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Increased circulating prealbumin concentration

MedGen UID:
1778311
•Concept ID:
C5539604
•
Finding
HPO: HP:0033451

Definition

An elevation above the normal concentration of prealbumin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating prealbumin concentration

Recent clinical studies

Etiology

Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is a practical aid to nutritional assessment in hospital in-patients.
Player EL, Morris P, Thomas T, Chan WY, Vyas R, Dutton J, Tang J, Alexandre L, Forbes A
Clin Nutr 2019 Aug;38(4):1700-1706. Epub 2018 Aug 17 doi: 10.1016/j.clnu.2018.08.003. PMID: 30170780
Downsizing of lean body mass is a key determinant of Alzheimer's disease.
Ingenbleek Y, Bernstein LH
J Alzheimers Dis 2015;44(3):745-54. doi: 10.3233/JAD-141950. PMID: 25380591
Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women.
Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
Insulin resistance is unrelated to circulating retinol binding protein and protein C inhibitor.
Promintzer M, Krebs M, Todoric J, Luger A, Bischof MG, Nowotny P, Wagner O, Esterbauer H, Anderwald C
J Clin Endocrinol Metab 2007 Nov;92(11):4306-12. Epub 2007 Aug 28 doi: 10.1210/jc.2006-2522. PMID: 17726077
In vivo modulation of coagulation and fibrinolysis by recombinant glycosylated human interleukin-6 in baboons.
Mestries JC, Kruithof EK, Gascon MP, Herodin F, Agay D, Ythier A
Eur Cytokine Netw 1994 May-Jun;5(3):275-81. PMID: 7948765

Diagnosis

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown.
Yárnoz-Esquíroz P, Chopitea A, Olazarán L, Aguas-Ayesa M, Silva C, Vilalta-Lacarra A, Escalada J, Gil-Bazo I, Frühbeck G, Gómez-Ambrosi J
Nutrients 2022 Jul 2;14(13) doi: 10.3390/nu14132754. PMID: 35807934Free PMC Article
Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is a practical aid to nutritional assessment in hospital in-patients.
Player EL, Morris P, Thomas T, Chan WY, Vyas R, Dutton J, Tang J, Alexandre L, Forbes A
Clin Nutr 2019 Aug;38(4):1700-1706. Epub 2018 Aug 17 doi: 10.1016/j.clnu.2018.08.003. PMID: 30170780
Downsizing of lean body mass is a key determinant of Alzheimer's disease.
Ingenbleek Y, Bernstein LH
J Alzheimers Dis 2015;44(3):745-54. doi: 10.3233/JAD-141950. PMID: 25380591
Increased serum concentration of circulating soluble receptor for interleukin-2 and its effect as a prognostic indicator in cachectic patients with gastric and colorectal cancer.
Shibata M, Takekawa M
Oncology 1999;56(1):54-8. doi: 10.1159/000011930. PMID: 9885378
Nutritional regulation of the insulin-like growth factors.
Thissen JP, Ketelslegers JM, Underwood LE
Endocr Rev 1994 Feb;15(1):80-101. doi: 10.1210/edrv-15-1-80. PMID: 8156941

Therapy

Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is a practical aid to nutritional assessment in hospital in-patients.
Player EL, Morris P, Thomas T, Chan WY, Vyas R, Dutton J, Tang J, Alexandre L, Forbes A
Clin Nutr 2019 Aug;38(4):1700-1706. Epub 2018 Aug 17 doi: 10.1016/j.clnu.2018.08.003. PMID: 30170780
Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women.
Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC
J Clin Endocrinol Metab 2008 Jun;93(6):2263-8. Epub 2008 Mar 11 doi: 10.1210/jc.2007-2028. PMID: 18334592
The effect of total starvation and very low energy diet in lean men on kinetics of whole body protein and five hepatic secretory proteins.
Afolabi PR, Jahoor F, Jackson AA, Stubbs J, Johnstone AM, Faber P, Lobley G, Gibney E, Elia M
Am J Physiol Endocrinol Metab 2007 Dec;293(6):E1580-9. Epub 2007 Sep 18 doi: 10.1152/ajpendo.00169.2007. PMID: 17878226
Differential responses of IGF-I molecular complexes to military operational field training.
Nindl BC, Castellani JW, Young AJ, Patton JF, Khosravi MJ, Diamandi A, Montain SJ
J Appl Physiol (1985) 2003 Sep;95(3):1083-9. doi: 10.1152/japplphysiol.01148.2002. PMID: 12909598
Comparison of modified amino acids and standard amino acids in parenteral nutrition support of thermally injured patients.
Brown RO, Buonpane EA, Vehe KL, Hickerson WL, Luther RW
Crit Care Med 1990 Oct;18(10):1096-101. doi: 10.1097/00003246-199010000-00009. PMID: 2119935

