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Unresectable Hypopharyngeal Squamous Cell Carcinoma

MedGen UID:
1777191
•Concept ID:
C5419759
•
Neoplastic Process

Definition

Hypopharyngeal squamous cell carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Hypopharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Neck management in head and neck squamous cell carcinomas: where do we stand?
Klausner G, Troussier I, Blais E, Carsuzaa F, Zilli T, Miralbell R, Caparrotti F, Thariat J
Med Oncol 2019 Mar 27;36(5):40. doi: 10.1007/s12032-019-1265-1. PMID: 30919135
Japanese Clinical Practice Guideline for Head and Neck Cancer.
Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T
Auris Nasus Larynx 2017 Aug;44(4):375-380. Epub 2017 Mar 18 doi: 10.1016/j.anl.2017.02.004. PMID: 28325607

Recent clinical studies

Etiology

Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.
Tao Y, Sun XS, Pointreau Y, Le Tourneau C, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Calderon B, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Damstrup L, Crompton P, Ennaji A, Gollmer K, Nauwelaerts H, Bourhis J
Eur J Cancer 2023 Apr;183:24-37. Epub 2023 Jan 9 doi: 10.1016/j.ejca.2022.12.015. PMID: 36796234
Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study.
Sun JM, Shen L, Shah MA, Enzinger P, Adenis A, Doi T, Kojima T, Metges JP, Li Z, Kim SB, Cho BC, Mansoor W, Li SH, Sunpaweravong P, Maqueda MA, Goekkurt E, Hara H, Antunes L, Fountzilas C, Tsuji A, Oliden VC, Liu Q, Shah S, Bhagia P, Kato K; KEYNOTE-590 Investigators
Lancet 2021 Aug 28;398(10302):759-771. doi: 10.1016/S0140-6736(21)01234-4. PMID: 34454674
Neoadjuvant nivolumab for patients with resectable HPV-positive and HPV-negative squamous cell carcinomas of the head and neck in the CheckMate 358 trial.
Ferris RL, Spanos WC, Leidner R, Gonçalves A, Martens UM, Kyi C, Sharfman W, Chung CH, Devriese LA, Gauthier H, Chiosea SI, Vujanovic L, Taube JM, Stein JE, Li J, Li B, Chen T, Barrows A, Topalian SL
J Immunother Cancer 2021 Jun;9(6) doi: 10.1136/jitc-2021-002568. PMID: 34083421Free PMC Article
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer.
Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, Stewart JS, Jelic S, Betka J, Preiss JH, van den Weyngaert D, Awada A, Cupissol D, Kienzer HR, Rey A, Desaunois I, Bernier J, Lefebvre JL; EORTC 24971/TAX 323 Study Group
N Engl J Med 2007 Oct 25;357(17):1695-704. doi: 10.1056/NEJMoa071028. PMID: 17960012

Diagnosis

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Cutaneous Malignancies of the Head and Neck.
In GK, Thomas JS, Silk AW
Hematol Oncol Clin North Am 2021 Oct;35(5):991-1008. Epub 2021 Jul 16 doi: 10.1016/j.hoc.2021.05.008. PMID: 34281755
KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.
Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P
Future Oncol 2021 Apr;17(10):1143-1153. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0969. PMID: 33533655Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063

Therapy

Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study.
Sun JM, Shen L, Shah MA, Enzinger P, Adenis A, Doi T, Kojima T, Metges JP, Li Z, Kim SB, Cho BC, Mansoor W, Li SH, Sunpaweravong P, Maqueda MA, Goekkurt E, Hara H, Antunes L, Fountzilas C, Tsuji A, Oliden VC, Liu Q, Shah S, Bhagia P, Kato K; KEYNOTE-590 Investigators
Lancet 2021 Aug 28;398(10302):759-771. doi: 10.1016/S0140-6736(21)01234-4. PMID: 34454674
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.
Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, Piha-Paul SA, Doi T, Gao B, Chung HC, Lopez-Martin J, Bang YJ, Frommer RS, Shah M, Ghori R, Joe AK, Pruitt SK, Diaz LA Jr
J Clin Oncol 2020 Jan 1;38(1):1-10. Epub 2019 Nov 4 doi: 10.1200/JCO.19.02105. PMID: 31682550Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article

