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Tissue ischemia

MedGen UID:
1780068
•Concept ID:
C5539563
•
Pathologic Function
HPO: HP:0033401

Definition

Ischemia is defined as a restriction of arterial blood supply to a tissue associated with insufficient oxygenation to support the metabolis requirements of the tissue. Depending on the involved tissues, clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis. Additional associated manifestations include hemodynamic parameters (reduced blood pressure distal to the site of restricted arterial supply) and angiographic evidence of arterial occclusion. [from HPO]

Professional guidelines

PubMed

Treatment Guidelines in Vasculitis.
Kermani TA, Warrington KJ, Dua AB
Rheum Dis Clin North Am 2022 Aug;48(3):705-724. Epub 2022 Jul 5 doi: 10.1016/j.rdc.2022.03.006. PMID: 35953232
Sickle cell disease: current treatment and emerging therapies.
Neumayr LD, Hoppe CC, Brown C
Am J Manag Care 2019 Nov;25(18 Suppl):S335-S343. PMID: 31809007
Giant Cell Arteritis (GCA): Pathogenesis, Clinical Aspects and Treatment Approaches.
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250

Recent clinical studies

Etiology

Treatment Guidelines in Vasculitis.
Kermani TA, Warrington KJ, Dua AB
Rheum Dis Clin North Am 2022 Aug;48(3):705-724. Epub 2022 Jul 5 doi: 10.1016/j.rdc.2022.03.006. PMID: 35953232
Treatments in Ischemic Stroke: Current and Future.
Mosconi MG, Paciaroni M
Eur Neurol 2022;85(5):349-366. Epub 2022 Aug 2 doi: 10.1159/000525822. PMID: 35917794
Nonsurgical Rhinoplasty.
Rohrich R, Alleyne B, Novak M, Bellamy J, Chamata E
Clin Plast Surg 2022 Jan;49(1):191-195. Epub 2021 Oct 9 doi: 10.1016/j.cps.2021.08.005. PMID: 34782136
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators
N Engl J Med 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9 doi: 10.1056/NEJMoa1806311. PMID: 30625070
An overview of co-morbidities and the development of pressure ulcers among older adults.
Jaul E, Barron J, Rosenzweig JP, Menczel J
BMC Geriatr 2018 Dec 11;18(1):305. doi: 10.1186/s12877-018-0997-7. PMID: 30537947Free PMC Article

Diagnosis

Treatment Guidelines in Vasculitis.
Kermani TA, Warrington KJ, Dua AB
Rheum Dis Clin North Am 2022 Aug;48(3):705-724. Epub 2022 Jul 5 doi: 10.1016/j.rdc.2022.03.006. PMID: 35953232
Treatments in Ischemic Stroke: Current and Future.
Mosconi MG, Paciaroni M
Eur Neurol 2022;85(5):349-366. Epub 2022 Aug 2 doi: 10.1159/000525822. PMID: 35917794
Giant Cell Arteritis (GCA): Pathogenesis, Clinical Aspects and Treatment Approaches.
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250
Acute compartment syndrome.
Schmidt AH
Injury 2017 Jun;48 Suppl 1:S22-S25. Epub 2017 Apr 24 doi: 10.1016/j.injury.2017.04.024. PMID: 28449851
Acute Compartment Syndrome.
Schmidt AH
Orthop Clin North Am 2016 Jul;47(3):517-25. doi: 10.1016/j.ocl.2016.02.001. PMID: 27241376

Therapy

Treatments in Ischemic Stroke: Current and Future.
Mosconi MG, Paciaroni M
Eur Neurol 2022;85(5):349-366. Epub 2022 Aug 2 doi: 10.1159/000525822. PMID: 35917794
Giant Cell Arteritis (GCA): Pathogenesis, Clinical Aspects and Treatment Approaches.
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250
Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura.
Scully M, Cataland SR, Peyvandi F, Coppo P, Knöbl P, Kremer Hovinga JA, Metjian A, de la Rubia J, Pavenski K, Callewaert F, Biswas D, De Winter H, Zeldin RK; HERCULES Investigators
N Engl J Med 2019 Jan 24;380(4):335-346. Epub 2019 Jan 9 doi: 10.1056/NEJMoa1806311. PMID: 30625070
Acute compartment syndrome.
Schmidt AH
Injury 2017 Jun;48 Suppl 1:S22-S25. Epub 2017 Apr 24 doi: 10.1016/j.injury.2017.04.024. PMID: 28449851
Acute Compartment Syndrome.
Schmidt AH
Orthop Clin North Am 2016 Jul;47(3):517-25. doi: 10.1016/j.ocl.2016.02.001. PMID: 27241376

