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COVID-19-Associated Nervous System Disorder

MedGen UID:
1776032
•Concept ID:
C5419165
•
Disease or Syndrome
Synonym: SARS-CoV-2 -Associated Nervous System Disorder

Definition

A central or peripheral nervous system disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [from NCI]

Professional guidelines

PubMed

Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management.
Sampaio Rocha-Filho PA
Headache 2022 Jun;62(6):650-656. Epub 2022 May 11 doi: 10.1111/head.14319. PMID: 35545780Free PMC Article
Mucormycosis in COVID-19 patients: predisposing factors, prevention and management.
Rudrabhatla PK, Reghukumar A, Thomas SV
Acta Neurol Belg 2022 Apr;122(2):273-280. Epub 2021 Nov 24 doi: 10.1007/s13760-021-01840-w. PMID: 34820787Free PMC Article
Treatment considerations for Behçet disease in the era of COVID-19: A narrative review.
Elmas ÖF, Demirbaş A, Bağcıer F, Türsen Ü, Atasoy M, Dursun R, Lotti T
Dermatol Ther 2021 Jan;34(1):e14507. Epub 2020 Nov 9 doi: 10.1111/dth.14507. PMID: 33150651

Recent clinical studies

Etiology

Malnutrition and Sarcopenia in COVID-19 Survivors.
Grund S, Bauer JM
Clin Geriatr Med 2022 Aug;38(3):559-564. Epub 2022 Apr 21 doi: 10.1016/j.cger.2022.04.001. PMID: 35868673Free PMC Article
Neurological Sequelae of COVID-19.
Ahmad SJ, Feigen CM, Vazquez JP, Kobets AJ, Altschul DJ
J Integr Neurosci 2022 Apr 6;21(3):77. doi: 10.31083/j.jin2103077. PMID: 35633158
COVID-19 associated cognitive impairment: A systematic review.
Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P
Cortex 2022 Jul;152:77-97. Epub 2022 Apr 18 doi: 10.1016/j.cortex.2022.04.006. PMID: 35537236Free PMC Article
COVID-19 and the peripheral nervous system. A 2-year review from the pandemic to the vaccine era.
Taga A, Lauria G
J Peripher Nerv Syst 2022 Mar;27(1):4-30. Epub 2022 Mar 14 doi: 10.1111/jns.12482. PMID: 35137496Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article

Diagnosis

Encephalitis in Patients with COVID-19: A Systematic Evidence-Based Analysis.
Islam MA, Cavestro C, Alam SS, Kundu S, Kamal MA, Reza F
Cells 2022 Aug 18;11(16) doi: 10.3390/cells11162575. PMID: 36010650Free PMC Article
COVID-19 associated myopathy.
Aschman T, Stenzel W
Curr Opin Neurol 2022 Oct 1;35(5):622-628. Epub 2022 Aug 11 doi: 10.1097/WCO.0000000000001101. PMID: 35950722
Central neuroinflammation in Covid-19: a systematic review of 182 cases with encephalitis, acute disseminated encephalomyelitis, and necrotizing encephalopathies.
Zamani R, Pouremamali R, Rezaei N
Rev Neurosci 2022 Jun 27;33(4):397-412. Epub 2021 Sep 17 doi: 10.1515/revneuro-2021-0082. PMID: 34536341
Stroke in patients with COVID-19: Clinical and neuroimaging characteristics.
Vogrig A, Gigli GL, Bnà C, Morassi M
Neurosci Lett 2021 Jan 19;743:135564. Epub 2020 Dec 19 doi: 10.1016/j.neulet.2020.135564. PMID: 33352277Free PMC Article
COVID-19-associated Guillain-Barré syndrome: The early pandemic experience.
Caress JB, Castoro RJ, Simmons Z, Scelsa SN, Lewis RA, Ahlawat A, Narayanaswami P
Muscle Nerve 2020 Oct;62(4):485-491. Epub 2020 Aug 11 doi: 10.1002/mus.27024. PMID: 32678460Free PMC Article

Therapy

COVID-19 and the peripheral nervous system. A 2-year review from the pandemic to the vaccine era.
Taga A, Lauria G
J Peripher Nerv Syst 2022 Mar;27(1):4-30. Epub 2022 Mar 14 doi: 10.1111/jns.12482. PMID: 35137496Free PMC Article
COVID-19-associated Guillain-Barre syndrome: Postinfectious alone or neuroinvasive too?
Khan F, Sharma P, Pandey S, Sharma D, V V, Kumar N, Shukla S, Dandu H, Jain A, Garg RK, Malhotra HS
J Med Virol 2021 Oct;93(10):6045-6049. Epub 2021 Jul 6 doi: 10.1002/jmv.27159. PMID: 34170552Free PMC Article
Acute Transverse Myelitis (ATM):Clinical Review of 43 Patients With COVID-19-Associated ATM and 3 Post-Vaccination ATM Serious Adverse Events With the ChAdOx1 nCoV-19 Vaccine (AZD1222).
Román GC, Gracia F, Torres A, Palacios A, Gracia K, Harris D
Front Immunol 2021;12:653786. Epub 2021 Apr 26 doi: 10.3389/fimmu.2021.653786. PMID: 33981305Free PMC Article
Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: A systematic review and meta-analysis.
Palaiodimou L, Stefanou MI, Katsanos AH, Fragkou PC, Papadopoulou M, Moschovos C, Michopoulos I, Kokotis P, Bakirtzis C, Naska A, Vassilakopoulos TI, Chroni E, Tsiodras S, Tsivgoulis G
Eur J Neurol 2021 Oct;28(10):3517-3529. Epub 2021 Apr 28 doi: 10.1111/ene.14860. PMID: 33837630Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article

