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African Swine Fever

MedGen UID:
1779
•Concept ID:
C0001752
•
Disease or Syndrome
Synonyms: African Swine Fever Virus Infection; Asfivirus Infection; Asfivirus Infections; Infection, Asfivirus; Infections, Asfivirus; Swine Fever, African; Wart Hog Disease; Wart-Hog Disease; Wart-Hog Diseases

Definition

A sometimes fatal ASFIVIRUS infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros). [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAfrican Swine Fever

Professional guidelines

PubMed

Quantitative risk assessment of African swine fever virus introduction to Japan via pork products brought in air passengers' luggage.
Ito S, Jurado C, Sánchez-Vizcaíno JM, Isoda N
Transbound Emerg Dis 2020 Mar;67(2):894-905. Epub 2019 Nov 17 doi: 10.1111/tbed.13414. PMID: 31692238
A rapid risk assessment of African swine fever introduction and spread in Japan based on expert opinions.
Sugiura K, Haga T
J Vet Med Sci 2018 Nov 23;80(11):1743-1746. Epub 2018 Oct 4 doi: 10.1292/jvms.18-0543. PMID: 30282884Free PMC Article
Quantitative risk assessment case study: smuggled meats as disease vectors.
Wooldridge M, Hartnett E, Cox A, Seaman M
Rev Sci Tech 2006 Apr;25(1):105-17. doi: 10.20506/rst.25.1.1651. PMID: 16796040

Recent clinical studies

Etiology

One hundred years of African swine fever in Africa: Where have we been, where are we now, where are we going?
Penrith ML, Kivaria FM
Transbound Emerg Dis 2022 Sep;69(5):e1179-e1200. Epub 2022 Feb 14 doi: 10.1111/tbed.14466. PMID: 35104041
The risk from African swine fever.
Jarvis S
Vet Rec 2018 Nov 3;183(17):515. doi: 10.1136/vr.k4609. PMID: 30389859
Glycans with Antiviral Activity from Marine Organisms.
Grice ID, Mariottini GL
Results Probl Cell Differ 2018;65:439-475. doi: 10.1007/978-3-319-92486-1_20. PMID: 30083931
Tick-borne viruses.
Bartíková P, Holíková V, Kazimírová M, Štibrániová I
Acta Virol 2017;61(4):413-427. doi: 10.4149/av_2017_403. PMID: 29186958
Tick-borne viruses in Europe.
Hubálek Z, Rudolf I
Parasitol Res 2012 Jul;111(1):9-36. Epub 2012 Apr 18 doi: 10.1007/s00436-012-2910-1. PMID: 22526290

Diagnosis

Highly efficient and robust π-FISH rainbow for multiplexed in situ detection of diverse biomolecules.
Tao Y, Zhou X, Sun L, Lin D, Cai H, Chen X, Zhou W, Yang B, Hu Z, Yu J, Zhang J, Yang X, Yang F, Shen B, Qi W, Fu Z, Dai J, Cao G
Nat Commun 2023 Jan 27;14(1):443. doi: 10.1038/s41467-023-36137-4. PMID: 36707540Free PMC Article
A one-pot CRISPR/Cas13a-based contamination-free biosensor for low-cost and rapid nucleic acid diagnostics.
Hu F, Liu Y, Zhao S, Zhang Z, Li X, Peng N, Jiang Z
Biosens Bioelectron 2022 Apr 15;202:113994. Epub 2022 Jan 13 doi: 10.1016/j.bios.2022.113994. PMID: 35042129Free PMC Article
Exploiting the orthogonal CRISPR-Cas12a/Cas13a trans-cleavage for dual-gene virus detection using a handheld device.
Tian T, Qiu Z, Jiang Y, Zhu D, Zhou X
Biosens Bioelectron 2022 Jan 15;196:113701. Epub 2021 Oct 10 doi: 10.1016/j.bios.2021.113701. PMID: 34653714
CRISPR-Cas systems for diagnosing infectious diseases.
Kostyusheva A, Brezgin S, Babin Y, Vasilyeva I, Glebe D, Kostyushev D, Chulanov V
Methods 2022 Jul;203:431-446. Epub 2021 Apr 9 doi: 10.1016/j.ymeth.2021.04.007. PMID: 33839288Free PMC Article
Uses of flow cytometry in virology.
McSharry JJ
Clin Microbiol Rev 1994 Oct;7(4):576-604. doi: 10.1128/CMR.7.4.576. PMID: 7530594Free PMC Article

