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EBV encephalitis

MedGen UID:
1778372
Concept ID:
C5539656
Disease or Syndrome
Synonyms: Encephalitis caused by Epstein-Barr virus; Encephalitis caused by human herpesvirus 4; Epstein-Barr virus encephalitis
SNOMED CT: Encephalitis caused by Epstein-Barr virus (1163099005); Epstein-Barr virus encephalitis (1163099005); Encephalitis caused by human herpesvirus 4 (1163099005)
 
HPO: HP:0033509

Definition

Inflamation of the brain related to infection by Epstein-Barr virus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEBV encephalitis

Conditions with this feature

Lymphoproliferative syndrome 2
MedGen UID:
767454
Concept ID:
C3554540
Disease or Syndrome
Lymphoproliferative syndrome-2, also known as CD27 deficiency, is an autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impairment in specific antibody function resulting from impaired T cell-dependent B-cell responses and T-cell dysfunction (summary by van Montfrans et al., 2012). The phenotype can vary significantly, from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation (summary by Salzer et al., 2013). For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).

Professional guidelines

PubMed

Rzhevska OO, Khodak LA, Butenko AI, Kvaratskheliya TM, Shtrakh KV, Shevchuk AM, Yashchenko YB
Wiad Lek 2023;76(10):2263-2268. doi: 10.36740/WLek202310120. PMID: 37948724

Recent clinical studies

Etiology

Ridha M, Jones DG, Lerner DP, Vytopil M, Voetsch B, Burns JD, Ramineni A, Raibagkar P
Virol J 2021 Aug 6;18(1):162. doi: 10.1186/s12985-021-01629-6. PMID: 34362398Free PMC Article
Cheng H, Chen D, Peng X, Wu P, Jiang L, Hu Y
BMC Infect Dis 2020 Nov 25;20(1):886. doi: 10.1186/s12879-020-05623-1. PMID: 33238935Free PMC Article
Han J, Kang Z, Xie Y, Li H, Yan H, Song X
Medicine (Baltimore) 2019 Dec;98(51):e18070. doi: 10.1097/MD.0000000000018070. PMID: 31860956Free PMC Article
Dyachenko P, Smiianova O, Kurhanskaya V, Oleshko A, Dyachenko A
Wiad Lek 2018;71(6):1224-1230. PMID: 30267504
Shian WJ, Chi CS
Pediatr Radiol 1996 Sep;26(9):690-3. doi: 10.1007/BF01356839. PMID: 8781116

Diagnosis

Rzhevska OO, Khodak LA, Butenko AI, Kvaratskheliya TM, Shtrakh KV, Shevchuk AM, Yashchenko YB
Wiad Lek 2023;76(10):2263-2268. doi: 10.36740/WLek202310120. PMID: 37948724
Zhang JR, Zhuang S, Xu XD, Song WL, Li KR, Jiang Y, Cheng XY, Shi JJ, Hu WD, Liu CF, Zhang YL
J Neuroimmunol 2023 Sep 15;382:578174. Epub 2023 Aug 7 doi: 10.1016/j.jneuroim.2023.578174. PMID: 37573633
Nakamura J, Yanagida M, Saito K, Kamata Y, Nagashima T, Iwamoto M, Sato T, Sato K
Mod Rheumatol Case Rep 2022 Jun 24;6(2):160-162. doi: 10.1093/mrcr/rxab045. PMID: 34971371
Wang Y, Yang J, Wen Y
Biomed Pharmacother 2022 Jan;145:112392. Epub 2021 Nov 12 doi: 10.1016/j.biopha.2021.112392. PMID: 34781140
Dyachenko P, Smiianova O, Kurhanskaya V, Oleshko A, Dyachenko A
Wiad Lek 2018;71(6):1224-1230. PMID: 30267504

Therapy

Zhang JR, Zhuang S, Xu XD, Song WL, Li KR, Jiang Y, Cheng XY, Shi JJ, Hu WD, Liu CF, Zhang YL
J Neuroimmunol 2023 Sep 15;382:578174. Epub 2023 Aug 7 doi: 10.1016/j.jneuroim.2023.578174. PMID: 37573633
Nakamura J, Yanagida M, Saito K, Kamata Y, Nagashima T, Iwamoto M, Sato T, Sato K
Mod Rheumatol Case Rep 2022 Jun 24;6(2):160-162. doi: 10.1093/mrcr/rxab045. PMID: 34971371
Ridha M, Jones DG, Lerner DP, Vytopil M, Voetsch B, Burns JD, Ramineni A, Raibagkar P
Virol J 2021 Aug 6;18(1):162. doi: 10.1186/s12985-021-01629-6. PMID: 34362398Free PMC Article
Tsuruyama Y, Mori N, Yoshida S, Hayashi T
J Infect Chemother 2020 Jul;26(7):741-744. Epub 2020 Mar 5 doi: 10.1016/j.jiac.2020.02.005. PMID: 32147376
Lau JSY, Low ZM, Abbott I, Shochet L, Kanellis J, Kitching AR, Korman TM
New Microbiol 2017 Jul;40(3):212-217. Epub 2017 May 17 PMID: 28513810

Prognosis

Rzhevska OO, Khodak LA, Butenko AI, Kvaratskheliya TM, Shtrakh KV, Shevchuk AM, Yashchenko YB
Wiad Lek 2023;76(10):2263-2268. doi: 10.36740/WLek202310120. PMID: 37948724
Cheng H, Chen D, Peng X, Wu P, Jiang L, Hu Y
BMC Infect Dis 2020 Nov 25;20(1):886. doi: 10.1186/s12879-020-05623-1. PMID: 33238935Free PMC Article
Tsuruyama Y, Mori N, Yoshida S, Hayashi T
J Infect Chemother 2020 Jul;26(7):741-744. Epub 2020 Mar 5 doi: 10.1016/j.jiac.2020.02.005. PMID: 32147376
Dyachenko P, Smiianova O, Kurhanskaya V, Oleshko A, Dyachenko A
Wiad Lek 2018;71(6):1224-1230. PMID: 30267504
Anninos P, Kotini A, Tamiolakis D, Tsagas N
Acta Neurol Belg 2006 Mar;106(1):26-30. PMID: 16776434

Clinical prediction guides

Rzhevska OO, Khodak LA, Butenko AI, Kvaratskheliya TM, Shtrakh KV, Shevchuk AM, Yashchenko YB
Wiad Lek 2023;76(10):2263-2268. doi: 10.36740/WLek202310120. PMID: 37948724
Tsuruyama Y, Mori N, Yoshida S, Hayashi T
J Infect Chemother 2020 Jul;26(7):741-744. Epub 2020 Mar 5 doi: 10.1016/j.jiac.2020.02.005. PMID: 32147376
Iyer RS, Ramalingam RTC, Akhtar S, Ponnadan S
BMJ Case Rep 2019 Jul 19;12(7) doi: 10.1136/bcr-2019-229879. PMID: 31326904Free PMC Article
Demey HE, Martin JJ, Leus RM, Moeremans CJ, Bossaert LL
Arch Intern Med 1988 Jun;148(6):1459-61. PMID: 2837158

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