U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal glomerular mesangial matrix morphology

MedGen UID:
1778151
Concept ID:
C5539441
Anatomical Abnormality
HPO: HP:0033232

Definition

Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix. [from HPO]

Professional guidelines

PubMed

Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA
Curr Opin Nephrol Hypertens 2004 Jul;13(4):417-22. doi: 10.1097/01.mnh.0000133974.24935.fe. PMID: 15199292

Recent clinical studies

Etiology

Wang Z, Huang W, Li H, Tang L, Sun H, Liu Q, Zhang L
Ren Fail 2018 Nov;40(1):175-182. doi: 10.1080/0886022X.2018.1450763. PMID: 29569980Free PMC Article
Avila-Casado C, Fortoul TI, Chugh SS
Contrib Nephrol 2011;169:270-285. Epub 2011 Jan 20 doi: 10.1159/000320212. PMID: 21252526
Danilewicz M, Wagrowska-Danilewicz M
Folia Histochem Cytobiol 2010 Jan 1;48(1):63-7. doi: 10.2478/v10042-008-0086-4. PMID: 20529817
Ferrario F, Rastaldi MP, Napodano P
Ann Med Interne (Paris) 1999 Feb;150(2):108-16. PMID: 10392259
Pröls F, Hartner A, Schöcklmann HO, Sterzel RB
Exp Nephrol 1999 Mar-Apr;7(2):137-46. doi: 10.1159/000020594. PMID: 10213867

Diagnosis

Cook HT, Pickering MC
Nat Rev Nephrol 2015 Jan;11(1):14-22. Epub 2014 Dec 2 doi: 10.1038/nrneph.2014.217. PMID: 25447133
Cohen AH
Adv Chronic Kidney Dis 2012 Mar;19(2):101-6. doi: 10.1053/j.ackd.2012.02.017. PMID: 22449347
Najafian B, Alpers CE, Fogo AB
Contrib Nephrol 2011;170:36-47. Epub 2011 Jun 9 doi: 10.1159/000324942. PMID: 21659756
Hisakawa N, Yasuoka N, Nishiya K, Kumon Y, Okamoto K, Itoh H, Hashimoto K, Moriki T
Am J Nephrol 1998;18(2):134-41. doi: 10.1159/000013322. PMID: 9569956
Cameron JS, Glasgow EF, Ogg CS, White RH
Br Med J 1970 Oct 3;4(5726):7-14. doi: 10.1136/bmj.4.5726.7. PMID: 4097129Free PMC Article

Therapy

Lu Z, Zhong Y, Liu W, Xiang L, Deng Y
J Diabetes Res 2019;2019:2697672. Epub 2019 Aug 25 doi: 10.1155/2019/2697672. PMID: 31534972Free PMC Article
Wang Z, Huang W, Li H, Tang L, Sun H, Liu Q, Zhang L
Ren Fail 2018 Nov;40(1):175-182. doi: 10.1080/0886022X.2018.1450763. PMID: 29569980Free PMC Article
Chen S, Hong SW, Iglesias-de la Cruz MC, Isono M, Casaretto A, Ziyadeh FN
Ren Fail 2001 May-Jul;23(3-4):471-81. doi: 10.1081/jdi-100104730. PMID: 11499562
Schwartz MM, Lewis EJ, Leonard-Martin T, Lewis JB, Batlle D
Nephrol Dial Transplant 1998 Oct;13(10):2547-52. doi: 10.1093/ndt/13.10.2547. PMID: 9794557
Cameron JS, Glasgow EF, Ogg CS, White RH
Br Med J 1970 Oct 3;4(5726):7-14. doi: 10.1136/bmj.4.5726.7. PMID: 4097129Free PMC Article

Prognosis

Cohen AH
Adv Chronic Kidney Dis 2012 Mar;19(2):101-6. doi: 10.1053/j.ackd.2012.02.017. PMID: 22449347
Najafian B, Alpers CE, Fogo AB
Contrib Nephrol 2011;170:36-47. Epub 2011 Jun 9 doi: 10.1159/000324942. PMID: 21659756
Lai AS, Lai KN
Curr Mol Med 2005 Aug;5(5):475-87. doi: 10.2174/1566524054553450. PMID: 16101476
Hisakawa N, Yasuoka N, Nishiya K, Kumon Y, Okamoto K, Itoh H, Hashimoto K, Moriki T
Am J Nephrol 1998;18(2):134-41. doi: 10.1159/000013322. PMID: 9569956
Cameron JS, Glasgow EF, Ogg CS, White RH
Br Med J 1970 Oct 3;4(5726):7-14. doi: 10.1136/bmj.4.5726.7. PMID: 4097129Free PMC Article

Clinical prediction guides

Lai AS, Lai KN
Curr Mol Med 2005 Aug;5(5):475-87. doi: 10.2174/1566524054553450. PMID: 16101476
Urushihara M, Kagami S, Kuhara T, Tamaki T, Kuroda Y
Nephrol Dial Transplant 2002 Jul;17(7):1189-96. doi: 10.1093/ndt/17.7.1189. PMID: 12105240
Kamanna VS
Histol Histopathol 2002 Apr;17(2):497-505. doi: 10.14670/HH-17.497. PMID: 11962755
Schleicher E, Kolm V, Ceol M, Nerlich A
Kidney Blood Press Res 1996;19(5):305-15. doi: 10.1159/000174091. PMID: 8956243
Olson JL, Heptinstall RH
Lab Invest 1988 Nov;59(5):564-78. PMID: 3054312

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...