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Hypobilirubinemia

MedGen UID:
1780544
•Concept ID:
C5539630
•
Finding
HPO: HP:0033480

Definition

Concentration of bilirubin in the blood circulation below the lower limit of normal. [from HPO]

Recent clinical studies

Etiology

Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
Poynard T, Deckmyn O, Peta V, Sakka M, Lebray P, Moussalli J, Pais R, Housset C, Ratziu V, Pasmant E, Thabut D; FibroFrance Group
Hepatol Commun 2023 Oct 1;7(10) Epub 2023 Sep 22 doi: 10.1097/HC9.0000000000000245. PMID: 37738404Free PMC Article
Association between serum bilirubin and estimated glomerular filtration rate among elderly persons.
Kawamoto R, Ninomiya D, Hasegawa Y, Kasai Y, Kusunoki T, Ohtsuka N, Kumagi T
PLoS One 2014;9(12):e115294. Epub 2014 Dec 16 doi: 10.1371/journal.pone.0115294. PMID: 25514359Free PMC Article
Hypobilirubinemia might be a possible risk factor of end-stage kidney disease independently of estimated glomerular filtration rate.
Oda E, Aoyagi R, Aizawa Y
Kidney Blood Press Res 2012;36(1):47-54. Epub 2012 Jul 24 doi: 10.1159/000339027. PMID: 22832707
Low serum bilirubin concentrations are associated with impaired aortic elastic properties, but not impaired left ventricular diastolic function.
Caliskan M, Erdogan D, Gullu H, Tok D, Bilgi M, Muderrisoglu H
Int J Clin Pract 2007 Feb;61(2):218-24. doi: 10.1111/j.1742-1241.2006.00907.x. PMID: 21882369
High serum bilirubin concentrations preserve coronary flow reserve and coronary microvascular functions.
Gullu H, Erdogan D, Tok D, Topcu S, Caliskan M, Ulus T, Muderrisoglu H
Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2289-94. Epub 2005 Sep 8 doi: 10.1161/01.ATV.0000185806.61430.7c. PMID: 16151018

Diagnosis

Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
Poynard T, Deckmyn O, Peta V, Sakka M, Lebray P, Moussalli J, Pais R, Housset C, Ratziu V, Pasmant E, Thabut D; FibroFrance Group
Hepatol Commun 2023 Oct 1;7(10) Epub 2023 Sep 22 doi: 10.1097/HC9.0000000000000245. PMID: 37738404Free PMC Article
Hypobilirubinemia might be a possible risk factor of end-stage kidney disease independently of estimated glomerular filtration rate.
Oda E, Aoyagi R, Aizawa Y
Kidney Blood Press Res 2012;36(1):47-54. Epub 2012 Jul 24 doi: 10.1159/000339027. PMID: 22832707
Low serum bilirubin concentrations are associated with impaired aortic elastic properties, but not impaired left ventricular diastolic function.
Caliskan M, Erdogan D, Gullu H, Tok D, Bilgi M, Muderrisoglu H
Int J Clin Pract 2007 Feb;61(2):218-24. doi: 10.1111/j.1742-1241.2006.00907.x. PMID: 21882369
High serum bilirubin concentrations preserve coronary flow reserve and coronary microvascular functions.
Gullu H, Erdogan D, Tok D, Topcu S, Caliskan M, Ulus T, Muderrisoglu H
Arterioscler Thromb Vasc Biol 2005 Nov;25(11):2289-94. Epub 2005 Sep 8 doi: 10.1161/01.ATV.0000185806.61430.7c. PMID: 16151018

Therapy

Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia.
Poynard T, Deckmyn O, Peta V, Sakka M, Lebray P, Moussalli J, Pais R, Housset C, Ratziu V, Pasmant E, Thabut D; FibroFrance Group
Hepatol Commun 2023 Oct 1;7(10) Epub 2023 Sep 22 doi: 10.1097/HC9.0000000000000245. PMID: 37738404Free PMC Article
Hypobilirubinemia in patients with polychlorinated biphenyls poisoning.
Hirayama C, Okumura M, Nagai J, Masuda Y
Clin Chim Acta 1974 Aug 30;55(1):97-100. doi: 10.1016/0009-8981(74)90338-6. PMID: 4213154

Prognosis

Serum bilirubin: a simple routine surrogate marker of the progression of chronic kidney disease.
Moolchandani K, Priyadarssini M, Rajappa M, Parameswaran S, Revathy G
Br J Biomed Sci 2016 Oct;73(4):188-193. Epub 2016 May 27 doi: 10.1080/09674845.2016.1182674. PMID: 27231984
Hypobilirubinemia might be a possible risk factor of end-stage kidney disease independently of estimated glomerular filtration rate.
Oda E, Aoyagi R, Aizawa Y
Kidney Blood Press Res 2012;36(1):47-54. Epub 2012 Jul 24 doi: 10.1159/000339027. PMID: 22832707

Clinical prediction guides

Serum bilirubin: a simple routine surrogate marker of the progression of chronic kidney disease.
Moolchandani K, Priyadarssini M, Rajappa M, Parameswaran S, Revathy G
Br J Biomed Sci 2016 Oct;73(4):188-193. Epub 2016 May 27 doi: 10.1080/09674845.2016.1182674. PMID: 27231984
Hypobilirubinemia might be a possible risk factor of end-stage kidney disease independently of estimated glomerular filtration rate.
Oda E, Aoyagi R, Aizawa Y
Kidney Blood Press Res 2012;36(1):47-54. Epub 2012 Jul 24 doi: 10.1159/000339027. PMID: 22832707

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