Prognosis

Endothelial progenitor cells in the host defense response.
Shi X, Seidle KA, Simms KJ, Dong F, Chilian WM, Zhang P
Pharmacol Ther 2023 Jan;241:108315. Epub 2022 Nov 24 doi: 10.1016/j.pharmthera.2022.108315. PMID: 36436689Free PMC Article
Surgical Escharotomy and Decompressive Therapies in Burns.
Butts CC, Holmes JH, Carter JE
J Burn Care Res 2020 Feb 19;41(2):263-269. doi: 10.1093/jbcr/irz152. PMID: 31504609
Giant Cell Arteritis (GCA): Pathogenesis, Clinical Aspects and Treatment Approaches.
Ciofalo A, Gulotta G, Iannella G, Pasquariello B, Manno A, Angeletti D, Pace A, Greco A, Altissimi G, de Vincentiis M, Magliulo G
Curr Rheumatol Rev 2019;15(4):259-268. doi: 10.2174/1573397115666190227194014. PMID: 30827250
Systemic sclerosis and its oral health implications.
Puzio A, Przywara-Chowaniec B, Postek-Stefańska L, Mrówka-Kata K, Trzaska K
Adv Clin Exp Med 2019 Apr;28(4):547-554. doi: 10.17219/acem/76847. PMID: 30079996
Sickle cell anemia.
Lonergan GJ, Cline DB, Abbondanzo SL
Radiographics 2001 Jul-Aug;21(4):971-94. doi: 10.1148/radiographics.21.4.g01jl23971. PMID: 11452073

Clinical prediction guides

Review of neuroimaging research progress of cerebral small vessel disease.
Wang J, Wang B, Wang K
Folia Neuropathol 2023;61(1):1-7. doi: 10.5114/fn.2023.124712. PMID: 37114955
Endothelial progenitor cells in the host defense response.
Shi X, Seidle KA, Simms KJ, Dong F, Chilian WM, Zhang P
Pharmacol Ther 2023 Jan;241:108315. Epub 2022 Nov 24 doi: 10.1016/j.pharmthera.2022.108315. PMID: 36436689Free PMC Article
Surgical Escharotomy and Decompressive Therapies in Burns.
Butts CC, Holmes JH, Carter JE
J Burn Care Res 2020 Feb 19;41(2):263-269. doi: 10.1093/jbcr/irz152. PMID: 31504609
Wake-up stroke: From pathophysiology to management.
Peter-Derex L, Derex L
Sleep Med Rev 2019 Dec;48:101212. Epub 2019 Sep 23 doi: 10.1016/j.smrv.2019.101212. PMID: 31600679
Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels.
Mertins P, Yang F, Liu T, Mani DR, Petyuk VA, Gillette MA, Clauser KR, Qiao JW, Gritsenko MA, Moore RJ, Levine DA, Townsend R, Erdmann-Gilmore P, Snider JE, Davies SR, Ruggles KV, Fenyo D, Kitchens RT, Li S, Olvera N, Dao F, Rodriguez H, Chan DW, Liebler D, White F, Rodland KD, Mills GB, Smith RD, Paulovich AG, Ellis M, Carr SA
Mol Cell Proteomics 2014 Jul;13(7):1690-704. Epub 2014 Apr 9 doi: 10.1074/mcp.M113.036392. PMID: 24719451Free PMC Article

Recent systematic reviews

Animal experimental models of ischemic limbs - A systematic review.
Lovasova V, Bem R, Chlupac J, Dubsky M, Husakova J, Nemcova A, Fronek J
Vascul Pharmacol 2023 Dec;153:107237. Epub 2023 Oct 5 doi: 10.1016/j.vph.2023.107237. PMID: 37802406
Acquired methemoglobinemia: A systematic review of reported cases.
Gao H, Basri R, Tran MH
Transfus Apher Sci 2022 Apr;61(2):103299. Epub 2021 Oct 27 doi: 10.1016/j.transci.2021.103299. PMID: 34740513
Role of vasopressin and terlipressin in refractory shock compared to conventional therapy in the neonatal and pediatric population: a systematic review, meta-analysis, and trial sequential analysis.
Masarwa R, Paret G, Perlman A, Reif S, Raccah BH, Matok I
Crit Care 2017 Jan 5;21(1):1. doi: 10.1186/s13054-016-1589-6. PMID: 28057037Free PMC Article
Experimental evaluation of clinical colon anastomotic leakage.
Pommergaard HC
Dan Med J 2014 Mar;61(3):B4821. PMID: 24814921
Vascular tissue engineering: from in vitro to in situ.
Li S, Sengupta D, Chien S
Wiley Interdiscip Rev Syst Biol Med 2014 Jan-Feb;6(1):61-76. Epub 2013 Oct 22 doi: 10.1002/wsbm.1246. PMID: 24151038

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