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Primary obstructive megaureter

MedGen UID:
1781352
•Concept ID:
C5539884
•
Anatomical Abnormality
HPO: HP:4000035

Definition

Megaurater associated with obstruction or an adynamic ureteral segment in the ureterovesical junction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary obstructive megaureter

Professional guidelines

PubMed

Re. 'BAPU consensus statement on the management of the primary obstructive megaureter'.
Chedgy EC
J Pediatr Urol 2014 Aug;10(4):787. Epub 2014 May 9 doi: 10.1016/j.jpurol.2014.03.009. PMID: 24857285
British Association of Paediatric Urologists consensus statement on the management of the primary obstructive megaureter.
Farrugia MK, Hitchcock R, Radford A, Burki T, Robb A, Murphy F; British Association of Paediatric Urologists
J Pediatr Urol 2014 Feb;10(1):26-33. Epub 2013 Oct 16 doi: 10.1016/j.jpurol.2013.09.018. PMID: 24206785
Endoureterotomy for treatment of primary obstructive megaureter in children.
Kajbafzadeh AM, Payabvash S, Salmasi AH, Arshadi H, Hashemi SM, Arabian S, Najjaran-Tousi V
J Endourol 2007 Jul;21(7):743-9. doi: 10.1089/end.2006.0330. PMID: 17705763

Recent clinical studies

Etiology

Endoscopic treatment of primary obstructive megaureter with high pressure balloon dilation in infants.
Boswell TC, Davis-Dao CA, Williamson SH, Chamberlin JD, Nguyen T, Chuang KW, Stephany HA, Wehbi EJ, Khoury AE
J Pediatr Urol 2024 Feb;20(1):67-74. Epub 2023 Sep 16 doi: 10.1016/j.jpurol.2023.09.007. PMID: 37783596
Spontaneous resolution and the role of endoscopic surgery in the treatment of primary obstructive megaureter: a review of the literature.
Isac GV, Danila GM, Ionescu SN
Pediatr Med Chir 2023 Dec 19;45(2) doi: 10.4081/pmc.2023.327. PMID: 38112615
Endoscopic balloon dilation of primary obstructive megaureter: is fluoroscopic guidance necessary?
Ortiz R, Burgos L, Fernández-Bautista B, Parente A, Ordóñez J, Angulo JM
World J Urol 2023 Oct;41(10):2861-2867. Epub 2023 Sep 10 doi: 10.1007/s00345-023-04572-z. PMID: 37690062
Laparoscopic Extravesical Reimplantation in Children with Primary Obstructive Megaureter.
Lopez M, Perez-Etchepare E, Bustangi N, Godik O, Juricic M, Varlet F, Gutierrez R, Gomez Culebras M, Gander R, Royo G, Asensio M
J Laparoendosc Adv Surg Tech A 2023 Jul;33(7):713-718. Epub 2020 Mar 26 doi: 10.1089/lap.2019.0396. PMID: 32212997
Endoscopic management of primary obstructive megaureter in pediatrics.
Teklali Y, Robert Y, Boillot B, Overs C, Piolat C, Rabattu PY
J Pediatr Urol 2018 Oct;14(5):382-387. Epub 2018 Jun 28 doi: 10.1016/j.jpurol.2018.05.027. PMID: 30006257