Prognosis

Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is a practical aid to nutritional assessment in hospital in-patients.
Player EL, Morris P, Thomas T, Chan WY, Vyas R, Dutton J, Tang J, Alexandre L, Forbes A
Clin Nutr 2019 Aug;38(4):1700-1706. Epub 2018 Aug 17 doi: 10.1016/j.clnu.2018.08.003. PMID: 30170780
Downsizing of lean body mass is a key determinant of Alzheimer's disease.
Ingenbleek Y, Bernstein LH
J Alzheimers Dis 2015;44(3):745-54. doi: 10.3233/JAD-141950. PMID: 25380591
Persistent organic pollutants and transthyretin-bound thyroxin in plasma of Inuit women of childbearing age.
Audet-Delage Y, Ouellet N, Dallaire R, Dewailly E, Ayotte P
Environ Sci Technol 2013 Nov 19;47(22):13086-92. Epub 2013 Nov 11 doi: 10.1021/es4027634. PMID: 24160776
Simultaneous measurements of serum insulin-like growth factor-I and leptin reflect the postoperative nutrition status of oral tumor patients.
Lo HC, Yang CS, Tsai LJ
Nutrition 2003 Apr;19(4):327-31. doi: 10.1016/s0899-9007(02)01012-2. PMID: 12679166
Increased serum concentration of circulating soluble receptor for interleukin-2 and its effect as a prognostic indicator in cachectic patients with gastric and colorectal cancer.
Shibata M, Takekawa M
Oncology 1999;56(1):54-8. doi: 10.1159/000011930. PMID: 9885378

Clinical prediction guides

Impact on the Nutritional Status and Inflammation of Patients with Cancer Hospitalized after the SARS-CoV-2 Lockdown.
Yárnoz-Esquíroz P, Chopitea A, Olazarán L, Aguas-Ayesa M, Silva C, Vilalta-Lacarra A, Escalada J, Gil-Bazo I, Frühbeck G, Gómez-Ambrosi J
Nutrients 2022 Jul 2;14(13) doi: 10.3390/nu14132754. PMID: 35807934Free PMC Article
Bioelectrical impedance analysis (BIA)-derived phase angle (PA) is a practical aid to nutritional assessment in hospital in-patients.
Player EL, Morris P, Thomas T, Chan WY, Vyas R, Dutton J, Tang J, Alexandre L, Forbes A
Clin Nutr 2019 Aug;38(4):1700-1706. Epub 2018 Aug 17 doi: 10.1016/j.clnu.2018.08.003. PMID: 30170780
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.
Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW
Sci Transl Med 2017 Sep 13;9(407) doi: 10.1126/scitranslmed.aam7621. PMID: 28904227Free PMC Article
Differential responses of IGF-I molecular complexes to military operational field training.
Nindl BC, Castellani JW, Young AJ, Patton JF, Khosravi MJ, Diamandi A, Montain SJ
J Appl Physiol (1985) 2003 Sep;95(3):1083-9. doi: 10.1152/japplphysiol.01148.2002. PMID: 12909598
Increased serum concentration of circulating soluble receptor for interleukin-2 and its effect as a prognostic indicator in cachectic patients with gastric and colorectal cancer.
Shibata M, Takekawa M
Oncology 1999;56(1):54-8. doi: 10.1159/000011930. PMID: 9885378

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