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Refractory Ocular Melanoma

MedGen UID:
1775859
•Concept ID:
C5420146
•
Neoplastic Process

Definition

Ocular melanoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ocular Melanoma

Professional guidelines

PubMed

Glaucoma secondary to intraocular tumors: mechanisms and management.
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240
Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma.
Lane AM, Kim IK, Gragoudas ES
JAMA Ophthalmol 2018 Sep 1;136(9):981-986. doi: 10.1001/jamaophthalmol.2018.2466. PMID: 29955797Free PMC Article
Current status of isolated hepatic perfusion with or without tumor necrosis factor for the treatment of unresectable cancers confined to liver.
Alexander HR Jr, Bartlett DL, Libutti SK
Oncologist 2000;5(5):416-24. doi: 10.1634/theoncologist.5-5-416. PMID: 11040278

Recent clinical studies

Etiology

Cauda equina syndrome as the initial presentation of uveal melanoma metastasis.
Hanout M, Kamil ZS, Alrjoub M, Laperriere N, Altomare F, Krema H
Eur J Ophthalmol 2022 Jan;32(1):NP1-NP4. Epub 2020 Jul 22 doi: 10.1177/1120672120944799. PMID: 32700563
Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma.
Lane AM, Kim IK, Gragoudas ES
JAMA Ophthalmol 2018 Sep 1;136(9):981-986. doi: 10.1001/jamaophthalmol.2018.2466. PMID: 29955797Free PMC Article
Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study.
Chandran SS, Somerville RPT, Yang JC, Sherry RM, Klebanoff CA, Goff SL, Wunderlich JR, Danforth DN, Zlott D, Paria BC, Sabesan AC, Srivastava AK, Xi L, Pham TH, Raffeld M, White DE, Toomey MA, Rosenberg SA, Kammula US
Lancet Oncol 2017 Jun;18(6):792-802. Epub 2017 Apr 7 doi: 10.1016/S1470-2045(17)30251-6. PMID: 28395880Free PMC Article
Isolated hepatic perfusion for ocular melanoma metastasis: registry data suggests a survival benefit.
Olofsson R, Cahlin C, All-Ericsson C, Hashimi F, Mattsson J, Rizell M, Lindnér P
Ann Surg Oncol 2014 Feb;21(2):466-72. Epub 2013 Oct 19 doi: 10.1245/s10434-013-3304-z. PMID: 24141377
The past decade of experience with isolated hepatic perfusion.
Grover A, Alexander HR Jr
Oncologist 2004;9(6):653-64. doi: 10.1634/theoncologist.9-6-653. PMID: 15561809

Diagnosis

Cauda equina syndrome as the initial presentation of uveal melanoma metastasis.
Hanout M, Kamil ZS, Alrjoub M, Laperriere N, Altomare F, Krema H
Eur J Ophthalmol 2022 Jan;32(1):NP1-NP4. Epub 2020 Jul 22 doi: 10.1177/1120672120944799. PMID: 32700563
Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma.
Lane AM, Kim IK, Gragoudas ES
JAMA Ophthalmol 2018 Sep 1;136(9):981-986. doi: 10.1001/jamaophthalmol.2018.2466. PMID: 29955797Free PMC Article
Secondary Glaucoma due to Iridescent Crystalline Particles Masquerading as Refractory Hypertensive Uveitis in an Eye With Irradiated Iris Melanoma.
Chahal R, Mohite AA, Heimann H, Bansal A
J Glaucoma 2018 Apr;27(4):385-388. doi: 10.1097/IJG.0000000000000891. PMID: 29394206
Ring melanoma--a rare cause of refractory glaucoma.
Lee V, Cree IA, Hungerford JL
Br J Ophthalmol 1999 Feb;83(2):194-8. doi: 10.1136/bjo.83.2.194. PMID: 10396198Free PMC Article
Ciliary body melanoma masquerading as chronic uveitis.
Nguyen QD, Foster CS
Ocul Immunol Inflamm 1998 Dec;6(4):253-6. doi: 10.1076/ocii.6.4.253.4031. PMID: 9924921