Diagnosis

Endoscopic treatment of primary obstructive megaureter with high pressure balloon dilation in infants.
Boswell TC, Davis-Dao CA, Williamson SH, Chamberlin JD, Nguyen T, Chuang KW, Stephany HA, Wehbi EJ, Khoury AE
J Pediatr Urol 2024 Feb;20(1):67-74. Epub 2023 Sep 16 doi: 10.1016/j.jpurol.2023.09.007. PMID: 37783596
Spontaneous resolution and the role of endoscopic surgery in the treatment of primary obstructive megaureter: a review of the literature.
Isac GV, Danila GM, Ionescu SN
Pediatr Med Chir 2023 Dec 19;45(2) doi: 10.4081/pmc.2023.327. PMID: 38112615
Laparoscopic Extravesical Reimplantation in Children with Primary Obstructive Megaureter.
Lopez M, Perez-Etchepare E, Bustangi N, Godik O, Juricic M, Varlet F, Gutierrez R, Gomez Culebras M, Gander R, Royo G, Asensio M
J Laparoendosc Adv Surg Tech A 2023 Jul;33(7):713-718. Epub 2020 Mar 26 doi: 10.1089/lap.2019.0396. PMID: 32212997
Endoscopic balloon dilatation in primary obstructive megaureter: Long-term results.
Casal Beloy I, Somoza Argibay I, García González M, García Novoa MA, Míguez Fortes LM, Dargallo Carbonell T
J Pediatr Urol 2018 Apr;14(2):167.e1-167.e5. Epub 2017 Nov 21 doi: 10.1016/j.jpurol.2017.10.016. PMID: 29398584
Megaureter.
Manzoni C
Rays 2002 Apr-Jun;27(2):83-5. PMID: 12696257

Therapy

Endoscopic dilatation/incision of primary obstructive megaureter. A systematic review. On behalf of the EAU paediatric urology guidelines panel.
Skott M, Gnech M, Hoen LA', Kennedy U, Van Uitert A, Zachou A, Yuan Y, Quaedackers J, Silay MS, Rawashdeh YF, Burgu B, Castagnetti M, O'Kelly F, Bogaert G, Radmayr C
J Pediatr Urol 2024 Feb;20(1):47-56. Epub 2023 Sep 13 doi: 10.1016/j.jpurol.2023.09.005. PMID: 37758534
Endoscopic balloon dilation of primary obstructive megaureter: is fluoroscopic guidance necessary?
Ortiz R, Burgos L, Fernández-Bautista B, Parente A, Ordóñez J, Angulo JM
World J Urol 2023 Oct;41(10):2861-2867. Epub 2023 Sep 10 doi: 10.1007/s00345-023-04572-z. PMID: 37690062
Laparoscopic Extravesical Reimplantation in Children with Primary Obstructive Megaureter.
Lopez M, Perez-Etchepare E, Bustangi N, Godik O, Juricic M, Varlet F, Gutierrez R, Gomez Culebras M, Gander R, Royo G, Asensio M
J Laparoendosc Adv Surg Tech A 2023 Jul;33(7):713-718. Epub 2020 Mar 26 doi: 10.1089/lap.2019.0396. PMID: 32212997
Postoperative JJ stent is not necessary after balloon high-pressure endoscopic dilatation of primary obstructive megaureter.
Faraj S, Loubersac T, Graveleau A, Alliot H, Camby C, Leclair MD
J Pediatr Urol 2022 Jun;18(3):369.e1-369.e7. Epub 2022 Apr 13 doi: 10.1016/j.jpurol.2022.03.028. PMID: 35562267
Endoscopic management of primary obstructive megaureter in pediatrics.
Teklali Y, Robert Y, Boillot B, Overs C, Piolat C, Rabattu PY
J Pediatr Urol 2018 Oct;14(5):382-387. Epub 2018 Jun 28 doi: 10.1016/j.jpurol.2018.05.027. PMID: 30006257

