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Glomerular extracapillary fibrin

MedGen UID:
1779145
•Concept ID:
C5539561
•
Finding
HPO: HP:0033396

Definition

Presence of ropey, eosinophilic material (brght red on Trichrome staining) consistent with extracapillary fibrin outside of capillary lumina. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular extracapillary fibrin

Recent clinical studies

Etiology

Urinary thrombin: a novel marker of glomerular inflammation for the diagnosis of crescentic glomerulonephritis (prospective observational study).
Kitamoto Y, Arizono K, Fukui H, Tomita K, Kitamura H, Taguma Y, Imamura T
PLoS One 2015;10(3):e0118704. Epub 2015 Mar 5 doi: 10.1371/journal.pone.0118704. PMID: 25742509Free PMC Article
Structure and development of the glomerular crescent.
Morita T, Suzuki Y, Churg J
Am J Pathol 1973 Sep;72(3):349-68. PMID: 4125698Free PMC Article

Diagnosis

Urinary thrombin: a novel marker of glomerular inflammation for the diagnosis of crescentic glomerulonephritis (prospective observational study).
Kitamoto Y, Arizono K, Fukui H, Tomita K, Kitamura H, Taguma Y, Imamura T
PLoS One 2015;10(3):e0118704. Epub 2015 Mar 5 doi: 10.1371/journal.pone.0118704. PMID: 25742509Free PMC Article
What is the difference between IgA nephropathy and Henoch-Schönlein purpura nephritis?
Davin JC, Ten Berge IJ, Weening JJ
Kidney Int 2001 Mar;59(3):823-34. doi: 10.1046/j.1523-1755.2001.059003823.x. PMID: 11231337
Immunoperoxidase autopsy study of crescentic glomerulonephritis with extracapillary proliferation.
Tóth T
Int Urol Nephrol 1989;21(1):97-104. doi: 10.1007/BF02549907. PMID: 2654055
Experience in the diagnosis of glomerulonephritis using combined light microscopical, ultrastructural and immunofluorescence techniques--an analysis of 134 cases.
Dische FE, Parsons V
Histopathology 1977 Sep;1(5):331-62. doi: 10.1111/j.1365-2559.1977.tb01672.x. PMID: 355083

Therapy

Urinary thrombin: a novel marker of glomerular inflammation for the diagnosis of crescentic glomerulonephritis (prospective observational study).
Kitamoto Y, Arizono K, Fukui H, Tomita K, Kitamura H, Taguma Y, Imamura T
PLoS One 2015;10(3):e0118704. Epub 2015 Mar 5 doi: 10.1371/journal.pone.0118704. PMID: 25742509Free PMC Article

Prognosis

Urokinase synthesis and binding by glomerular epithelial cells in culture.
Rondeau E, Ochi S, Lacave R, He CJ, Medcalf R, Delarue F, Sraer JD
Kidney Int 1989 Oct;36(4):593-600. doi: 10.1038/ki.1989.235. PMID: 2554052
Rapidly progressive glomerulonephritis: classification, pathogenetic mechanisms, and therapy.
Couser WG
Am J Kidney Dis 1988 Jun;11(6):449-64. doi: 10.1016/s0272-6386(88)80079-9. PMID: 3287904
Intravascular clotting preceding crescent formation in a patient with Wegner's granulomatosis and rapidly progressive glomerulonephritis.
Juncos LI, Alexander RW, Marbury TC
Nephron 1979;24(1):17-20. doi: 10.1159/000181676. PMID: 492404

Clinical prediction guides

Urinary thrombin: a novel marker of glomerular inflammation for the diagnosis of crescentic glomerulonephritis (prospective observational study).
Kitamoto Y, Arizono K, Fukui H, Tomita K, Kitamura H, Taguma Y, Imamura T
PLoS One 2015;10(3):e0118704. Epub 2015 Mar 5 doi: 10.1371/journal.pone.0118704. PMID: 25742509Free PMC Article
Constitutive expression and modulation of the functional thrombin receptor in the human kidney.
Xu Y, Zacharias U, Peraldi MN, He CJ, Lu C, Sraer JD, Brass LF, Rondeau E
Am J Pathol 1995 Jan;146(1):101-10. PMID: 7856719Free PMC Article
Relationship of intraglomerular coagulation and platelet aggregation to glomerular sclerosis.
Ono T, Kanatsu K, Doi T, Sekita K, Onoe C, Nagai H, Muso E, Yoshida H, Tamura T, Kawai C
Nephron 1991;58(4):429-36. doi: 10.1159/000186475. PMID: 1922608
Urokinase synthesis and binding by glomerular epithelial cells in culture.
Rondeau E, Ochi S, Lacave R, He CJ, Medcalf R, Delarue F, Sraer JD
Kidney Int 1989 Oct;36(4):593-600. doi: 10.1038/ki.1989.235. PMID: 2554052
Identification and cellular localization of plasminogen activators from human glomeruli.
Angles-Cano E, Rondeau E, Delarue F, Hagege J, Sultan Y, Sraer JD
Thromb Haemost 1985 Oct 30;54(3):688-92. PMID: 3937266

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