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FUS Gene Rearrangement

MedGen UID:
1775825
Concept ID:
C5420787
Cell or Molecular Dysfunction
Synonyms: FUS Rearrangement; FUS RNA Binding Protein Gene Rearrangement; FUS1 Gene Rearrangement; Fused In Sarcoma Gene Rearrangement; Fusion Gene In Myxoid Liposarcoma Gene Rearrangement; TLS Gene Rearrangement; Translocated In Liposarcoma Gene Rearrangement"

Definition

A molecular abnormality indicating rearrangement of the FUS gene. [from NCI]

Professional guidelines

PubMed

Arbajian E, Puls F, Antonescu CR, Amary F, Sciot R, Debiec-Rychter M, Sumathi VP, Järås M, Magnusson L, Nilsson J, Hofvander J, Mertens F
Clin Cancer Res 2017 Dec 1;23(23):7426-7434. Epub 2017 Sep 22 doi: 10.1158/1078-0432.CCR-17-1856. PMID: 28939748

Recent clinical studies

Etiology

Sun Y, Liu D, Chen X, Zhang J, Yang S
Oral Surg Oral Med Oral Pathol Oral Radiol 2023 May;135(5):e108-e113. Epub 2022 Dec 19 doi: 10.1016/j.oooo.2022.12.003. PMID: 36697296
Agaram NP, Zhang L, Sung YS, Cavalcanti MS, Torrence D, Wexler L, Francis G, Sommerville S, Swanson D, Dickson BC, Suurmeijer AJH, Williamson R, Antonescu CR
Am J Surg Pathol 2019 May;43(5):695-702. doi: 10.1097/PAS.0000000000001227. PMID: 30720533Free PMC Article
Jo VY, Antonescu CR, Zhang L, Dal Cin P, Hornick JL, Fletcher CD
Am J Surg Pathol 2013 May;37(5):710-8. doi: 10.1097/PAS.0b013e3182772bba. PMID: 23588365Free PMC Article
Doyle LA, Wang WL, Dal Cin P, Lopez-Terrada D, Mertens F, Lazar AJ, Fletcher CD, Hornick JL
Am J Surg Pathol 2012 Oct;36(10):1444-51. doi: 10.1097/PAS.0b013e3182562bf8. PMID: 22982887
Matsumura T, Yamaguchi T, Tochigi N, Wada T, Yamashita T, Hasegawa T
J Clin Pathol 2010 Feb;63(2):124-8. doi: 10.1136/jcp.2009.072256. PMID: 20154033

Diagnosis

Vallejo-Benítez A, Rodríguez-Zarco E, Carrasco SP, Pereira-Gallardo S, Brugal Molina J, García-Escudero A, Robles Frías A, Marcilla D, González-Cámpora R
Ann Diagn Pathol 2017 Oct;30:8-11. Epub 2017 May 11 doi: 10.1016/j.anndiagpath.2017.05.002. PMID: 28965630
Chien YC, Károlyi K, Kovács I
Ann Clin Lab Sci 2016 Winter;46(1):90-6. PMID: 26927350
Jo VY, Antonescu CR, Zhang L, Dal Cin P, Hornick JL, Fletcher CD
Am J Surg Pathol 2013 May;37(5):710-8. doi: 10.1097/PAS.0b013e3182772bba. PMID: 23588365Free PMC Article
Doyle LA, Wang WL, Dal Cin P, Lopez-Terrada D, Mertens F, Lazar AJ, Fletcher CD, Hornick JL
Am J Surg Pathol 2012 Oct;36(10):1444-51. doi: 10.1097/PAS.0b013e3182562bf8. PMID: 22982887
Doyle LA, Möller E, Dal Cin P, Fletcher CD, Mertens F, Hornick JL
Am J Surg Pathol 2011 May;35(5):733-41. doi: 10.1097/PAS.0b013e318210c268. PMID: 21415703

Prognosis

Zhang Y, Wan D, Gao F
Hum Pathol 2018 Sep;79:208-211. Epub 2018 Feb 25 doi: 10.1016/j.humpath.2018.02.013. PMID: 29486291
Ban LK, Tseng AH, Huang SH, Lee HH
World J Surg Oncol 2017 May 30;15(1):109. doi: 10.1186/s12957-017-1174-8. PMID: 28558780Free PMC Article
Matsumura T, Yamaguchi T, Tochigi N, Wada T, Yamashita T, Hasegawa T
J Clin Pathol 2010 Feb;63(2):124-8. doi: 10.1136/jcp.2009.072256. PMID: 20154033

Clinical prediction guides

Zhang Y, Wan D, Gao F
Hum Pathol 2018 Sep;79:208-211. Epub 2018 Feb 25 doi: 10.1016/j.humpath.2018.02.013. PMID: 29486291
Vallejo-Benítez A, Rodríguez-Zarco E, Carrasco SP, Pereira-Gallardo S, Brugal Molina J, García-Escudero A, Robles Frías A, Marcilla D, González-Cámpora R
Ann Diagn Pathol 2017 Oct;30:8-11. Epub 2017 May 11 doi: 10.1016/j.anndiagpath.2017.05.002. PMID: 28965630
Doyle LA, Wang WL, Dal Cin P, Lopez-Terrada D, Mertens F, Lazar AJ, Fletcher CD, Hornick JL
Am J Surg Pathol 2012 Oct;36(10):1444-51. doi: 10.1097/PAS.0b013e3182562bf8. PMID: 22982887
Matsumura T, Yamaguchi T, Tochigi N, Wada T, Yamashita T, Hasegawa T
J Clin Pathol 2010 Feb;63(2):124-8. doi: 10.1136/jcp.2009.072256. PMID: 20154033

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