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Increased circulating brain natriuretic peptide concentration

MedGen UID:
1779799
Concept ID:
C5539662
Finding
Synonyms: Elevated circulating BNP concentration; Increased B-type natriuretic peptide; Increased ventricular natriuretic peptide
 
HPO: HP:0033534

Definition

An increased concentration of brain natriuretic peptide in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating brain natriuretic peptide concentration

Conditions with this feature

Dilated cardiomyopathy 1D
MedGen UID:
316943
Concept ID:
C1832243
Disease or Syndrome
Left ventricular noncompaction is a heart (cardiac) muscle disorder that occurs when the lower left chamber of the heart (left ventricle), which helps the heart pump blood, does not develop correctly. Instead of the muscle being smooth and firm, the cardiac muscle in the left ventricle is thick and appears spongy. The abnormal cardiac muscle is weak and has an impaired ability to pump blood because it either cannot completely contract or it cannot completely relax. For the heart to pump blood normally, cardiac muscle must contract and relax fully.\n\nSome individuals with left ventricular noncompaction experience no symptoms at all; others have heart problems that can include sudden cardiac death. Additional signs and symptoms include abnormal blood clots, irregular heart rhythm (arrhythmia), a sensation of fluttering or pounding in the chest (palpitations), extreme fatigue during exercise (exercise intolerance), shortness of breath (dyspnea), fainting (syncope), swelling of the legs (lymphedema), and trouble laying down flat. Some affected individuals have features of other heart defects. Left ventricular noncompaction can be diagnosed at any age, from birth to late adulthood. Approximately two-thirds of individuals with left ventricular noncompaction develop heart failure.
Cardiomyopathy, dilated, 2F
MedGen UID:
1802616
Concept ID:
C5676917
Disease or Syndrome
Dilated cardiomyopathy-2F (CMD2F) is an autosomal recessive early-onset cardiomyopathy associated with refractory ventricular arrhythmias and severe heart failure requiring placement of a left ventricular assist device (Hakui et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of dilated cardiomyopathy, see 115200.

Professional guidelines

PubMed

Merz WM, Kübler K, Fimmers R, Stoffel-Wagner B, Geipel A, Gembruch U
Pediatr Res 2012 Aug;72(2):174-8. doi: 10.1038/pr.2012.53. PMID: 22546865
Leistner DM, Klotsche J, Pieper L, Stalla GK, Lehnert H, Silber S, März W, Wittchen HU, Zeiher AM; DETECT Study Group
Clin Chem 2012 Jan;58(1):200-8. Epub 2011 Dec 7 doi: 10.1373/clinchem.2011.174292. PMID: 22156668
Yilmaz VT, Eken C, Avci AB, Duman A, Tuna Y, Akin M, Yildirim B
Turk J Gastroenterol 2010 Dec;21(4):381-6. doi: 10.4318/tjg.2010.0124. PMID: 21331991

Recent clinical studies

Etiology

Wei H, Wu J, Wang H, Huang J, Li C, Zhang Y, Song Y, Zhou Z, Sun Y, Xiao L, Peng L, Chen C, Zhao C, Wang DW
J Intern Med 2023 Oct;294(4):515-530. Epub 2023 May 30 doi: 10.1111/joim.13653. PMID: 37184278
Boorsma EM, Ter Maaten JM, Damman K, van Essen BJ, Zannad F, van Veldhuisen DJ, Samani NJ, Dickstein K, Metra M, Filippatos G, Lang CC, Ng L, Anker SD, Cleland JG, Pellicori P, Gansevoort RT, Heerspink HJL, Voors AA, Emmens JE
Eur Heart J 2023 Feb 1;44(5):368-380. doi: 10.1093/eurheartj/ehac528. PMID: 36148485Free PMC Article
Gupta DK, Walford GA, Ma Y, Jarolim P, Wang TJ; DPP Research Group
PLoS One 2020;15(2):e0229280. Epub 2020 Feb 21 doi: 10.1371/journal.pone.0229280. PMID: 32084251Free PMC Article
Myhre PL, Vaduganathan M, Claggett B, Packer M, Desai AS, Rouleau JL, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD
J Am Coll Cardiol 2019 Mar 26;73(11):1264-1272. Epub 2019 Mar 4 doi: 10.1016/j.jacc.2019.01.018. PMID: 30846338Free PMC Article
De Santo NG, Cirillo M, Perna A, Pollastro RM, Frangiosa A, Di Stazio E, Iorio L, Andrea Di Leo V, Anastasio P
Semin Nephrol 2005 Nov;25(6):404-7. doi: 10.1016/j.semnephrol.2005.05.010. PMID: 16298263

