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Elevated circulating osteopontin level

MedGen UID:
1775487
•Concept ID:
C5421626
•
Finding
HPO: HP:0033123

Definition

Abnormally increased level of osteopontin in the blood circulation [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating osteopontin level

Recent clinical studies

Etiology

Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy.
Dombai B, Ivancsó I, Bikov A, Oroszi D, Bohács A, Müller V, Rigó J Jr, Vásárhelyi B, Losonczy G, Tamási L
Can Respir J 2017;2017:1602039. Epub 2017 Oct 23 doi: 10.1155/2017/1602039. PMID: 29200898Free PMC Article
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Does elevated osteopontin level play an important role in the development of scoliosis in bipedal mice?
Xie N, Li M, Wu T, Liu J, Wang B, Tang F
Spine J 2015 Jul 1;15(7):1660-4. Epub 2015 Mar 20 doi: 10.1016/j.spinee.2015.03.014. PMID: 25801389
Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer.
Chang YS, Kim HJ, Chang J, Ahn CM, Kim SK, Kim SK
Lung Cancer 2007 Sep;57(3):373-80. Epub 2007 May 21 doi: 10.1016/j.lungcan.2007.04.005. PMID: 17513004

Diagnosis

Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Circulating Growth and Angiogenic Factors and Lymph Node Status in Early-stage Breast Cancer - A Pilot Study.
Karlikova M, Topolcan O, Narsanska A, Kucera R, Treskova I, Treska V
Anticancer Res 2016 Aug;36(8):4209-14. PMID: 27466533
Biomarkers in pulmonary hypertension: what do we know?
Foris V, Kovacs G, Tscherner M, Olschewski A, Olschewski H
Chest 2013 Jul;144(1):274-283. doi: 10.1378/chest.12-1246. PMID: 23880678
Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer.
Chang YS, Kim HJ, Chang J, Ahn CM, Kim SK, Kim SK
Lung Cancer 2007 Sep;57(3):373-80. Epub 2007 May 21 doi: 10.1016/j.lungcan.2007.04.005. PMID: 17513004

Therapy

Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH
Physiol Genomics 2019 Oct 1;51(10):506-515. Epub 2019 Sep 18 doi: 10.1152/physiolgenomics.00033.2019. PMID: 31530226Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Does elevated osteopontin level play an important role in the development of scoliosis in bipedal mice?
Xie N, Li M, Wu T, Liu J, Wang B, Tang F
Spine J 2015 Jul 1;15(7):1660-4. Epub 2015 Mar 20 doi: 10.1016/j.spinee.2015.03.014. PMID: 25801389
Osteopontin circulating levels correlate with renal involvement in systemic lupus erythematosus and are lower in ACE inhibitor-treated patients.
Quaglia M, Chiocchetti A, Cena T, Musetti C, Monti S, Clemente N, Dianzani U, Magnani C, Stratta P
Clin Rheumatol 2014 Sep;33(9):1263-71. Epub 2014 May 13 doi: 10.1007/s10067-014-2665-4. PMID: 24820147
Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial.
Lorenzen JM, Neunhöffer H, David S, Kielstein JT, Haller H, Fliser D
Atherosclerosis 2010 Mar;209(1):184-8. Epub 2009 Sep 12 doi: 10.1016/j.atherosclerosis.2009.09.009. PMID: 19801149

Prognosis

Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome.
Kwee LC, Neely ML, Grass E, Gregory SG, Roe MT, Ohman EM, Fox KAA, White HD, Armstrong PW, Bowsman LM, Haas JV, Duffin KL, Chan MY, Shah SH
Physiol Genomics 2019 Oct 1;51(10):506-515. Epub 2019 Sep 18 doi: 10.1152/physiolgenomics.00033.2019. PMID: 31530226Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Elevated levels of circulating osteopontin are associated with a poor survival after resection of cholangiocarcinoma.
Loosen SH, Roderburg C, Kauertz KL, Pombeiro I, Leyh C, Benz F, Vucur M, Longerich T, Koch A, Braunschweig T, Ulmer TF, Heidenhain C, Tacke F, Binnebösel M, Schmeding M, Trautwein C, Neumann UP, Luedde T
J Hepatol 2017 Oct;67(4):749-757. Epub 2017 Jun 29 doi: 10.1016/j.jhep.2017.06.020. PMID: 28668580
Circulating Growth and Angiogenic Factors and Lymph Node Status in Early-stage Breast Cancer - A Pilot Study.
Karlikova M, Topolcan O, Narsanska A, Kucera R, Treskova I, Treska V
Anticancer Res 2016 Aug;36(8):4209-14. PMID: 27466533
Biomarkers in pulmonary hypertension: what do we know?
Foris V, Kovacs G, Tscherner M, Olschewski A, Olschewski H
Chest 2013 Jul;144(1):274-283. doi: 10.1378/chest.12-1246. PMID: 23880678

Clinical prediction guides

Osteopontin is a prognostic circulating biomarker in patients with neuroendocrine neoplasms.
Kidess E, Giesecke Y, Eichhorn I, Mohr R, Jann H, Fischer C, Wiedenmann B, Roderburg C, Tacke F, Sigal M
J Cancer Res Clin Oncol 2023 Sep;149(12):10925-10933. Epub 2023 Jun 15 doi: 10.1007/s00432-023-04979-6. PMID: 37318593Free PMC Article
Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study.
Wang Y, Zhou W, Wu C, Zhang Y, Lin T, Sun Y, Liu W, Tao T
Reprod Biol Endocrinol 2018 Mar 27;16(1):31. doi: 10.1186/s12958-018-0331-4. PMID: 29587769Free PMC Article
Mesothelin and osteopontin as circulating markers of diffuse malignant peritoneal mesothelioma: A preliminary study.
Bruno F, Baratti D, Martinetti A, Morelli D, Sottotetti E, Bonini C, Guaglio M, Kusamura S, Deraco M
Eur J Surg Oncol 2018 Jun;44(6):792-798. Epub 2018 Feb 17 doi: 10.1016/j.ejso.2018.02.010. PMID: 29503128
Circulating Growth and Angiogenic Factors and Lymph Node Status in Early-stage Breast Cancer - A Pilot Study.
Karlikova M, Topolcan O, Narsanska A, Kucera R, Treskova I, Treska V
Anticancer Res 2016 Aug;36(8):4209-14. PMID: 27466533
Increased circulating Th17 cell populations and elevated CSF osteopontin and IL-17 concentrations in patients with Guillain-Barré syndrome.
Han RK, Cheng YF, Zhou SS, Guo H, He RD, Chi LJ, Zhang LM
J Clin Immunol 2014 Jan;34(1):94-103. Epub 2013 Nov 12 doi: 10.1007/s10875-013-9965-3. PMID: 24217817

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