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Fibrous crescent

MedGen UID:
1781176
•Concept ID:
C5539512
•
Finding
HPO: HP:0033319

Definition

A type of glomerular crescent characterized by extracapillary fibrosis composed of greater than 75% matrix and of less than 25% cells with or without fibrin, usually associated with disruption of Bowman's capsule and involving over 10% of the capsular circumference. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibrous crescent

Professional guidelines

PubMed

Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices.
Bajema IM, Wilhelmus S, Alpers CE, Bruijn JA, Colvin RB, Cook HT, D'Agati VD, Ferrario F, Haas M, Jennette JC, Joh K, Nast CC, Noël LH, Rijnink EC, Roberts ISD, Seshan SV, Sethi S, Fogo AB
Kidney Int 2018 Apr;93(4):789-796. Epub 2018 Feb 16 doi: 10.1016/j.kint.2017.11.023. PMID: 29459092
Methylprednisolone pulse therapy in the treatment of severe forms of Schönlein-Henoch purpura nephritis.
Niaudet P, Habib R
Pediatr Nephrol 1998 Apr;12(3):238-43. doi: 10.1007/s004670050446. PMID: 9630046
Treatment of severe IgA nephropathy in children.
Andreoli SP, Bergstein JM
Pediatr Nephrol 1989 Jul;3(3):248-53. doi: 10.1007/BF00858524. PMID: 2702102

Recent clinical studies

Etiology

Response to therapy at 6 months predicts long-term renal outcome in lupus nephritis with poor kidney function.
Luo H, Zhou Y, Chen G, Ren Q, Zhao J, Ye W, Qin Y, Li X
Lupus Sci Med 2022 Dec;9(1) doi: 10.1136/lupus-2022-000773. PMID: 36581380Free PMC Article
Relationship between Renal Damage and Serum Complement C3 in Children with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
Zhang P, Yang X, He X, Hu J, Gao CL, Xia ZK
Nephron 2021;145(6):633-641. Epub 2021 Jul 1 doi: 10.1159/000516533. PMID: 34198299
Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.
Tan M, Fang J, Xu Q, Zhang C, Zou G, Wang M, Li W
Ren Fail 2019 Nov;41(1):875-882. doi: 10.1080/0886022X.2019.1654512. PMID: 31517550Free PMC Article
Pathological severity determines the renal recovery for anti-myeloperoxidase antibody-associated vasculitis requiring dialysis at disease onset: a retrospective study.
Xu PC, Chen T, Wu SJ, Yang X, Gao S, Hu SY, Wei L, Yan TK
BMC Nephrol 2019 Jul 30;20(1):287. doi: 10.1186/s12882-019-1487-7. PMID: 31362703Free PMC Article
The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study.
Handa T, Kakita H, Tateishi Y, Endo T, Suzuki H, Katayama T, Tsukamoto T, Muso E
Clin Exp Nephrol 2018 Oct;22(5):1116-1127. Epub 2018 Mar 21 doi: 10.1007/s10157-018-1564-4. PMID: 29564665

Diagnosis

Clinicopathological characteristics and outcomes of anti-neutrophil cytoplasmic autoantibody-related renal vasculitis with hyperuricemia: a retrospective case-control study.
Wang R, An D, Wu Y, Ma P, Guo Y, Tang L
Sci Rep 2021 Jan 21;11(1):2002. doi: 10.1038/s41598-021-81664-z. PMID: 33479426Free PMC Article
Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.
Tan M, Fang J, Xu Q, Zhang C, Zou G, Wang M, Li W
Ren Fail 2019 Nov;41(1):875-882. doi: 10.1080/0886022X.2019.1654512. PMID: 31517550Free PMC Article
Pathological severity determines the renal recovery for anti-myeloperoxidase antibody-associated vasculitis requiring dialysis at disease onset: a retrospective study.
Xu PC, Chen T, Wu SJ, Yang X, Gao S, Hu SY, Wei L, Yan TK
BMC Nephrol 2019 Jul 30;20(1):287. doi: 10.1186/s12882-019-1487-7. PMID: 31362703Free PMC Article
Analysis of clinicopathologic correlations in Iranian patients with lupus nephritis.
Shariati-Sarabi Z, Ranjbar A, Monzavi SM, Esmaily H, Farzadnia M, Zeraati AA
Int J Rheum Dis 2013 Dec;16(6):731-8. Epub 2013 May 28 doi: 10.1111/1756-185X.12059. PMID: 24382282
Crescentic glomerulonephritis developing 3 months after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.
Takeuchi M, Tamaoki A, Tada A, Jyo Y, Nomura S, Takahashi K, Ohsawa G, Kibata M
Bone Marrow Transplant 1998 Oct;22(7):725-7. doi: 10.1038/sj.bmt.1701410. PMID: 9818704