Diagnosis

Boorsma EM, Ter Maaten JM, Damman K, van Essen BJ, Zannad F, van Veldhuisen DJ, Samani NJ, Dickstein K, Metra M, Filippatos G, Lang CC, Ng L, Anker SD, Cleland JG, Pellicori P, Gansevoort RT, Heerspink HJL, Voors AA, Emmens JE
Eur Heart J 2023 Feb 1;44(5):368-380. doi: 10.1093/eurheartj/ehac528. PMID: 36148485Free PMC Article
Gupta DK, Walford GA, Ma Y, Jarolim P, Wang TJ; DPP Research Group
PLoS One 2020;15(2):e0229280. Epub 2020 Feb 21 doi: 10.1371/journal.pone.0229280. PMID: 32084251Free PMC Article
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Peacock WF
Clin Chem Lab Med 2014 Oct;52(10):1433-5. doi: 10.1515/cclm-2014-0222. PMID: 24756062
De Santo NG, Cirillo M, Perna A, Pollastro RM, Frangiosa A, Di Stazio E, Iorio L, Andrea Di Leo V, Anastasio P
Semin Nephrol 2005 Nov;25(6):404-7. doi: 10.1016/j.semnephrol.2005.05.010. PMID: 16298263

Therapy

Gupta DK, Walford GA, Ma Y, Jarolim P, Wang TJ; DPP Research Group
PLoS One 2020;15(2):e0229280. Epub 2020 Feb 21 doi: 10.1371/journal.pone.0229280. PMID: 32084251Free PMC Article
Myhre PL, Vaduganathan M, Claggett B, Packer M, Desai AS, Rouleau JL, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD
J Am Coll Cardiol 2019 Mar 26;73(11):1264-1272. Epub 2019 Mar 4 doi: 10.1016/j.jacc.2019.01.018. PMID: 30846338Free PMC Article
Bachmann KN, Deger SM, Alsouqi A, Huang S, Xu M, Ferguson JF, Su YR, Niswender KD, Ikizler TA, Wang TJ
PLoS One 2018;13(5):e0196869. Epub 2018 May 14 doi: 10.1371/journal.pone.0196869. PMID: 29758041Free PMC Article
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Antila S, Sundberg S, Lehtonen LA
Clin Pharmacokinet 2007;46(7):535-52. doi: 10.2165/00003088-200746070-00001. PMID: 17596101

Prognosis

Wei H, Wu J, Wang H, Huang J, Li C, Zhang Y, Song Y, Zhou Z, Sun Y, Xiao L, Peng L, Chen C, Zhao C, Wang DW
J Intern Med 2023 Oct;294(4):515-530. Epub 2023 May 30 doi: 10.1111/joim.13653. PMID: 37184278
Boorsma EM, Ter Maaten JM, Damman K, van Essen BJ, Zannad F, van Veldhuisen DJ, Samani NJ, Dickstein K, Metra M, Filippatos G, Lang CC, Ng L, Anker SD, Cleland JG, Pellicori P, Gansevoort RT, Heerspink HJL, Voors AA, Emmens JE
Eur Heart J 2023 Feb 1;44(5):368-380. doi: 10.1093/eurheartj/ehac528. PMID: 36148485Free PMC Article
Myhre PL, Vaduganathan M, Claggett B, Packer M, Desai AS, Rouleau JL, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD
J Am Coll Cardiol 2019 Mar 26;73(11):1264-1272. Epub 2019 Mar 4 doi: 10.1016/j.jacc.2019.01.018. PMID: 30846338Free PMC Article
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Peacock WF
Clin Chem Lab Med 2014 Oct;52(10):1433-5. doi: 10.1515/cclm-2014-0222. PMID: 24756062

Clinical prediction guides

Wei H, Wu J, Wang H, Huang J, Li C, Zhang Y, Song Y, Zhou Z, Sun Y, Xiao L, Peng L, Chen C, Zhao C, Wang DW
J Intern Med 2023 Oct;294(4):515-530. Epub 2023 May 30 doi: 10.1111/joim.13653. PMID: 37184278
Myhre PL, Vaduganathan M, Claggett B, Packer M, Desai AS, Rouleau JL, Zile MR, Swedberg K, Lefkowitz M, Shi V, McMurray JJV, Solomon SD
J Am Coll Cardiol 2019 Mar 26;73(11):1264-1272. Epub 2019 Mar 4 doi: 10.1016/j.jacc.2019.01.018. PMID: 30846338Free PMC Article
Egom EE
J Cardiovasc Transl Res 2015 Apr;8(3):149-57. Epub 2015 Mar 14 doi: 10.1007/s12265-015-9619-3. PMID: 25771949
Peacock WF
Clin Chem Lab Med 2014 Oct;52(10):1433-5. doi: 10.1515/cclm-2014-0222. PMID: 24756062
De Santo NG, Cirillo M, Perna A, Pollastro RM, Frangiosa A, Di Stazio E, Iorio L, Andrea Di Leo V, Anastasio P
Semin Nephrol 2005 Nov;25(6):404-7. doi: 10.1016/j.semnephrol.2005.05.010. PMID: 16298263

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