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Elevated circulating osteopontin level

MedGen UID:
1775487
•Concept ID:
C5421626
•
Finding
HPO: HP:0033123

Definition

Abnormally increased level of osteopontin in the blood circulation [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating osteopontin level

Recent clinical studies

Etiology

Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH
Physiol Genomics 2019 Oct 1;51(10):506-515. Epub 2019 Sep 18 doi: 10.1152/physiolgenomics.00033.2019. PMID: 31530226Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy.
Dombai B, Ivancsó I, Bikov A, Oroszi D, Bohács A, Müller V, Rigó J Jr, Vásárhelyi B, Losonczy G, Tamási L
Can Respir J 2017;2017:1602039. Epub 2017 Oct 23 doi: 10.1155/2017/1602039. PMID: 29200898Free PMC Article
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer.
Chang YS, Kim HJ, Chang J, Ahn CM, Kim SK, Kim SK
Lung Cancer 2007 Sep;57(3):373-80. Epub 2007 May 21 doi: 10.1016/j.lungcan.2007.04.005. PMID: 17513004

Diagnosis

Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH
Physiol Genomics 2019 Oct 1;51(10):506-515. Epub 2019 Sep 18 doi: 10.1152/physiolgenomics.00033.2019. PMID: 31530226Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Biomarkers in pulmonary hypertension: what do we know?
Foris V, Kovacs G, Tscherner M, Olschewski A, Olschewski H
Chest 2013 Jul;144(1):274-283. doi: 10.1378/chest.12-1246. PMID: 23880678
Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer.
Chang YS, Kim HJ, Chang J, Ahn CM, Kim SK, Kim SK
Lung Cancer 2007 Sep;57(3):373-80. Epub 2007 May 21 doi: 10.1016/j.lungcan.2007.04.005. PMID: 17513004

Therapy

SPP1 as a risk factor for patients with acute on chronic liver failure undergoing liver transplantation.
Yu Y, Mao X, Wang J, Chen M, Wang F, Kong X, Hang H
Int Immunopharmacol 2023 Jul;120:110355. Epub 2023 May 29 doi: 10.1016/j.intimp.2023.110355. PMID: 37257271
Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH
Physiol Genomics 2019 Oct 1;51(10):506-515. Epub 2019 Sep 18 doi: 10.1152/physiolgenomics.00033.2019. PMID: 31530226Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Does elevated osteopontin level play an important role in the development of scoliosis in bipedal mice?
Xie N, Li M, Wu T, Liu J, Wang B, Tang F
Spine J 2015 Jul 1;15(7):1660-4. Epub 2015 Mar 20 doi: 10.1016/j.spinee.2015.03.014. PMID: 25801389
Pathophysiology of vascular calcification in chronic kidney disease.
Moe SM, Chen NX
Circ Res 2004 Sep 17;95(6):560-7. doi: 10.1161/01.RES.0000141775.67189.98. PMID: 15375022

Prognosis

SPP1 as a risk factor for patients with acute on chronic liver failure undergoing liver transplantation.
Yu Y, Mao X, Wang J, Chen M, Wang F, Kong X, Hang H
Int Immunopharmacol 2023 Jul;120:110355. Epub 2023 May 29 doi: 10.1016/j.intimp.2023.110355. PMID: 37257271
Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH
Physiol Genomics 2019 Oct 1;51(10):506-515. Epub 2019 Sep 18 doi: 10.1152/physiolgenomics.00033.2019. PMID: 31530226Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Biomarkers in pulmonary hypertension: what do we know?
Foris V, Kovacs G, Tscherner M, Olschewski A, Olschewski H
Chest 2013 Jul;144(1):274-283. doi: 10.1378/chest.12-1246. PMID: 23880678

Clinical prediction guides

Circulating interleukin-8 and osteopontin are promising biomarkers of clinical outcomes in advanced melanoma patients treated with targeted therapy.
Levati L, Tabolacci C, Facchiano A, Facchiano F, Alvino E, Antonini Cappellini GC, Scala E, Bonmassar L, Caporali S, Lacal PM, Bresin A, De Galitiis F, Russo G, D'Atri S
J Exp Clin Cancer Res 2024 Aug 15;43(1):226. doi: 10.1186/s13046-024-03151-3. PMID: 39143551Free PMC Article
Osteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms.
Kidess E, Giesecke Y, Eichhorn I, Mohr R, Jann H, Fischer C, Wiedenmann B, Roderburg C, Tacke F, Sigal M
J Cancer Res Clin Oncol 2023 Sep;149(12):10925-10933. Epub 2023 Jun 15 doi: 10.1007/s00432-023-04979-6. PMID: 37318593Free PMC Article
Baseline Plasma Osteopontin Protein Elevation Predicts Adverse Outcomes in Hospitalized COVID-19 Patients.
Tonello S, D'Onghia D, Apostolo D, Matino E, Costanzo M, Casciaro GF, Croce A, Rizzi E, Zecca E, Pedrinelli AR, Vassia V, Ravanini P, Crobu MG, Rizzi M, Landi R, Castello LM, Minisini R, Avanzi GC, Pirisi M, Lilleri D, Bellan M, Colangelo D, Sainaghi PP
Viruses 2023 Feb 25;15(3) doi: 10.3390/v15030630. PMID: 36992339Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Circulating Growth and Angiogenic Factors and Lymph Node Status in Early-stage Breast Cancer - A Pilot Study.
Karlikova M, Topolcan O, Narsanska A, Kucera R, Treskova I, Treska V
Anticancer Res 2016 Aug;36(8):4209-14. PMID: 27466533

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