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Multinucleated visceral epithelial cells

MedGen UID:: 1779625
•Concept ID:: C5539492
•: Finding

Synonyms:	Multinucleated podocytes; Podocyte multinucleation

HPO:	HP:0033297

Definition

Visceral epithelial cells with more than two nuclei. Can be observed on light or ultrastructral microscopy. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMultinucleated visceral epithelial cells

Abnormality of the kidney
- Abnormal renal morphology
  - Abnormal nephron morphology
    - Abnormal renal corpuscle morphology
      - Abnormal Bowman capsule morphology
        Abnormal glomerular visceral epithelial cell morphology
        Multinucleated visceral epithelial cells

Recent clinical studies

Diagnosis

Treatment of a patient with malignant mesothelioma with interferon-alpha 2 based on in vitro sensitivity tests.

Sexl V, Wagner L, Wiesholzer M, Presterl E, Base W
Clin Investig 1994 Mar;72(4):317-20. doi: 10.1007/BF00180050. PMID: 8043983

Therapy

Treatment of a patient with malignant mesothelioma with interferon-alpha 2 based on in vitro sensitivity tests.

Sexl V, Wagner L, Wiesholzer M, Presterl E, Base W
Clin Investig 1994 Mar;72(4):317-20. doi: 10.1007/BF00180050. PMID: 8043983

Clinical prediction guides

In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells.

Leikam C, Hufnagel AL, Otto C, Murphy DJ, Mühling B, Kneitz S, Nanda I, Schmid M, Wagner TU, Haferkamp S, Bröcker EB, Schartl M, Meierjohann S
Cell Death Dis 2015 Apr 2;6(4):e1711. doi: 10.1038/cddis.2015.71. PMID: 25837487 Free PMC Article

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Clinical resources

ClinicalTrials.gov

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