U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nasopharyngeal Pituitary Neuroendocrine Tumor

MedGen UID:
1777923
•Concept ID:
C5420164
•
Neoplastic Process
Synonyms: Nasopharyngeal PitNET/Adenoma; Nasopharyngeal Pituitary Gland Adenoma; Nasopharyngeal Pituitary Neuroendocrine Tumor/Adenoma

Definition

An ectopic pituitary neuroendocrine tumor that arises from the nasopharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Pituitary Neuroendocrine Tumor

Professional guidelines

PubMed

Ectopic pituitary adenomas: clinical features, diagnostic challenges and management.
Zhu J, Wang Z, Zhang Y, Li X, Liu J, Deng K, Lu L, Pan H, Wang R, Yao Y, Zhu H
Pituitary 2020 Dec;23(6):648-664. doi: 10.1007/s11102-020-01071-x. PMID: 32757141
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
The Differential Diagnosis of Sinonasal/Nasopharyngeal Neuroendocrine/Neuroectodermally Derived Tumors.
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022

Recent clinical studies

Etiology

Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Long-Term Effect of Cranial Radiotherapy on Pituitary-Hypothalamus Area in Childhood Acute Lymphoblastic Leukemia Survivors.
Follin C, Erfurth EM
Curr Treat Options Oncol 2016 Sep;17(9):50. doi: 10.1007/s11864-016-0426-0. PMID: 27476159Free PMC Article
Tumors of the anterior skull base.
Ivan ME, Han SJ, Aghi MK
Expert Rev Neurother 2014 Apr;14(4):425-38. Epub 2014 Feb 25 doi: 10.1586/14737175.2014.892830. PMID: 24564556
Radiotherapy-induced hypopituitarism: a review.
Sathyapalan T, Dixit S
Expert Rev Anticancer Ther 2012 May;12(5):669-83. doi: 10.1586/era.12.27. PMID: 22594901
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Diagnosis

Variability in Clinical Presentation and Pathologic Implications of Ectopic Pituitary Tumors: Critical Review of Literature.
Shuman W, Loewenstern J, Pai A, Bederson J, Shrivastava R
World Neurosurg 2019 Feb;122:397-403. Epub 2018 Nov 4 doi: 10.1016/j.wneu.2018.10.200. PMID: 30404064
The Differential Diagnosis of Sinonasal/Nasopharyngeal Neuroendocrine/Neuroectodermally Derived Tumors.
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022
Tumors of the anterior skull base.
Ivan ME, Han SJ, Aghi MK
Expert Rev Neurother 2014 Apr;14(4):425-38. Epub 2014 Feb 25 doi: 10.1586/14737175.2014.892830. PMID: 24564556
Radiotherapy-induced hypopituitarism: a review.
Sathyapalan T, Dixit S
Expert Rev Anticancer Ther 2012 May;12(5):669-83. doi: 10.1586/era.12.27. PMID: 22594901
Hypopituitarism after cranial irradiation.
Darzy KH, Shalet SM
J Endocrinol Invest 2005;28(5 Suppl):78-87. PMID: 16114281

Therapy

Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Long-Term Effect of Cranial Radiotherapy on Pituitary-Hypothalamus Area in Childhood Acute Lymphoblastic Leukemia Survivors.
Follin C, Erfurth EM
Curr Treat Options Oncol 2016 Sep;17(9):50. doi: 10.1007/s11864-016-0426-0. PMID: 27476159Free PMC Article
Radiotherapy-induced hypopituitarism: a review.
Sathyapalan T, Dixit S
Expert Rev Anticancer Ther 2012 May;12(5):669-83. doi: 10.1586/era.12.27. PMID: 22594901
Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis.
Appelman-Dijkstra NM, Kokshoorn NE, Dekkers OM, Neelis KJ, Biermasz NR, Romijn JA, Smit JW, Pereira AM
J Clin Endocrinol Metab 2011 Aug;96(8):2330-40. Epub 2011 May 25 doi: 10.1210/jc.2011-0306. PMID: 21613351Free PMC Article
Radiation-induced growth hormone deficiency.
Darzy KH, Shalet SM
Horm Res 2003;59 Suppl 1:1-11. doi: 10.1159/000067834. PMID: 12566714

