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Refractory Mature T-Cell and NK-Cell Neoplasm

MedGen UID:
1777946
•Concept ID:
C5420196
•
Neoplastic Process

Definition

Mature T-cell and NK-cell neoplasm that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Mature T-Cell and NK-Cell Neoplasm

Professional guidelines

PubMed

Clinical Practice Recommendations on Indication and Timing of Hematopoietic Cell Transplantation in Mature T Cell and NK/T Cell Lymphomas: An International Collaborative Effort on Behalf of the Guidelines Committee of the American Society for Blood and Marrow Transplantation.
Kharfan-Dabaja MA, Kumar A, Ayala E, Hamadani M, Reimer P, Gisselbrecht C, d'Amore F, Jantunen E, Ishida T, Bazarbachi A, Foss F, Advani R, Fenske TS, Lazarus HM, Friedberg JW, Aljurf M, Sokol L, Tobinai K, Tse E, Burns LJ, Chavez JC, Reddy NM, Suzuki R, Ahmed S, Nademanee A, Mohty M, Gopal AK, Fanale MA, Pro B, Moskowitz AJ, Sureda A, Perales MA, Carpenter PA, Savani BN
Biol Blood Marrow Transplant 2017 Nov;23(11):1826-1838. Epub 2017 Aug 7 doi: 10.1016/j.bbmt.2017.07.027. PMID: 28797780
Treatment of peripheral T-cell lymphoma: are we data driven or driving the data?
Lunning MA, Horwitz S
Curr Treat Options Oncol 2013 Jun;14(2):212-23. doi: 10.1007/s11864-013-0232-x. PMID: 23568456Free PMC Article
Targeted treatment and new agents in peripheral T-cell lymphoma.
Zain JM, O'Connor O
Int J Hematol 2010 Jul;92(1):33-44. Epub 2010 Jun 10 doi: 10.1007/s12185-010-0614-9. PMID: 20535594

Recent clinical studies

Etiology

Hematopoietic Stem Cell Transplantation in T Cell and Natural Killer Cell Lymphomas: Update on Recent Advances.
Boo YL, Koh LP
Transplant Cell Ther 2021 Jul;27(7):571-588. Epub 2021 Apr 20 doi: 10.1016/j.jtct.2021.04.002. PMID: 33857661
New directions in treating peripheral T-cell lymphomas (PTCL): leveraging epigenetic modifiers alone and in combination.
Ma H, O'Connor OA, Marchi E
Expert Rev Hematol 2019 Mar;12(3):137-146. Epub 2019 Feb 27 doi: 10.1080/17474086.2019.1583102. PMID: 30782038
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas.
Schmitz N, Lenz G, Stelljes M
Blood 2018 Jul 19;132(3):245-253. Epub 2018 Apr 26 doi: 10.1182/blood-2018-01-791335. PMID: 29699989
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318

Diagnosis

Innovative Anti-CD38 and Anti-BCMA Targeted Therapies in Multiple Myeloma: Mechanisms of Action and Resistance.
De Novellis D, Fontana R, Giudice V, Serio B, Selleri C
Int J Mol Sci 2022 Dec 30;24(1) doi: 10.3390/ijms24010645. PMID: 36614086Free PMC Article
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas.
Schmitz N, Lenz G, Stelljes M
Blood 2018 Jul 19;132(3):245-253. Epub 2018 Apr 26 doi: 10.1182/blood-2018-01-791335. PMID: 29699989
Large granular lymphocyte leukemia.
Sokol L, Loughran TP Jr
Oncologist 2006 Mar;11(3):263-73. doi: 10.1634/theoncologist.11-3-263. PMID: 16549811
T gamma lymphocytosis and T cell chronic leukemias.
Berliner N
Hematol Oncol Clin North Am 1990 Apr;4(2):473-87. PMID: 2182603

Therapy

Long-term outcomes following CAR T cell therapy: what we know so far.
Cappell KM, Kochenderfer JN
Nat Rev Clin Oncol 2023 Jun;20(6):359-371. Epub 2023 Apr 13 doi: 10.1038/s41571-023-00754-1. PMID: 37055515Free PMC Article
Innovative Anti-CD38 and Anti-BCMA Targeted Therapies in Multiple Myeloma: Mechanisms of Action and Resistance.
De Novellis D, Fontana R, Giudice V, Serio B, Selleri C
Int J Mol Sci 2022 Dec 30;24(1) doi: 10.3390/ijms24010645. PMID: 36614086Free PMC Article
PD-1 Inhibitor Combined With Radiotherapy and GM-CSF (PRaG) in Patients With Metastatic Solid Tumors: An Open-Label Phase II Study.
Kong Y, Zhao X, Xu M, Pan J, Ma Y, Zou L, Peng Q, Zhang J, Su C, Xu Z, Zhou W, Peng Y, Yang J, Zhou C, Li Y, Guo Q, Chen G, Wu H, Xing P, Zhang L
Front Immunol 2022;13:952066. Epub 2022 Jul 8 doi: 10.3389/fimmu.2022.952066. PMID: 35874780Free PMC Article
Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma.
Raje N, Berdeja J, Lin Y, Siegel D, Jagannath S, Madduri D, Liedtke M, Rosenblatt J, Maus MV, Turka A, Lam LP, Morgan RA, Friedman K, Massaro M, Wang J, Russotti G, Yang Z, Campbell T, Hege K, Petrocca F, Quigley MT, Munshi N, Kochenderfer JN
N Engl J Med 2019 May 2;380(18):1726-1737. doi: 10.1056/NEJMoa1817226. PMID: 31042825Free PMC Article
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223