Prognosis

COVID-19 and Cerebrovascular Disease.
Catherine C, Veitinger J, Chou SH
Semin Neurol 2023 Apr;43(2):219-228. Epub 2023 May 22 doi: 10.1055/s-0043-1768475. PMID: 37216977
Encephalitis in Patients with COVID-19: A Systematic Evidence-Based Analysis.
Islam MA, Cavestro C, Alam SS, Kundu S, Kamal MA, Reza F
Cells 2022 Aug 18;11(16) doi: 10.3390/cells11162575. PMID: 36010650Free PMC Article
Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: A systematic review and meta-analysis.
Palaiodimou L, Stefanou MI, Katsanos AH, Fragkou PC, Papadopoulou M, Moschovos C, Michopoulos I, Kokotis P, Bakirtzis C, Naska A, Vassilakopoulos TI, Chroni E, Tsiodras S, Tsivgoulis G
Eur J Neurol 2021 Oct;28(10):3517-3529. Epub 2021 Apr 28 doi: 10.1111/ene.14860. PMID: 33837630Free PMC Article
Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M
J Neurol 2021 Apr;268(4):1133-1170. Epub 2020 Aug 25 doi: 10.1007/s00415-020-10124-x. PMID: 32840686Free PMC Article
COVID-19-associated Guillain-Barré syndrome: The early pandemic experience.
Caress JB, Castoro RJ, Simmons Z, Scelsa SN, Lewis RA, Ahlawat A, Narayanaswami P
Muscle Nerve 2020 Oct;62(4):485-491. Epub 2020 Aug 11 doi: 10.1002/mus.27024. PMID: 32678460Free PMC Article

Clinical prediction guides

Encephalitis in Patients with COVID-19: A Systematic Evidence-Based Analysis.
Islam MA, Cavestro C, Alam SS, Kundu S, Kamal MA, Reza F
Cells 2022 Aug 18;11(16) doi: 10.3390/cells11162575. PMID: 36010650Free PMC Article
COVID-19 associated cognitive impairment: A systematic review.
Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P
Cortex 2022 Jul;152:77-97. Epub 2022 Apr 18 doi: 10.1016/j.cortex.2022.04.006. PMID: 35537236Free PMC Article
COVID-19 associated nervous system manifestations.
Khatoon F, Prasad K, Kumar V
Sleep Med 2022 Mar;91:231-236. Epub 2021 Jul 9 doi: 10.1016/j.sleep.2021.07.005. PMID: 34321155Free PMC Article
Cardiovascular complications of COVID-19.
Farshidfar F, Koleini N, Ardehali H
JCI Insight 2021 Jul 8;6(13) doi: 10.1172/jci.insight.148980. PMID: 34061779Free PMC Article
Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: A systematic review and meta-analysis.
Palaiodimou L, Stefanou MI, Katsanos AH, Fragkou PC, Papadopoulou M, Moschovos C, Michopoulos I, Kokotis P, Bakirtzis C, Naska A, Vassilakopoulos TI, Chroni E, Tsiodras S, Tsivgoulis G
Eur J Neurol 2021 Oct;28(10):3517-3529. Epub 2021 Apr 28 doi: 10.1111/ene.14860. PMID: 33837630Free PMC Article

Recent systematic reviews

Encephalitis in Patients with COVID-19: A Systematic Evidence-Based Analysis.
Islam MA, Cavestro C, Alam SS, Kundu S, Kamal MA, Reza F
Cells 2022 Aug 18;11(16) doi: 10.3390/cells11162575. PMID: 36010650Free PMC Article
COVID-19 associated cognitive impairment: A systematic review.
Tavares-Júnior JWL, de Souza ACC, Borges JWP, Oliveira DN, Siqueira-Neto JI, Sobreira-Neto MA, Braga-Neto P
Cortex 2022 Jul;152:77-97. Epub 2022 Apr 18 doi: 10.1016/j.cortex.2022.04.006. PMID: 35537236Free PMC Article
Prevalence, clinical characteristics and outcomes of Guillain-Barré syndrome spectrum associated with COVID-19: A systematic review and meta-analysis.
Palaiodimou L, Stefanou MI, Katsanos AH, Fragkou PC, Papadopoulou M, Moschovos C, Michopoulos I, Kokotis P, Bakirtzis C, Naska A, Vassilakopoulos TI, Chroni E, Tsiodras S, Tsivgoulis G
Eur J Neurol 2021 Oct;28(10):3517-3529. Epub 2021 Apr 28 doi: 10.1111/ene.14860. PMID: 33837630Free PMC Article
Stroke in COVID-19: A systematic review and meta-analysis.
Nannoni S, de Groot R, Bell S, Markus HS
Int J Stroke 2021 Feb;16(2):137-149. Epub 2020 Nov 11 doi: 10.1177/1747493020972922. PMID: 33103610Free PMC Article
Guillain-Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M
J Neurol 2021 Apr;268(4):1133-1170. Epub 2020 Aug 25 doi: 10.1007/s00415-020-10124-x. PMID: 32840686Free PMC Article

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