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Lung Neuroendocrine Carcinoma

MedGen UID:
1778449
•Concept ID:
C2200127
•
Neoplastic Process
Synonym: High Grade Lung Neuroendocrine Neoplasm

Definition

A high grade malignant neoplasm that arises from the lung and is characterized by the presence of malignant neuroendocrine cells. This category includes small cell lung carcinoma, large cell lung neuroendocrine carcinoma, and combined lung carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Neuroendocrine Carcinoma

Professional guidelines

PubMed

Large cell neuroendocrine lung carcinoma: consensus statement from The British Thoracic Oncology Group and the Association of Pulmonary Pathologists.
Lindsay CR, Shaw EC, Moore DA, Rassl D, Jamal-Hanjani M, Steele N, Naheed S, Dick C, Taylor F, Adderley H, Black F, Summers Y, Evans M, Rice A, Fabre A, Wallace WA, Nicholson S, Haragan A, Taniere P, Nicholson AG, Laing G, Cave J, Forster MD, Blackhall F, Gosney J, Popat S, Kerr KM
Br J Cancer 2021 Oct;125(9):1210-1216. Epub 2021 Sep 6 doi: 10.1038/s41416-021-01407-9. PMID: 34489586Free PMC Article

Recent clinical studies

Etiology

Current understanding of pathogenetic mechanisms in neuroendocrine neoplasms.
Modica R, Liccardi A, Minotta R, Cannavale G, Benevento E, Colao A
Expert Rev Endocrinol Metab 2024 Jan-May;19(1):49-61. Epub 2024 Jan 1 doi: 10.1080/17446651.2023.2279540. PMID: 37936421
Value of immunohistochemistry in crushed areas of pulmonary neuroendocrine carcinoma.
Kuçuk H, Laville D, Dal-Col P, Yvorel V, Sulaiman A, Bayle-Bleuez S, Cosmo P, Vergnon JM, Tiffet O, Desage AL, Forest F
Exp Mol Pathol 2022 Oct;128:104836. Epub 2022 Oct 4 doi: 10.1016/j.yexmp.2022.104836. PMID: 36206956
Prophylactic granulocyte-colony stimulating factor in patients with lung neuroendocrine carcinoma receiving platinum agents plus etoposide.
Watanabe H, Karayama M, Yasui H, Inoue Y, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T
Cancer Treat Res Commun 2021;29:100493. Epub 2021 Nov 20 doi: 10.1016/j.ctarc.2021.100493. PMID: 34844181
Genetic Characteristics of Colorectal Neuroendocrine Carcinoma: More Similar to Colorectal Adenocarcinoma.
Chen L, Liu M, Zhang Y, Guo Y, Chen MH, Chen J
Clin Colorectal Cancer 2021 Jun;20(2):177-185.e13. Epub 2020 Sep 9 doi: 10.1016/j.clcc.2020.09.001. PMID: 33041225
Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens.
Shimada Y, Niho S, Ishii G, Hishida T, Yoshida J, Nishimura M, Yoh K, Goto K, Ohmatsu H, Ohe Y, Nagai K
Lung Cancer 2012 Mar;75(3):368-73. Epub 2011 Sep 13 doi: 10.1016/j.lungcan.2011.08.012. PMID: 21920624

Diagnosis

Utility of secretagogin as a marker for the diagnosis of lung neuroendocrine carcinoma.
Baykara Y, Xiao Y, Yang D, Yakirevich E, Maleki S, Garcia-Moliner M, Wang LJ, Huang CK, Lu S
Virchows Arch 2022 Jul;481(1):31-39. Epub 2022 Mar 31 doi: 10.1007/s00428-022-03312-9. PMID: 35357570
Expression of SATB2 in Neuroendocrine Carcinomas of the Lung: Frequent Immunopositivity of Large Cell Neuroendocrine Carcinoma with a Diagnostic Pitfall.
Inoue H, Matsushima J, Kobayashi S, Sairenchi T, Hirata H, Chida M, Ota S, Ban S, Matsumura Y
Int J Surg Pathol 2022 Apr;30(2):151-159. Epub 2021 Dec 16 doi: 10.1177/10668969211065757. PMID: 34913369
Pituitary Metastasis of Lung Neuroendocrine Carcinoma Mimicking Pituitary Adenoma:Case Report and Literature Review.
Liu X, Wang R, Li M, Chen G
Front Endocrinol (Lausanne) 2021;12:678947. Epub 2021 Jul 14 doi: 10.3389/fendo.2021.678947. PMID: 34335467Free PMC Article
Two cases of lung neuroendocrine carcinoma with carcinoid morphology.
Inafuku K, Yokose T, Ito H, Eriguchi D, Samejima J, Nagashima T, Nakayama H, Suzuki M, Yamada K, Masuda M
Diagn Pathol 2019 Sep 12;14(1):104. doi: 10.1186/s13000-019-0886-1. PMID: 31511024Free PMC Article
Pituitary metastasis of lung neuroendocrine carcinoma: case report and literature review.
Siqueira PF, Mathez AL, Pedretti DB, Abucham J
Arch Endocrinol Metab 2015 Dec;59(6):548-53. doi: 10.1590/2359-3997000000139. PMID: 26677090

