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Refractory Intrahepatic Cholangiocarcinoma

MedGen UID:
1775959
Concept ID:
C5420667
Neoplastic Process

Definition

Intrahepatic cholangiocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Intrahepatic Cholangiocarcinoma

Professional guidelines

PubMed

Goerg F, Zimmermann M, Bruners P, Neumann U, Luedde T, Kuhl C
Cardiovasc Intervent Radiol 2019 Dec;42(12):1709-1717. Epub 2019 Oct 2 doi: 10.1007/s00270-019-02344-0. PMID: 31578633

Recent clinical studies

Etiology

Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Lee CK, Chon HJ, Cheon J, Lee MA, Im HS, Jang JS, Kim MH, Park S, Kang B, Hong M, Kim JW, Park HS, Kang MJ, Park YN, Choi HJ
Lancet Gastroenterol Hepatol 2023 Jan;8(1):56-65. Epub 2022 Oct 31 doi: 10.1016/S2468-1253(22)00335-1. PMID: 36328033
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D
Nat Rev Gastroenterol Hepatol 2016 May;13(5):261-80. Epub 2016 Apr 20 doi: 10.1038/nrgastro.2016.51. PMID: 27095655
Andersen JB, Thorgeirsson SS
Curr Opin Gastroenterol 2012 May;28(3):266-72. doi: 10.1097/MOG.0b013e3283523c7e. PMID: 22395571Free PMC Article

Diagnosis

Bragazzi MC, Venere R, Ribichini E, Covotta F, Cardinale V, Alvaro D
Dig Liver Dis 2024 Mar;56(3):383-393. Epub 2023 Sep 16 doi: 10.1016/j.dld.2023.08.052. PMID: 37722960
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D
Nat Rev Gastroenterol Hepatol 2016 May;13(5):261-80. Epub 2016 Apr 20 doi: 10.1038/nrgastro.2016.51. PMID: 27095655
Jagadisan B, Srivastava A
Indian J Pediatr 2016 Nov;83(11):1311-1320. Epub 2016 Mar 2 doi: 10.1007/s12098-016-2058-6. PMID: 26932879

Therapy

Limousin W, Laurent-Puig P, Ziol M, Ganne-Carrié N, Nahon P, Ait-Omar A, Seror O, Sidali S, Campani C, Blanc P, Lermine A, Marisa L, Zucman-Rossi J, Nault JC
J Hepatol 2023 Dec;79(6):1450-1458. Epub 2023 Aug 28 doi: 10.1016/j.jhep.2023.08.017. PMID: 37647991
Javle M, King G, Spencer K, Borad MJ
Oncologist 2023 Nov 2;28(11):928-943. doi: 10.1093/oncolo/oyad149. PMID: 37390492Free PMC Article
Dasari A, Lonardi S, Garcia-Carbonero R, Elez E, Yoshino T, Sobrero A, Yao J, García-Alfonso P, Kocsis J, Cubillo Gracian A, Sartore-Bianchi A, Satoh T, Randrian V, Tomasek J, Chong G, Paulson AS, Masuishi T, Jones J, Csőszi T, Cremolini C, Ghiringhelli F, Shergill A, Hochster HS, Krauss J, Bassam A, Ducreux M, Elme A, Faugeras L, Kasper S, Van Cutsem E, Arnold D, Nanda S, Yang Z, Schelman WR, Kania M, Tabernero J, Eng C; FRESCO-2 Study Investigators
Lancet 2023 Jul 1;402(10395):41-53. Epub 2023 Jun 15 doi: 10.1016/S0140-6736(23)00772-9. PMID: 37331369
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D
Nat Rev Gastroenterol Hepatol 2016 May;13(5):261-80. Epub 2016 Apr 20 doi: 10.1038/nrgastro.2016.51. PMID: 27095655

Prognosis

Li J, Xu X, Xu K, Zhou X, Wu K, Yao Y, Liu Z, Chen C, Wang L, Sun Z, Jiao D, Han X
J Exp Clin Cancer Res 2024 Apr 20;43(1):119. doi: 10.1186/s13046-024-03006-x. PMID: 38641828Free PMC Article
Carapeto F, Bozorgui B, Shroff RT, Chagani S, Solis Soto L, Foo WC, Wistuba I, Meric-Bernstam F, Shalaby A, Javle M, Korkut A, Kwong LN
Hepatology 2022 Feb;75(2):297-308. Epub 2021 Dec 6 doi: 10.1002/hep.32150. PMID: 34510503Free PMC Article
Lin J, Cao Y, Yang X, Li G, Shi Y, Wang D, Long J, Song Y, Mao J, Xie F, Bai Y, Zhang L, Yang X, Wan X, Wang A, Guan M, Zhao L, Hu K, Pan J, Huo L, Lu X, Mao Y, Sang X, Zhang H, Wang K, Wang X, Zhao H
Theranostics 2021;11(10):4585-4598. Epub 2021 Mar 4 doi: 10.7150/thno.56539. PMID: 33754015Free PMC Article
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831
Andersen JB, Thorgeirsson SS
Curr Opin Gastroenterol 2012 May;28(3):266-72. doi: 10.1097/MOG.0b013e3283523c7e. PMID: 22395571Free PMC Article

Clinical prediction guides

Limousin W, Laurent-Puig P, Ziol M, Ganne-Carrié N, Nahon P, Ait-Omar A, Seror O, Sidali S, Campani C, Blanc P, Lermine A, Marisa L, Zucman-Rossi J, Nault JC
J Hepatol 2023 Dec;79(6):1450-1458. Epub 2023 Aug 28 doi: 10.1016/j.jhep.2023.08.017. PMID: 37647991
Javle M, King G, Spencer K, Borad MJ
Oncologist 2023 Nov 2;28(11):928-943. doi: 10.1093/oncolo/oyad149. PMID: 37390492Free PMC Article
Lee CK, Chon HJ, Cheon J, Lee MA, Im HS, Jang JS, Kim MH, Park S, Kang B, Hong M, Kim JW, Park HS, Kang MJ, Park YN, Choi HJ
Lancet Gastroenterol Hepatol 2023 Jan;8(1):56-65. Epub 2022 Oct 31 doi: 10.1016/S2468-1253(22)00335-1. PMID: 36328033
Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Whisenant J, Lowery MA, Goyal L, Shroff RT, El-Khoueiry AB, Fan B, Wu B, Chamberlain CX, Jiang L, Gliser C, Pandya SS, Valle JW, Zhu AX
Lancet Oncol 2020 Jun;21(6):796-807. Epub 2020 May 13 doi: 10.1016/S1470-2045(20)30157-1. PMID: 32416072Free PMC Article
Bahleda R, Italiano A, Hierro C, Mita A, Cervantes A, Chan N, Awad M, Calvo E, Moreno V, Govindan R, Spira A, Gonzalez M, Zhong B, Santiago-Walker A, Poggesi I, Parekh T, Xie H, Infante J, Tabernero J
Clin Cancer Res 2019 Aug 15;25(16):4888-4897. Epub 2019 May 14 doi: 10.1158/1078-0432.CCR-18-3334. PMID: 31088831

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