Prognosis

Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial.
Tao Y, Sun XS, Pointreau Y, Le Tourneau C, Sire C, Kaminsky MC, Coutte A, Alfonsi M, Calderon B, Boisselier P, Martin L, Miroir J, Ramee JF, Delord JP, Clatot F, Rolland F, Villa J, Magne N, Elicin O, Gherga E, Nguyen F, Lafond C, Bera G, Calugaru V, Geoffrois L, Chauffert B, Damstrup L, Crompton P, Ennaji A, Gollmer K, Nauwelaerts H, Bourhis J
Eur J Cancer 2023 Apr;183:24-37. Epub 2023 Jan 9 doi: 10.1016/j.ejca.2022.12.015. PMID: 36796234
Induction Chemotherapy for Advanced Oral Cavity Cancer.
de Oliveira TB, Marta GN, de Castro Junior G, Kowalski LP
Curr Oncol Rep 2021 Aug 27;23(11):129. doi: 10.1007/s11912-021-01119-6. PMID: 34453267
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Therapy of advanced squamous cell carcinoma of the skin.
Bejar C, Maubec E
Curr Treat Options Oncol 2014 Jun;15(2):302-20. doi: 10.1007/s11864-014-0280-x. PMID: 24643778

Clinical prediction guides

Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590): a randomised, placebo-controlled, phase 3 study.
Sun JM, Shen L, Shah MA, Enzinger P, Adenis A, Doi T, Kojima T, Metges JP, Li Z, Kim SB, Cho BC, Mansoor W, Li SH, Sunpaweravong P, Maqueda MA, Goekkurt E, Hara H, Antunes L, Fountzilas C, Tsuji A, Oliden VC, Liu Q, Shah S, Bhagia P, Kato K; KEYNOTE-590 Investigators
Lancet 2021 Aug 28;398(10302):759-771. doi: 10.1016/S0140-6736(21)01234-4. PMID: 34454674
Avelumab plus standard-of-care chemoradiotherapy versus chemoradiotherapy alone in patients with locally advanced squamous cell carcinoma of the head and neck: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial.
Lee NY, Ferris RL, Psyrri A, Haddad RI, Tahara M, Bourhis J, Harrington K, Chang PM, Lin JC, Razaq MA, Teixeira MM, Lövey J, Chamois J, Rueda A, Hu C, Dunn LA, Dvorkin MV, De Beukelaer S, Pavlov D, Thurm H, Cohen E
Lancet Oncol 2021 Apr;22(4):450-462. doi: 10.1016/S1470-2045(20)30737-3. PMID: 33794205
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article

Recent systematic reviews

p16(INK4a) status and survival benefit of EGFR inhibitors in head and neck squamous cell cancer: A systematic review and meta-analysis.
Su Y, Cui J, Xu D, Wang M, Xu T, Tian H, Han F
Crit Rev Oncol Hematol 2018 Apr;124:11-20. Epub 2018 Feb 7 doi: 10.1016/j.critrevonc.2018.02.006. PMID: 29548481
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Furness S, Glenny AM, Worthington HV, Pavitt S, Oliver R, Clarkson JE, Macluskey M, Chan KK, Conway DI
Cochrane Database Syst Rev 2011 Apr 13;(4):CD006386. doi: 10.1002/14651858.CD006386.pub3. PMID: 21491393
Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy.
Furness S, Glenny AM, Worthington HV, Pavitt S, Oliver R, Clarkson JE, Macluskey M, Chan KK, Conway DI; CSROC Expert Panel
Cochrane Database Syst Rev 2010 Sep 8;(9):CD006386. doi: 10.1002/14651858.CD006386.pub2. PMID: 20824847

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