Therapy

Successful Management of Lupus Nephritis with High Titers of Myeloperoxidase Anti-Neutrophil Cytoplasmic Antibodies Using Tacrolimus.
Abe Y, Shima T, Izumi Y, Kitamura M, Yamashita H, Tsuji Y, Sasaki O, Maeda C, Kawahara C, Torisu A, Kawaguchi Y, Kurohama H, Ito M, Iwanaga N, Kawakami A, Nakayama T, Taguchi T, Migita K
Intern Med 2015;54(22):2929-33. Epub 2015 Nov 15 doi: 10.2169/internalmedicine.54.4343. PMID: 26568012
Crescentic glomerulonephritis developing 3 months after autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.
Takeuchi M, Tamaoki A, Tada A, Jyo Y, Nomura S, Takahashi K, Ohsawa G, Kibata M
Bone Marrow Transplant 1998 Oct;22(7):725-7. doi: 10.1038/sj.bmt.1701410. PMID: 9818704

Prognosis

Risk Factors and Clinical Outcomes of Renal Thrombotic Microangiopathy in Children with Lupus Nephritis in Terms of Pathological and Clinical Features.
Zhang P, Yang X, Fu MZ, Gao CL, Fang X, Xia ZK
Nephron 2024;148(9):609-617. Epub 2024 Jun 7 doi: 10.1159/000538240. PMID: 38852577
Relationship between Renal Damage and Serum Complement C3 in Children with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.
Zhang P, Yang X, He X, Hu J, Gao CL, Xia ZK
Nephron 2021;145(6):633-641. Epub 2021 Jul 1 doi: 10.1159/000516533. PMID: 34198299
Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.
Tan M, Fang J, Xu Q, Zhang C, Zou G, Wang M, Li W
Ren Fail 2019 Nov;41(1):875-882. doi: 10.1080/0886022X.2019.1654512. PMID: 31517550Free PMC Article
The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study.
Handa T, Kakita H, Tateishi Y, Endo T, Suzuki H, Katayama T, Tsukamoto T, Muso E
Clin Exp Nephrol 2018 Oct;22(5):1116-1127. Epub 2018 Mar 21 doi: 10.1007/s10157-018-1564-4. PMID: 29564665
End-stage renal failure due to crescentic glomerulonephritis in a patient with Behçet's syndrome. Review of the literature.
Sakemi T, Yoshiyuki T, Ikeda Y, Suzuki N, Nagasawa K
Am J Nephrol 1998;18(4):321-4. doi: 10.1159/000013358. PMID: 9653837

Clinical prediction guides

Risk Factors and Clinical Outcomes of Renal Thrombotic Microangiopathy in Children with Lupus Nephritis in Terms of Pathological and Clinical Features.
Zhang P, Yang X, Fu MZ, Gao CL, Fang X, Xia ZK
Nephron 2024;148(9):609-617. Epub 2024 Jun 7 doi: 10.1159/000538240. PMID: 38852577
Response to therapy at 6 months predicts long-term renal outcome in lupus nephritis with poor kidney function.
Luo H, Zhou Y, Chen G, Ren Q, Zhao J, Ye W, Qin Y, Li X
Lupus Sci Med 2022 Dec;9(1) doi: 10.1136/lupus-2022-000773. PMID: 36581380Free PMC Article
Outcomes of normotensive IgA nephropathy patients with mild proteinuria who have impaired renal function.
Tan M, Fang J, Xu Q, Zhang C, Zou G, Wang M, Li W
Ren Fail 2019 Nov;41(1):875-882. doi: 10.1080/0886022X.2019.1654512. PMID: 31517550Free PMC Article
Analysis of clinicopathologic correlations in Iranian patients with lupus nephritis.
Shariati-Sarabi Z, Ranjbar A, Monzavi SM, Esmaily H, Farzadnia M, Zeraati AA
Int J Rheum Dis 2013 Dec;16(6):731-8. Epub 2013 May 28 doi: 10.1111/1756-185X.12059. PMID: 24382282
Immunofluorescent studies on alpha 2-plasmin inhibitor (alpha 2-PI) in glomeruli from patients with IgA nephropathy.
Miura M, Tomino Y, Yagame M, Endoh M, Suga T, Nomoto Y, Sakai H
Clin Exp Immunol 1985 Nov;62(2):380-6. PMID: 2935337Free PMC Article

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