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Unresectable Salivary Gland Carcinoma

MedGen UID:
1777899
•Concept ID:
C5420538
•
Neoplastic Process

Definition

Salivary gland carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Salivary Gland Carcinoma

Professional guidelines

PubMed

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Management of malignant tumors of the salivary glands.
Spiro RH
Oncology (Williston Park) 1998 May;12(5):671-80; discussion 683. PMID: 9597678

Recent clinical studies

Etiology

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Minor salivary gland carcinoma: a review of 35 cases.
Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MCh, Erovic BM
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2717-26. Epub 2015 Oct 23 doi: 10.1007/s00405-015-3805-4. PMID: 26498950

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Adenoid Cystic Carcinoma.
Castelnuovo P, Turri-Zanoni M
Adv Otorhinolaryngol 2020;84:197-209. Epub 2020 Jul 30 doi: 10.1159/000457939. PMID: 32731238
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Therapy

Apalutamide and Goserelin for Androgen Receptor-Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU.
Honma Y, Monden N, Yamazaki K, Kano S, Satake H, Kadowaki S, Utsumi Y, Nakatogawa T, Takano R, Fujii K, Koroki Y, Aoyama J, Ouchi S, Ogawa T, McCarthy S, Brookman-May SD, Mundle S, Li J, Thaper D, Nagao T, Tada Y
Clin Cancer Res 2024 Aug 15;30(16):3416-3427. doi: 10.1158/1078-0432.CCR-24-0455. PMID: 38940667
Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Efficacy and toxicity of sorafenib in patients with adenoid cystic carcinoma of the head and neck: a case series of five patients.
Couvreur K, Celine J, Marlies B, Randal D, Philippe D, Frederic D, Sylvie R
Acta Clin Belg 2020 Oct;75(5):362-369. Epub 2019 Jun 23 doi: 10.1080/17843286.2019.1633490. PMID: 31232197
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Major and minor salivary gland tumours.
Gatta G, Guzzo M, Locati LD, McGurk M, Prott FJ
Crit Rev Oncol Hematol 2020 Aug;152:102959. Epub 2020 May 18 doi: 10.1016/j.critrevonc.2020.102959. PMID: 32485526
Minor salivary gland carcinoma: a review of 35 cases.
Haymerle G, Schneider S, Harris L, Häupl T, Schopper C, Pammer J, Grasl MCh, Erovic BM
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2717-26. Epub 2015 Oct 23 doi: 10.1007/s00405-015-3805-4. PMID: 26498950
Management of malignant tumors of the salivary glands.
Spiro RH
Oncology (Williston Park) 1998 May;12(5):671-80; discussion 683. PMID: 9597678

Clinical prediction guides

Apalutamide and Goserelin for Androgen Receptor-Positive Salivary Gland Carcinoma: A Phase II Nonrandomized Clinical Trial, YATAGARASU.
Honma Y, Monden N, Yamazaki K, Kano S, Satake H, Kadowaki S, Utsumi Y, Nakatogawa T, Takano R, Fujii K, Koroki Y, Aoyama J, Ouchi S, Ogawa T, McCarthy S, Brookman-May SD, Mundle S, Li J, Thaper D, Nagao T, Tada Y
Clin Cancer Res 2024 Aug 15;30(16):3416-3427. doi: 10.1158/1078-0432.CCR-24-0455. PMID: 38940667
Targeting human EGFR 2 (HER2) in salivary gland carcinoma.
Wotman M, El-Naggar A, Ferrarotto R
Expert Rev Anticancer Ther 2023 Jun;23(6):573-582. Epub 2023 May 16 doi: 10.1080/14737140.2023.2208350. PMID: 37114470
Trophoblast Cell Surface Antigen 2 (Trop-2) Protein is Highly Expressed in Salivary Gland Carcinomas and Represents a Potential Therapeutic Target.
Wolber P, Nachtsheim L, Hoffmann F, Klußmann JP, Meyer M, von Eggeling F, Guntinas-Lichius O, Quaas A, Arolt C
Head Neck Pathol 2021 Dec;15(4):1147-1155. Epub 2021 Apr 22 doi: 10.1007/s12105-021-01325-5. PMID: 33886073Free PMC Article
Phosphorylated epidermal growth factor receptor expression and KRAS mutation status in salivary gland carcinomas.
Schneider T, Strehl A, Linz C, Brands R, Hartmann S, Beckford F, Rosenwald A, Kübler AC, Müller-Richter UD
Clin Oral Investig 2016 Apr;20(3):541-51. Epub 2015 Aug 6 doi: 10.1007/s00784-015-1541-1. PMID: 26245271
Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expressions in salivary duct carcinoma.
Masubuchi T, Tada Y, Maruya S, Osamura Y, Kamata SE, Miura K, Fushimi C, Takahashi H, Kawakita D, Kishimoto S, Nagao T
Int J Clin Oncol 2015 Feb;20(1):35-44. Epub 2014 Feb 20 doi: 10.1007/s10147-014-0674-6. PMID: 24553861

Recent systematic reviews

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390

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