Therapy

Prophylactic granulocyte-colony stimulating factor in patients with lung neuroendocrine carcinoma receiving platinum agents plus etoposide.
Watanabe H, Karayama M, Yasui H, Inoue Y, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T
Cancer Treat Res Commun 2021;29:100493. Epub 2021 Nov 20 doi: 10.1016/j.ctarc.2021.100493. PMID: 34844181
Marked response to nab-paclitaxel in EGFR mutated lung neuroendocrine carcinoma: A case report.
Liang JY, Tong F, Gu FF, Liu YY, Zeng YL, Hong XH, Zhang K, Liu L
Medicine (Baltimore) 2017 May;96(21):e6985. doi: 10.1097/MD.0000000000006985. PMID: 28538405Free PMC Article
Clinical features of unresectable high-grade lung neuroendocrine carcinoma diagnosed using biopsy specimens.
Shimada Y, Niho S, Ishii G, Hishida T, Yoshida J, Nishimura M, Yoh K, Goto K, Ohmatsu H, Ohe Y, Nagai K
Lung Cancer 2012 Mar;75(3):368-73. Epub 2011 Sep 13 doi: 10.1016/j.lungcan.2011.08.012. PMID: 21920624
Clinical features and management of ectopic ACTH syndrome at a single institute in Japan.
Doi M, Sugiyama T, Izumiyama H, Yoshimoto T, Hirata Y
Endocr J 2010;57(12):1061-9. Epub 2010 Nov 9 doi: 10.1507/endocrj.k10e-265. PMID: 21076235
Extensive expression of collapsin response mediator protein 5 (CRMP5) is a specific marker of high-grade lung neuroendocrine carcinoma.
Meyronet D, Massoma P, Thivolet F, Chalabreysse L, Rogemond V, Schlama A, Honnorat J, Thomasset N
Am J Surg Pathol 2008 Nov;32(11):1699-708. doi: 10.1097/PAS.0b013e31817dc37c. PMID: 18769332

Prognosis

CLINICAL CASE OF NON-TYPICAL METASTASIS OF NEUROENDOCRINE LUNG CARCINOMA TO THE VASCULAR MEMBRANE OF THE EYE.
Zakhartseva LM, Chytaieva HE, Artemov OV
Exp Oncol 2022 Aug;44(2):169-173. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-2.17969. PMID: 35964644
Genetic Characteristics of Colorectal Neuroendocrine Carcinoma: More Similar to Colorectal Adenocarcinoma.
Chen L, Liu M, Zhang Y, Guo Y, Chen MH, Chen J
Clin Colorectal Cancer 2021 Jun;20(2):177-185.e13. Epub 2020 Sep 9 doi: 10.1016/j.clcc.2020.09.001. PMID: 33041225
Intramedullary Spinal Cord Metastasis from Primary Lung Neuroendocrine Carcinoma: A Case Report and Operative Video.
Ginalis EE, Jumah F, Raju B, Xiong Z, Nanda A
World Neurosurg 2021 Jan;145:426-431. Epub 2020 Aug 20 doi: 10.1016/j.wneu.2020.08.103. PMID: 32827737
Two cases of lung neuroendocrine carcinoma with carcinoid morphology.
Inafuku K, Yokose T, Ito H, Eriguchi D, Samejima J, Nagashima T, Nakayama H, Suzuki M, Yamada K, Masuda M
Diagn Pathol 2019 Sep 12;14(1):104. doi: 10.1186/s13000-019-0886-1. PMID: 31511024Free PMC Article
Pituitary metastasis of lung neuroendocrine carcinoma: case report and literature review.
Siqueira PF, Mathez AL, Pedretti DB, Abucham J
Arch Endocrinol Metab 2015 Dec;59(6):548-53. doi: 10.1590/2359-3997000000139. PMID: 26677090

Clinical prediction guides

CLINICAL CASE OF NON-TYPICAL METASTASIS OF NEUROENDOCRINE LUNG CARCINOMA TO THE VASCULAR MEMBRANE OF THE EYE.
Zakhartseva LM, Chytaieva HE, Artemov OV
Exp Oncol 2022 Aug;44(2):169-173. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-2.17969. PMID: 35964644
Expression of SATB2 in Neuroendocrine Carcinomas of the Lung: Frequent Immunopositivity of Large Cell Neuroendocrine Carcinoma with a Diagnostic Pitfall.
Inoue H, Matsushima J, Kobayashi S, Sairenchi T, Hirata H, Chida M, Ota S, Ban S, Matsumura Y
Int J Surg Pathol 2022 Apr;30(2):151-159. Epub 2021 Dec 16 doi: 10.1177/10668969211065757. PMID: 34913369

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