Prognosis

Spontaneous resolution and the role of endoscopic surgery in the treatment of primary obstructive megaureter: a review of the literature.
Isac GV, Danila GM, Ionescu SN
Pediatr Med Chir 2023 Dec 19;45(2) doi: 10.4081/pmc.2023.327. PMID: 38112615
Endoscopic balloon dilatation of primary obstructive megaureter: method standardization and predictive prognostic factors.
Chiarenza SF, Bleve C, Zolpi E, Battaglino F, Fasoli L, Bucci V
Pediatr Med Chir 2019 Dec 23;41(2) doi: 10.4081/pmc.2019.219. PMID: 31867939
Long-term outcome of JJ stent insertion for primary obstructive megaureter in children.
Awad K, Woodward MN, Shalaby MS
J Pediatr Urol 2019 Feb;15(1):66.e1-66.e5. Epub 2018 Oct 5 doi: 10.1016/j.jpurol.2018.09.011. PMID: 30385050
Endoscopic balloon dilatation in primary obstructive megaureter: Long-term results.
Casal Beloy I, Somoza Argibay I, García González M, García Novoa MA, Míguez Fortes LM, Dargallo Carbonell T
J Pediatr Urol 2018 Apr;14(2):167.e1-167.e5. Epub 2017 Nov 21 doi: 10.1016/j.jpurol.2017.10.016. PMID: 29398584
Primary obstructive megaureter in children.
Hanna MK, Jeffs RD
Urology 1975 Oct;6(4):419-27. doi: 10.1016/0090-4295(75)90620-2. PMID: 1179558

Clinical prediction guides

Advancements in Surgical Management of Megaureters.
Boswell TC
Curr Urol Rep 2024 Sep;25(9):215-223. Epub 2024 Jul 2 doi: 10.1007/s11934-024-01214-8. PMID: 38954357Free PMC Article
Downregulation of fibrosis related hsa-miR-29c-3p in human CAKUT.
Macak N, Jovanovic I, Zivkovic M, Mitrovic K, Cvetkovic M, Kostic M, Stankovic A
Nucleosides Nucleotides Nucleic Acids 2023;42(12):945-958. Epub 2023 Jun 8 doi: 10.1080/15257770.2023.2218430. PMID: 37291879
Ureteral Reimplantation for Primary Obstructive Megaureter in Pediatric Patients: Is It Time for Robot-Assisted Approach?
Sforza S, Cini C, Negri E, Bortot G, Di Maida F, Cito G, Escolino M, Esposito C, Minervini A, Masieri L
J Laparoendosc Adv Surg Tech A 2022 Feb;32(2):231-236. Epub 2021 Dec 14 doi: 10.1089/lap.2021.0246. PMID: 34905408
Endoscopic balloon dilatation in primary obstructive megaureter: Long-term results.
Casal Beloy I, Somoza Argibay I, García González M, García Novoa MA, Míguez Fortes LM, Dargallo Carbonell T
J Pediatr Urol 2018 Apr;14(2):167.e1-167.e5. Epub 2017 Nov 21 doi: 10.1016/j.jpurol.2017.10.016. PMID: 29398584
Primary obstructive megaureter: cutting balloon endo-ureterotomy.
Smeulders N, Yankovic F, Chippington S, Cherian A
J Pediatr Urol 2013 Oct;9(5):692.e1-2. Epub 2013 Jun 5 doi: 10.1016/j.jpurol.2013.04.010. PMID: 23759477

Recent systematic reviews

Endoscopic dilatation/incision of primary obstructive megaureter. A systematic review. On behalf of the EAU paediatric urology guidelines panel.
Skott M, Gnech M, Hoen LA', Kennedy U, Van Uitert A, Zachou A, Yuan Y, Quaedackers J, Silay MS, Rawashdeh YF, Burgu B, Castagnetti M, O'Kelly F, Bogaert G, Radmayr C
J Pediatr Urol 2024 Feb;20(1):47-56. Epub 2023 Sep 13 doi: 10.1016/j.jpurol.2023.09.005. PMID: 37758534
High-pressure balloon dilatation of primary obstructive megaureter in children: a systematic review.
Ripatti L, Viljamaa HR, Suihko A, Pakkasjärvi N
BMC Urol 2023 Mar 3;23(1):30. doi: 10.1186/s12894-023-01199-5. PMID: 36869342Free PMC Article
Endoscopic Management of Primary Obstructive Megaureter: A Systematic Review.
Doudt AD, Pusateri CR, Christman MS
J Endourol 2018 Jun;32(6):482-487. doi: 10.1089/end.2017.0434. PMID: 29676162

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