Therapy

Glaucoma secondary to intraocular tumors: mechanisms and management.
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240
Treatment of metastatic uveal melanoma with adoptive transfer of tumour-infiltrating lymphocytes: a single-centre, two-stage, single-arm, phase 2 study.
Chandran SS, Somerville RPT, Yang JC, Sherry RM, Klebanoff CA, Goff SL, Wunderlich JR, Danforth DN, Zlott D, Paria BC, Sabesan AC, Srivastava AK, Xi L, Pham TH, Raffeld M, White DE, Toomey MA, Rosenberg SA, Kammula US
Lancet Oncol 2017 Jun;18(6):792-802. Epub 2017 Apr 7 doi: 10.1016/S1470-2045(17)30251-6. PMID: 28395880Free PMC Article
Current treatments for radiation retinopathy.
Giuliari GP, Sadaka A, Hinkle DM, Simpson ER
Acta Oncol 2011 Jan;50(1):6-13. Epub 2010 Aug 20 doi: 10.3109/0284186X.2010.500299. PMID: 20722590
The past decade of experience with isolated hepatic perfusion.
Grover A, Alexander HR Jr
Oncologist 2004;9(6):653-64. doi: 10.1634/theoncologist.9-6-653. PMID: 15561809
Current status of isolated hepatic perfusion with or without tumor necrosis factor for the treatment of unresectable cancers confined to liver.
Alexander HR Jr, Bartlett DL, Libutti SK
Oncologist 2000;5(5):416-24. doi: 10.1634/theoncologist.5-5-416. PMID: 11040278

Prognosis

Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma.
Lane AM, Kim IK, Gragoudas ES
JAMA Ophthalmol 2018 Sep 1;136(9):981-986. doi: 10.1001/jamaophthalmol.2018.2466. PMID: 29955797Free PMC Article
Isolated hepatic perfusion for ocular melanoma metastasis: registry data suggests a survival benefit.
Olofsson R, Cahlin C, All-Ericsson C, Hashimi F, Mattsson J, Rizell M, Lindnér P
Ann Surg Oncol 2014 Feb;21(2):466-72. Epub 2013 Oct 19 doi: 10.1245/s10434-013-3304-z. PMID: 24141377
Phase I/II randomized trial of intrahepatic arterial infusion chemotherapy with cisplatin and chemoembolization with cisplatin and polyvinyl sponge in patients with ocular melanoma metastatic to the liver.
Agarwala SS, Panikkar R, Kirkwood JM
Melanoma Res 2004 Jun;14(3):217-22. doi: 10.1097/01.cmr.0000129377.22141.ea. PMID: 15179192
Intravenous administration of recombinant human macrophage colony-stimulating factor to patients with metastatic cancer: a phase I study.
Sanda MG, Yang JC, Topalian SL, Groves ES, Childs A, Belfort R Jr, de Smet MD, Schwartzentruber DJ, White DE, Lotze MT
J Clin Oncol 1992 Oct;10(10):1643-9. doi: 10.1200/JCO.1992.10.10.1643. PMID: 1403042

Clinical prediction guides

Cauda equina syndrome as the initial presentation of uveal melanoma metastasis.
Hanout M, Kamil ZS, Alrjoub M, Laperriere N, Altomare F, Krema H
Eur J Ophthalmol 2022 Jan;32(1):NP1-NP4. Epub 2020 Jul 22 doi: 10.1177/1120672120944799. PMID: 32700563
Survival Rates in Patients After Treatment for Metastasis From Uveal Melanoma.
Lane AM, Kim IK, Gragoudas ES
JAMA Ophthalmol 2018 Sep 1;136(9):981-986. doi: 10.1001/jamaophthalmol.2018.2466. PMID: 29955797Free PMC Article
Hepatic yttrium-90 radioembolization for metastatic melanoma: a single-center experience.
Memon K, Kuzel TM, Vouche M, Atassi R, Lewandowski RJ, Salem R
Melanoma Res 2014 Jun;24(3):244-51. doi: 10.1097/CMR.0000000000000051. PMID: 24638152
Isolation perfusion of the liver.
Carroll NM, Alexander HR Jr
Cancer J 2002 Mar-Apr;8(2):181-93. doi: 10.1097/00130404-200203000-00012. PMID: 12004803
Intravenous administration of recombinant human macrophage colony-stimulating factor to patients with metastatic cancer: a phase I study.
Sanda MG, Yang JC, Topalian SL, Groves ES, Childs A, Belfort R Jr, de Smet MD, Schwartzentruber DJ, White DE, Lotze MT
J Clin Oncol 1992 Oct;10(10):1643-9. doi: 10.1200/JCO.1992.10.10.1643. PMID: 1403042

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