Prognosis

Long-term outcomes following CAR T cell therapy: what we know so far.
Cappell KM, Kochenderfer JN
Nat Rev Clin Oncol 2023 Jun;20(6):359-371. Epub 2023 Apr 13 doi: 10.1038/s41571-023-00754-1. PMID: 37055515Free PMC Article
PD-1 Inhibitor Combined With Radiotherapy and GM-CSF (PRaG) in Patients With Metastatic Solid Tumors: An Open-Label Phase II Study.
Kong Y, Zhao X, Xu M, Pan J, Ma Y, Zou L, Peng Q, Zhang J, Su C, Xu Z, Zhou W, Peng Y, Yang J, Zhou C, Li Y, Guo Q, Chen G, Wu H, Xing P, Zhang L
Front Immunol 2022;13:952066. Epub 2022 Jul 8 doi: 10.3389/fimmu.2022.952066. PMID: 35874780Free PMC Article
Hematopoietic Stem Cell Transplantation in T Cell and Natural Killer Cell Lymphomas: Update on Recent Advances.
Boo YL, Koh LP
Transplant Cell Ther 2021 Jul;27(7):571-588. Epub 2021 Apr 20 doi: 10.1016/j.jtct.2021.04.002. PMID: 33857661
Allogeneic hematopoietic stem cell transplantation for T-cell lymphomas.
Schmitz N, Lenz G, Stelljes M
Blood 2018 Jul 19;132(3):245-253. Epub 2018 Apr 26 doi: 10.1182/blood-2018-01-791335. PMID: 29699989
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318

Clinical prediction guides

Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study.
Bachy E, Savage KJ, Huang H, Kwong YL, Gritti G, Zhang Q, Liberati AM, Cao J, Yang H, Hao S, Hu J, Zhou K, Petrini M, Russo F, Zhang H, Sang W, Ji J, Ferreri AJM, Damaj GL, Liu H, Zhang W, Ke X, Ghiggi C, Huang S, Li X, Yao H, Paik J, Novotny W, Zhou W, Zhu H, Zinzani PL
Blood Adv 2023 Aug 22;7(16):4435-4447. doi: 10.1182/bloodadvances.2022009575. PMID: 37276067Free PMC Article
Long-term outcomes following CAR T cell therapy: what we know so far.
Cappell KM, Kochenderfer JN
Nat Rev Clin Oncol 2023 Jun;20(6):359-371. Epub 2023 Apr 13 doi: 10.1038/s41571-023-00754-1. PMID: 37055515Free PMC Article
High-dose extended-field radiotherapy plus chemotherapy improved survival in extranodal NK/T-cell lymphoma in a real-life setting: results from the multicenter T-Cell Brazil Project.
de Pádua Covas Lage LA, Machado PPF, Reichert CO, Miranda E, Culler HF, da Siqueira SAC, de Oliveira Costa R, Miyashiro DR, Sanches JA, Rocha V, Chiattone CS, Pereira J
Sci Rep 2022 Nov 29;12(1):20557. doi: 10.1038/s41598-022-25034-3. PMID: 36446856Free PMC Article
Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia.
Duault C, Kumar A, Taghi Khani A, Lee SJ, Yang L, Huang M, Hurtz C, Manning B, Ghoda L, McDonald T, Lacayo NJ, Sakamoto KM, Carroll M, Tasian SK, Marcucci G, Yu J, Caligiuri MA, Maecker HT, Swaminathan S
Blood 2021 Oct 21;138(16):1465-1480. doi: 10.1182/blood.2020009871. PMID: 34077953Free PMC Article
New directions in treating peripheral T-cell lymphomas (PTCL): leveraging epigenetic modifiers alone and in combination.
Ma H, O'Connor OA, Marchi E
Expert Rev Hematol 2019 Mar;12(3):137-146. Epub 2019 Feb 27 doi: 10.1080/17474086.2019.1583102. PMID: 30782038

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