Therapy

The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice.
Feng Z, Chen J, Liang W, Chen W, Li Z, Chen Q, Cai S
Virol J 2020 Nov 16;17(1):180. doi: 10.1186/s12985-020-01450-7. PMID: 33198749Free PMC Article
Impact of participatory training of smallholder pig farmers on knowledge, attitudes and practices regarding biosecurity for the control of African swine fever in Uganda.
Dione MM, Dohoo I, Ndiwa N, Poole J, Ouma E, Amia WC, Wieland B
Transbound Emerg Dis 2020 Nov;67(6):2482-2493. Epub 2020 May 17 doi: 10.1111/tbed.13587. PMID: 32311216Free PMC Article
A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs.
Chen W, Zhao D, He X, Liu R, Wang Z, Zhang X, Li F, Shan D, Chen H, Zhang J, Wang L, Wen Z, Wang X, Guan Y, Liu J, Bu Z
Sci China Life Sci 2020 May;63(5):623-634. Epub 2020 Mar 1 doi: 10.1007/s11427-020-1657-9. PMID: 32124180Free PMC Article
Smallholders' perceptions on biosecurity and disease control in relation to African swine fever in an endemically infected area in Northern Uganda.
Chenais E, Lewerin SS, Boqvist S, Ståhl K, Alike S, Nokorach B, Emanuelson U
BMC Vet Res 2019 Aug 5;15(1):279. doi: 10.1186/s12917-019-2005-7. PMID: 31383024Free PMC Article
Polyvalent 2D Entry Inhibitors for Pseudorabies and African Swine Fever Virus.
Ziem B, Rahn J, Donskyi I, Silberreis K, Cuellar L, Dernedde J, Keil G, Mettenleiter TC, Haag R
Macromol Biosci 2017 Jun;17(6) Epub 2017 Mar 15 doi: 10.1002/mabi.201600499. PMID: 28296132

Prognosis

Stability analysis and optimal control of a fractional-order model for African swine fever.
Shi R, Li Y, Wang C
Virus Res 2020 Oct 15;288:198111. Epub 2020 Aug 11 doi: 10.1016/j.virusres.2020.198111. PMID: 32791169
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
Modelling African swine fever presence and reported abundance in the Russian Federation using national surveillance data from 2007 to 2014.
Vergne T, Korennoy F, Combelles L, Gogin A, Pfeiffer DU
Spat Spatiotemporal Epidemiol 2016 Nov;19:70-77. Epub 2016 Jun 16 doi: 10.1016/j.sste.2016.06.002. PMID: 27839582
A review of pig pathology in Tanzania.
Wilson RT, Swai E
Trop Anim Health Prod 2013 Aug;45(6):1269-75. Epub 2013 Jun 5 doi: 10.1007/s11250-013-0426-z. PMID: 23733144
The lesional changes and pathogenesis in the kidney in African swine fever.
Hervás J, Gómez-Villamandos JC, Méndez A, Carrasco L, Sierra MA
Vet Res Commun 1996;20(3):285-99. doi: 10.1007/BF00366926. PMID: 8739527

Clinical prediction guides

Comparison of the Virulence of Korean African Swine Fever Isolates from Pig Farms during 2019-2021.
Cho KH, Hong SK, Jang MK, Ryu JH, Kim HJ, Lee YR, Roh IS, Sohn HJ, Kang HE, Park JY
Viruses 2022 Nov 13;14(11) doi: 10.3390/v14112512. PMID: 36423121Free PMC Article
Has the Spread of African Swine Fever in the European Union Been Impacted by COVID-19 Pandemic?
Biondi V, Monti S, Landi A, Pugliese M, Zema E, Passantino A
Int J Environ Res Public Health 2022 Apr 28;19(9) doi: 10.3390/ijerph19095360. PMID: 35564754Free PMC Article
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Wang Q, Zhou L, Wang J, Su D, Li D, Du Y, Yang G, Zhang G, Chu B
Viruses 2022 Feb 15;14(2) doi: 10.3390/v14020394. PMID: 35215987Free PMC Article
Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.
De Groot AS, Moise L, Terry F, Gutierrez AH, Hindocha P, Richard G, Hoft DF, Ross TM, Noe AR, Takahashi Y, Kotraiah V, Silk SE, Nielsen CM, Minassian AM, Ashfield R, Ardito M, Draper SJ, Martin WD
Front Immunol 2020;11:442. Epub 2020 Apr 7 doi: 10.3389/fimmu.2020.00442. PMID: 32318055Free PMC Article
Transmission of pathogens by Stomoxys flies (Diptera, Muscidae): a review.
Baldacchino F, Muenworn V, Desquesnes M, Desoli F, Charoenviriyaphap T, Duvallet G
Parasite 2013;20:26. Epub 2013 Aug 29 doi: 10.1051/parasite/2013026. PMID: 23985165Free PMC Article

Recent systematic reviews

Arboviruses in Mammals in the Neotropics: A Systematic Review to Strengthen Epidemiological Monitoring Strategies and Conservation Medicine.
García-Romero C, Carrillo Bilbao GA, Navarro JC, Martin-Solano S, Saegerman C
Viruses 2023 Feb 1;15(2) doi: 10.3390/v15020417. PMID: 36851630Free PMC Article

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