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Refractory Intrahepatic Cholangiocarcinoma

MedGen UID:
1775959
Concept ID:
C5420667
Neoplastic Process

Definition

Intrahepatic cholangiocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Intrahepatic Cholangiocarcinoma

Professional guidelines

PubMed

Goerg F, Zimmermann M, Bruners P, Neumann U, Luedde T, Kuhl C
Cardiovasc Intervent Radiol 2019 Dec;42(12):1709-1717. Epub 2019 Oct 2 doi: 10.1007/s00270-019-02344-0. PMID: 31578633

Recent clinical studies

Etiology

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Lee CK, Chon HJ, Cheon J, Lee MA, Im HS, Jang JS, Kim MH, Park S, Kang B, Hong M, Kim JW, Park HS, Kang MJ, Park YN, Choi HJ
Lancet Gastroenterol Hepatol 2023 Jan;8(1):56-65. Epub 2022 Oct 31 doi: 10.1016/S2468-1253(22)00335-1. PMID: 36328033
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
Javle M, Lowery M, Shroff RT, Weiss KH, Springfeld C, Borad MJ, Ramanathan RK, Goyal L, Sadeghi S, Macarulla T, El-Khoueiry A, Kelley RK, Borbath I, Choo SP, Oh DY, Philip PA, Chen LT, Reungwetwattana T, Van Cutsem E, Yeh KH, Ciombor K, Finn RS, Patel A, Sen S, Porter D, Isaacs R, Zhu AX, Abou-Alfa GK, Bekaii-Saab T
J Clin Oncol 2018 Jan 20;36(3):276-282. Epub 2017 Nov 28 doi: 10.1200/JCO.2017.75.5009. PMID: 29182496Free PMC Article
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D
Nat Rev Gastroenterol Hepatol 2016 May;13(5):261-80. Epub 2016 Apr 20 doi: 10.1038/nrgastro.2016.51. PMID: 27095655

Diagnosis

Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D
World J Gastroenterol 2020 Jul 7;26(25):3542-3561. doi: 10.3748/wjg.v26.i25.3542. PMID: 32742125Free PMC Article
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Rizvi S, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D
Nat Rev Gastroenterol Hepatol 2016 May;13(5):261-80. Epub 2016 Apr 20 doi: 10.1038/nrgastro.2016.51. PMID: 27095655
Jagadisan B, Srivastava A
Indian J Pediatr 2016 Nov;83(11):1311-1320. Epub 2016 Mar 2 doi: 10.1007/s12098-016-2058-6. PMID: 26932879

Therapy

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Subbiah V, Iannotti NO, Gutierrez M, Smith DC, Féliz L, Lihou CF, Tian C, Silverman IM, Ji T, Saleh M
Ann Oncol 2022 May;33(5):522-533. Epub 2022 Feb 14 doi: 10.1016/j.annonc.2022.02.001. PMID: 35176457
Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D
World J Gastroenterol 2020 Jul 7;26(25):3542-3561. doi: 10.3748/wjg.v26.i25.3542. PMID: 32742125Free PMC Article
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D
Nat Rev Gastroenterol Hepatol 2016 May;13(5):261-80. Epub 2016 Apr 20 doi: 10.1038/nrgastro.2016.51. PMID: 27095655

Prognosis

Carapeto F, Bozorgui B, Shroff RT, Chagani S, Solis Soto L, Foo WC, Wistuba I, Meric-Bernstam F, Shalaby A, Javle M, Korkut A, Kwong LN
Hepatology 2022 Feb;75(2):297-308. Epub 2021 Dec 6 doi: 10.1002/hep.32150. PMID: 34510503Free PMC Article
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831
Saito Y, Muramatsu T, Kanai Y, Ojima H, Sukeda A, Hiraoka N, Arai E, Sugiyama Y, Matsuzaki J, Uchida R, Yoshikawa N, Furukawa R, Saito H
Cell Rep 2019 Apr 23;27(4):1265-1276.e4. doi: 10.1016/j.celrep.2019.03.088. PMID: 31018139
Andersen JB, Thorgeirsson SS
Curr Opin Gastroenterol 2012 May;28(3):266-72. doi: 10.1097/MOG.0b013e3283523c7e. PMID: 22395571Free PMC Article
Berr F
Semin Liver Dis 2004 May;24(2):177-87. doi: 10.1055/s-2004-828894. PMID: 15192790

Clinical prediction guides

Lee CK, Chon HJ, Cheon J, Lee MA, Im HS, Jang JS, Kim MH, Park S, Kang B, Hong M, Kim JW, Park HS, Kang MJ, Park YN, Choi HJ
Lancet Gastroenterol Hepatol 2023 Jan;8(1):56-65. Epub 2022 Oct 31 doi: 10.1016/S2468-1253(22)00335-1. PMID: 36328033
Bahleda R, Meric-Bernstam F, Goyal L, Tran B, He Y, Yamamiya I, Benhadji KA, Matos I, Arkenau HT
Ann Oncol 2020 Oct;31(10):1405-1412. Epub 2020 Jul 2 doi: 10.1016/j.annonc.2020.06.018. PMID: 32622884Free PMC Article
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
White J, Carolan-Rees G, Dale M, Patrick HE, See TC, Bell JK, Manas DM, Crellin A, Slevin NJ, Sharma RA
J Vasc Interv Radiol 2019 Aug;30(8):1185-1192. Epub 2019 Jun 27 doi: 10.1016/j.jvir.2019.03.018. PMID: 31255499
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831

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