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Refractory Vulvar Carcinoma

MedGen UID:
1775979
•Concept ID:
C5420821
•
Neoplastic Process

Definition

Vulvar carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Vulvar Carcinoma

Professional guidelines

PubMed

Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Treatment of human papillomavirus-associated vulvar disease with the CO2-laser. Physical and histological aspects with use of a new scanning device, the SwiftLase.
Spörri S, Frenz M, Altermatt HJ, Hannigan EV, Dreher E
Arch Gynecol Obstet 1996;259(1):25-35. doi: 10.1007/BF02505305. PMID: 8933926

Recent clinical studies

Etiology

Efficacy and safety of HpD-PDT for Extramammary Paget's Disease refractory to conventional therapy: A prospective, open-label and single arm pilot study.
Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272
Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease.
Hirai I, Tanese K, Nakamura Y, Ishii M, Kawakami Y, Funakoshi T
Oncologist 2019 Jun;24(6):e394-e396. Epub 2019 Mar 7 doi: 10.1634/theoncologist.2018-0856. PMID: 30846514Free PMC Article
Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.
Molina GE, Khalifian S, Mull JL, Chen L, Rosman IS, Faulkner-Jones BE, Ngo KH, Demehri S, Cornelius LA, Wu PA
JAMA Dermatol 2019 May 1;155(5):599-603. doi: 10.1001/jamadermatol.2018.4793. PMID: 30785593Free PMC Article
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Human papillomavirus-related genital disease in the immunocompromised host: Part II.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):883.e1-17; quiz 899-900. doi: 10.1016/j.jaad.2010.12.049. PMID: 22583721

Diagnosis

Case Report: Intra-Tumoral Vaccinations of Quadrivalent HPV-L1 Peptide Vaccine With Topical TLR-7 Agonist Following Recurrence: Complete Resolution of HPV-HR-Associated Gynecologic Squamous Cell Carcinomas in Two Patients.
Reedy M, Jonnalagadda S, Palle K
Pathol Oncol Res 2021;27:1609922. Epub 2021 Dec 20 doi: 10.3389/pore.2021.1609922. PMID: 34987310Free PMC Article
Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease.
Hirai I, Tanese K, Nakamura Y, Ishii M, Kawakami Y, Funakoshi T
Oncologist 2019 Jun;24(6):e394-e396. Epub 2019 Mar 7 doi: 10.1634/theoncologist.2018-0856. PMID: 30846514Free PMC Article
Genital pyoderma gangrenosum: report of two cases and published work review of Japanese cases.
Satoh M, Yamamoto T
J Dermatol 2013 Oct;40(10):840-3. Epub 2013 Aug 21 doi: 10.1111/1346-8138.12252. PMID: 24033392
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Differential responses of EGFR-/AGT-expressing cells to the "combi-triazene" SMA41.
Matheson SL, McNamee JP, Jean-Claude BJ
Cancer Chemother Pharmacol 2003 Jan;51(1):11-20. Epub 2002 Nov 22 doi: 10.1007/s00280-002-0525-4. PMID: 12497201

Therapy

Efficacy and safety of HpD-PDT for Extramammary Paget's Disease refractory to conventional therapy: A prospective, open-label and single arm pilot study.
Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272
Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease.
Hirai I, Tanese K, Nakamura Y, Ishii M, Kawakami Y, Funakoshi T
Oncologist 2019 Jun;24(6):e394-e396. Epub 2019 Mar 7 doi: 10.1634/theoncologist.2018-0856. PMID: 30846514Free PMC Article
Topical Combination of Fluorouracil and Calcipotriene as a Palliative Therapy for Refractory Extramammary Paget Disease.
Molina GE, Khalifian S, Mull JL, Chen L, Rosman IS, Faulkner-Jones BE, Ngo KH, Demehri S, Cornelius LA, Wu PA
JAMA Dermatol 2019 May 1;155(5):599-603. doi: 10.1001/jamadermatol.2018.4793. PMID: 30785593Free PMC Article
Diagnosis and treatment of lichen sclerosus: an update.
Fistarol SK, Itin PH
Am J Clin Dermatol 2013 Feb;14(1):27-47. doi: 10.1007/s40257-012-0006-4. PMID: 23329078Free PMC Article
Human papillomavirus-related genital disease in the immunocompromised host: Part II.
Gormley RH, Kovarik CL
J Am Acad Dermatol 2012 Jun;66(6):883.e1-17; quiz 899-900. doi: 10.1016/j.jaad.2010.12.049. PMID: 22583721

Prognosis

Efficacy and safety of HpD-PDT for Extramammary Paget's Disease refractory to conventional therapy: A prospective, open-label and single arm pilot study.
Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272
Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease.
Hirai I, Tanese K, Nakamura Y, Ishii M, Kawakami Y, Funakoshi T
Oncologist 2019 Jun;24(6):e394-e396. Epub 2019 Mar 7 doi: 10.1634/theoncologist.2018-0856. PMID: 30846514Free PMC Article
Dermo Beta Brachytherapy with 188Re in extramammary Paget's disease.
Carrozzo AM, Cipriani C, Donati P, Muscardin L, Sedda AF
G Ital Dermatol Venereol 2014 Feb;149(1):115-21. PMID: 24566572

Clinical prediction guides

Efficacy and safety of HpD-PDT for Extramammary Paget's Disease refractory to conventional therapy: A prospective, open-label and single arm pilot study.
Wang D, Wang P, Li C, Zhou Z, Zhang L, Zhang G, Wang X
Photodiagnosis Photodyn Ther 2022 Mar;37:102670. Epub 2021 Dec 7 doi: 10.1016/j.pdpdt.2021.102670. PMID: 34883272

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