Prognosis

Early post-treatment (18)F-FDG PET/CT for predicting radiation-induced hypothyroidism in head and neck cancer.
Lu HH, Chiu NT, Tsai MH
Cancer Imaging 2022 Oct 10;22(1):59. doi: 10.1186/s40644-022-00494-y. PMID: 36217182Free PMC Article
Nasopharyngeal B-cell lymphoma with pan-hypopituitarism and oculomotor nerve palsy: a case report and review of the literature.
Zahedi M, Hizomi Arani R, Tohidi M, Haghighi S, Mehrpour M, Hadaegh F
BMC Endocr Disord 2020 Nov 3;20(1):163. doi: 10.1186/s12902-020-00644-y. PMID: 33143716Free PMC Article
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Mohamed Ali A, Mathis T, Bensadoun RJ, Thariat J
Bull Cancer 2019 Dec;106(12):1160-1176. Epub 2019 Nov 19 doi: 10.1016/j.bulcan.2019.09.008. PMID: 31757405
Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery.
Ivan ME, Iorgulescu JB, El-Sayed I, McDermott MW, Parsa AT, Pletcher SD, Jahangiri A, Wagner J, Aghi MK
J Clin Neurosci 2015 Jan;22(1):48-54. Epub 2014 Nov 22 doi: 10.1016/j.jocn.2014.08.009. PMID: 25439754
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920

Clinical prediction guides

Early post-treatment (18)F-FDG PET/CT for predicting radiation-induced hypothyroidism in head and neck cancer.
Lu HH, Chiu NT, Tsai MH
Cancer Imaging 2022 Oct 10;22(1):59. doi: 10.1186/s40644-022-00494-y. PMID: 36217182Free PMC Article
Risk factors for postoperative cerebrospinal fluid leak and meningitis after expanded endoscopic endonasal surgery.
Ivan ME, Iorgulescu JB, El-Sayed I, McDermott MW, Parsa AT, Pletcher SD, Jahangiri A, Wagner J, Aghi MK
J Clin Neurosci 2015 Jan;22(1):48-54. Epub 2014 Nov 22 doi: 10.1016/j.jocn.2014.08.009. PMID: 25439754
Pituitary dysfunction in adult patients after cranial irradiation for head and nasopharyngeal tumours.
Appelman-Dijkstra NM, Malgo F, Neelis KJ, Coremans I, Biermasz NR, Pereira AM
Radiother Oncol 2014 Oct;113(1):102-7. Epub 2014 Sep 15 doi: 10.1016/j.radonc.2014.08.018. PMID: 25236713
Infrasellar craniopharyngioma.
Yu X, Liu R, Wang Y, Wang H, Zhao H, Wu Z
Clin Neurol Neurosurg 2012 Feb;114(2):112-9. Epub 2011 Oct 21 doi: 10.1016/j.clineuro.2011.09.010. PMID: 22018920
Immunohistochemical survey of migration of human anterior pituitary cells in developmental, pathological, and clinical aspects: a review.
Hori A, Schmidt D, Kuebber S
Microsc Res Tech 1999 Jul 1;46(1):59-68. doi: 10.1002/(SICI)1097-0029(19990701)46:1<59::AID-JEMT6>3.0.CO;2-S. PMID: 10402273

Recent systematic reviews

Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review.
Zhou Z, Zuo F, Chen X, Zhao Q, Luo M, Jiang X, Duan Y
BMC Neurol 2021 Oct 27;21(1):417. doi: 10.1186/s12883-021-02440-0. PMID: 34706659Free PMC Article
Are hypothalamic- pituitary (HP) axis deficiencies after whole brain radiotherapy (WBRT) of relevance for adult cancer patients? - a systematic review of the literature.
Mehta P, Fahlbusch FB, Rades D, Schmid SM, Gebauer J, Janssen S
BMC Cancer 2019 Dec 12;19(1):1213. doi: 10.1186/s12885-019-6431-5. PMID: 31830931Free PMC Article
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature.
Seltzer J, Lucas J, Commins D, Lerner O, Lerner A, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E10. doi: 10.3171/2014.10.FOCUS14685. PMID: 25639312
Pituitary dysfunction in adult patients after cranial radiotherapy: systematic review and meta-analysis.
Appelman-Dijkstra NM, Kokshoorn NE, Dekkers OM, Neelis KJ, Biermasz NR, Romijn JA, Smit JW, Pereira AM
J Clin Endocrinol Metab 2011 Aug;96(8):2330-40. Epub 2011 May 25 doi: 10.1210/jc.2011-0306. PMID: 21613351Free PMC Article
Paediatric nasopharyngeal rhabdomyosarcoma: A case series and literature review.
Healy JN, Borg MF
J Med Imaging Radiat Oncol 2010 Aug;54(4):388-94. doi: 10.1111/j.1754-9485.2010.02187.x. PMID: 20718921

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...