage IV resectable disease at diagnosis.
Pasetto LM, Friso ML, Pucciarelli S, Basso U, Toppan P, Rugge M, Sinigaglia G, Nitti D, Sotti G, Monfardini S
Anticancer Res 2007 Mar-Apr;27(2):1079-85. PMID: 17465247
Pancreatic adenocarcinoma.
Howard TJ
Curr Probl Cancer 1996 Sep-Oct;20(5):281-328. doi: 10.1016/s0147-0272(96)80001-8. PMID: 8902402
Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.
Ajani JA, Mansfield PF, Ota DM
World J Surg 1995 Mar-Apr;19(2):216-20. doi: 10.1007/BF00308629. PMID: 7754626

Therapy

Conversion Surgery After Atezolizumab Plus Bevacizumab for Primary and Peritoneal Metastasis After Hepatocellular Carcinoma Rupture.
Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T, Kubota T, Yanagida E, Murayama T, Miyanari N, Baba H
Anticancer Res 2023 Feb;43(2):943-947. doi: 10.21873/anticanres.16239. PMID: 36697062
Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Efficacy and safety of weekly paclitaxel with or without ramucirumab as second-line therapy for the treatment of advanced gastric or gastroesophageal junction adenocarcinoma (RAINBOW-Asia): a randomised, multicentre, double-blind, phase 3 trial.
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720
Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.
Ajani JA, Mansfield PF, Ota DM
World J Surg 1995 Mar-Apr;19(2):216-20. doi: 10.1007/BF00308629. PMID: 7754626

Prognosis

Is surgical resection justified for pancreatic ductal adenocarcinoma with distant abdominal organ metastasis? A position paper by experts in pancreatic surgery at the Joint Meeting of the International Association of Pancreatology (IAP) & the Japan Pancreas Society (JPS) 2022 in Kyoto.
Hashimoto D, Satoi S, Fujii T, Sho M, He J, Hackert T, Del Chiaro M, Jang JY, Gulla A, Yoon YS, Shan YS, Lou W, Valente R, Furuse J, Oba A, Nagai M, Terai T, Tanaka H, Sakai A, Yamamoto T, Yamaki S, Matsumoto I, Murakami Y, Takaori K, Takeyama Y
Pancreatology 2023 Sep;23(6):682-688. Epub 2023 Jul 20 doi: 10.1016/j.pan.2023.07.005. PMID: 37507301
Conversion Surgery After Atezolizumab Plus Bevacizumab for Primary and Peritoneal Metastasis After Hepatocellular Carcinoma Rupture.
Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T, Kubota T, Yanagida E, Murayama T, Miyanari N, Baba H
Anticancer Res 2023 Feb;43(2):943-947. doi: 10.21873/anticanres.16239. PMID: 36697062
Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.
Li X, Ying H, Cheng Y, Zhao L, Zhao S, Bai C, Zhou J
J BUON 2019 Nov-Dec;24(6):2539-2545. PMID: 31983130
Multidisciplinary management of intrahepatic cholangiocarcinoma: Current approaches.
Guro H, Kim JW, Choi Y, Cho JY, Yoon YS, Han HS
Surg Oncol 2017 Jun;26(2):146-152. Epub 2017 Mar 7 doi: 10.1016/j.suronc.2017.03.001. PMID: 28577720
Potentially resectable gastric carcinoma: current approaches to staging and preoperative therapy.
Ajani JA, Mansfield PF, Ota DM
World J Surg 1995 Mar-Apr;19(2):216-20. doi: 10.1007/BF00308629. PMID: 7754626

Clinical prediction guides

Conversion Surgery After Atezolizumab Plus Bevacizumab for Primary and Peritoneal Metastasis After Hepatocellular Carcinoma Rupture.
Miyata T, Sugi K, Horino T, Ono A, Tagayasu Y, Nomoto D, Inoue M, Mizumoto T, Kubota T, Yanagida E, Murayama T, Miyanari N, Baba H
Anticancer Res 2023 Feb;43(2):943-947. doi: 10.21873/anticanres.16239. PMID: 36697062
Survival impact of occult liver metastasis and peritoneal dissemination compared with radiologically defined distant organ metastasis in pancreatic ductal adenocarcinoma.
Hashimoto D, Sakaguchi T, Satoi S, Yamamoto T, Yamaki S, Ishida M, Matsui Y, Shibata N, Boku S, Katsushima U, Ikeura T, Sekimoto M
Pancreatology 2023 Jan;23(1):73-81. Epub 2022 Dec 1 doi: 10.1016/j.pan.2022.11.012. PMID: 36494309
Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Efficacy of modified FOLFOX6 chemotherapy for patients with unresectable pseudomyxoma peritonei.
Hiraide S, Komine K, Sato Y, Ouchi K, Imai H, Saijo K, Takahashi M, Takahashi S, Shirota H, Takahashi M, Ishioka C
Int J Clin Oncol 2020 Apr;25(4):774-781. Epub 2019 Dec 10 doi: 10.1007/s10147-019-01592-x. PMID: 31823151Free PMC Article
Pancreatic adenocarcinoma.
Howard TJ
Curr Probl Cancer 1996 Sep-Oct;20(5):281-328. doi: 10.1016/s0147-0272(96)80001-8. PMID: 8902402

Recent systematic reviews

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.
Frassini S, Calabretto F, Granieri S, Fugazzola P, Viganò J, Fazzini N, Ansaloni L, Cobianchi L
Eur J Surg Oncol 2022 Sep;48(9):1911-1921. Epub 2022 Jun 2 doi: 10.1016/j.ejso.2022.05.030. PMID: 35688711
Diagnostic accuracy of staging laparoscopy for detecting metastasized or locally advanced perihilar cholangiocarcinoma: a systematic review and meta-analysis.
Coelen RJ, Ruys AT, Besselink MG, Busch OR, van Gulik TM
Surg Endosc 2016 Oct;30(10):4163-73. Epub 2016 Feb 19 doi: 10.1007/s00464-016-4788-y. PMID: 26895909Free PMC Article
Systematic review of prognostic factors related to overall survival in patients with stage IV colorectal cancer and unresectable metastases.
Stillwell AP, Ho YH, Veitch C
World J Surg 2011 Mar;35(3):684-92. doi: 10.1007/s00268-010-0891-8. PMID: 21181473

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