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Unresectable Salivary Gland Carcinoma

MedGen UID:
1777899
•Concept ID:
C5420538
•
Neoplastic Process

Definition

Salivary gland carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Salivary Gland Carcinoma

Professional guidelines

PubMed

Management of Adenoid Cystic Carcinoma of the Head and Neck: Experience of the National Cancer Institute, Egypt.
Ayoub N, Nozhy A, Shawki A, Hassouna A, Ibraheem D, Elmahdy M, Amin A
Gulf J Oncolog 2022 May;1(39):63-69. PMID: 35695348
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Management of malignant tumors of the salivary glands.
Spiro RH
Oncology (Williston Park) 1998 May;12(5):671-80; discussion 683. PMID: 9597678

Recent clinical studies

Etiology

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Minor salivary gland carcinoma: a review of 35 cases.
Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MCh, Erovic BM
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2717-26. Epub 2015 Oct 23 doi: 10.1007/s00405-015-3805-4. PMID: 26498950
A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network).
Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, Ali AM, Testelin S, Reyt E, Janot F, Thariat J
Crit Rev Oncol Hematol 2014 Aug;91(2):142-58. Epub 2014 Feb 16 doi: 10.1016/j.critrevonc.2014.02.002. PMID: 24636481

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Adenoid Cystic Carcinoma.
Castelnuovo P, Turri-Zanoni M
Adv Otorhinolaryngol 2020;84:197-209. Epub 2020 Jul 30 doi: 10.1159/000457939. PMID: 32731238
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Therapy

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network).
Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, Ali AM, Testelin S, Reyt E, Janot F, Thariat J
Crit Rev Oncol Hematol 2014 Aug;91(2):142-58. Epub 2014 Feb 16 doi: 10.1016/j.critrevonc.2014.02.002. PMID: 24636481
Malignant salivary gland tumours: can fast neutron therapy results point the way to carbon ion therapy?
Stannard C, Vernimmen F, Carrara H, Jones D, Fredericks S, Hille J, de Kock E
Radiother Oncol 2013 Nov;109(2):262-8. Epub 2013 Sep 14 doi: 10.1016/j.radonc.2013.08.013. PMID: 24044797
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Minor salivary gland carcinoma: a review of 35 cases.
Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MCh, Erovic BM
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2717-26. Epub 2015 Oct 23 doi: 10.1007/s00405-015-3805-4. PMID: 26498950
A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? On behalf of the REFCOR (French rare head and neck cancer network).
Cerda T, Sun XS, Vignot S, Marcy PY, Baujat B, Baglin AC, Ali AM, Testelin S, Reyt E, Janot F, Thariat J
Crit Rev Oncol Hematol 2014 Aug;91(2):142-58. Epub 2014 Feb 16 doi: 10.1016/j.critrevonc.2014.02.002. PMID: 24636481
Management of malignant tumors of the salivary glands.
Spiro RH
Oncology (Williston Park) 1998 May;12(5):671-80; discussion 683. PMID: 9597678

Clinical prediction guides

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma.
Chen Z, Ni W, Li JL, Lin S, Zhou X, Sun Y, Li JW, Leon ME, Hurtado MD, Zolotukhin S, Liu C, Lu J, Griffin JD, Kaye FJ, Wu L
JCI Insight 2021 Apr 8;6(7) doi: 10.1172/jci.insight.139497. PMID: 33830080Free PMC Article
Pretreatment Primary Tumor SUVmax on 18F-FDG PET/CT Images Predicts Outcomes in Patients With Salivary Gland Carcinoma Treated With Definitive Intensity-Modulated Radiation Therapy.
Hsieh CE, Ho KC, Hsieh CH, Yen TC, Liao CT, Wang HM, Lin CY
Clin Nucl Med 2017 Sep;42(9):655-662. doi: 10.1097/RLU.0000000000001740. PMID: 28650891
Phosphorylated epidermal growth factor receptor expression and KRAS mutation status in salivary gland carcinomas.
Schneider T, Strehl A, Linz C, Brands R, Hartmann S, Beckford F, Rosenwald A, Kübler AC, Müller-Richter UD
Clin Oral Investig 2016 Apr;20(3):541-51. Epub 2015 Aug 6 doi: 10.1007/s00784-015-1541-1. PMID: 26245271
Fluorouracil, doxorubicin, cyclophosphamide, and cisplatin combination chemotherapy in advanced or recurrent salivary gland carcinoma.
Dimery IW, Legha SS, Shirinian M, Hong WK
J Clin Oncol 1990 Jun;8(6):1056-62. doi: 10.1200/JCO.1990.8.6.1056. PMID: 2112183

Recent systematic reviews

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390

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