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Vascular Depression

MedGen UID:
1781943
•Concept ID:
C5544381
•
Disease or Syndrome
Synonyms: Depression, Subcortical Ischemic; Depression, Vascular; Subcortical Ischemic Depression

Definition

Late-life depression associated with clinical or MRI defined cerebrovascular pathology. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVascular Depression

Professional guidelines

PubMed

Mechanisms and treatment of late-life depression.
Alexopoulos GS
Transl Psychiatry 2019 Aug 5;9(1):188. doi: 10.1038/s41398-019-0514-6. PMID: 31383842Free PMC Article
Late-life depression: evidence-based treatment and promising new directions for research and clinical practice.
Andreescu C, Reynolds CF 3rd
Psychiatr Clin North Am 2011 Jun;34(2):335-55, vii-iii. doi: 10.1016/j.psc.2011.02.005. PMID: 21536162Free PMC Article
Establishing diagnostic criteria for vascular depression.
Steffens DC
J Neurol Sci 2004 Nov 15;226(1-2):59-62. doi: 10.1016/j.jns.2004.09.013. PMID: 15537521

Recent clinical studies

Etiology

Mechanisms and treatment of late-life depression.
Alexopoulos GS
Transl Psychiatry 2019 Aug 5;9(1):188. doi: 10.1038/s41398-019-0514-6. PMID: 31383842Free PMC Article
Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms.
Kerner NA, Roose SP
Am J Geriatr Psychiatry 2016 Jun;24(6):496-508. Epub 2016 Apr 29 doi: 10.1016/j.jagp.2016.01.134. PMID: 27139243Free PMC Article
Depression in cognitive impairment.
Pellegrino LD, Peters ME, Lyketsos CG, Marano CM
Curr Psychiatry Rep 2013 Sep;15(9):384. doi: 10.1007/s11920-013-0384-1. PMID: 23933974Free PMC Article
Vascular factors and depression.
Teper E, O'Brien JT
Int J Geriatr Psychiatry 2008 Oct;23(10):993-1000. doi: 10.1002/gps.2020. PMID: 18449953
'Vascular depression' hypothesis.
Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M
Arch Gen Psychiatry 1997 Oct;54(10):915-22. doi: 10.1001/archpsyc.1997.01830220033006. PMID: 9337771

Diagnosis

Vascular Depression and Cognition in Mexican Americans.
Johnson LA, Large SE, Izurieta Munoz H, Hall JR, O'Bryant SE
Dement Geriatr Cogn Disord 2019;47(1-2):68-78. Epub 2019 Mar 12 doi: 10.1159/000494272. PMID: 30861514
Vascular depression and the death of Queen Victoria.
Abrams RC, Alexopoulos GS
Int J Geriatr Psychiatry 2018 Dec;33(12):1556-1561. Epub 2018 Oct 1 doi: 10.1002/gps.4984. PMID: 30276875
Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms.
Kerner NA, Roose SP
Am J Geriatr Psychiatry 2016 Jun;24(6):496-508. Epub 2016 Apr 29 doi: 10.1016/j.jagp.2016.01.134. PMID: 27139243Free PMC Article
Depression in cognitive impairment.
Pellegrino LD, Peters ME, Lyketsos CG, Marano CM
Curr Psychiatry Rep 2013 Sep;15(9):384. doi: 10.1007/s11920-013-0384-1. PMID: 23933974Free PMC Article
MRI-defined vascular depression.
Krishnan KR, Hays JC, Blazer DG
Am J Psychiatry 1997 Apr;154(4):497-501. doi: 10.1176/ajp.154.4.497. PMID: 9090336

Therapy

The enigma of vascular depression in old age: a critical update.
Jellinger KA
J Neural Transm (Vienna) 2022 Aug;129(8):961-976. Epub 2022 Jun 15 doi: 10.1007/s00702-022-02521-5. PMID: 35705878
Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms.
Kerner NA, Roose SP
Am J Geriatr Psychiatry 2016 Jun;24(6):496-508. Epub 2016 Apr 29 doi: 10.1016/j.jagp.2016.01.134. PMID: 27139243Free PMC Article
Depression in cognitive impairment.
Pellegrino LD, Peters ME, Lyketsos CG, Marano CM
Curr Psychiatry Rep 2013 Sep;15(9):384. doi: 10.1007/s11920-013-0384-1. PMID: 23933974Free PMC Article
Vascular depression: where do we go from here?
Naarding P, Beekman AT
Expert Rev Neurother 2011 Jan;11(1):77-83. doi: 10.1586/ern.10.92. PMID: 21158557
'Vascular depression' hypothesis.
Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M
Arch Gen Psychiatry 1997 Oct;54(10):915-22. doi: 10.1001/archpsyc.1997.01830220033006. PMID: 9337771

Prognosis

The enigma of vascular depression in old age: a critical update.
Jellinger KA
J Neural Transm (Vienna) 2022 Aug;129(8):961-976. Epub 2022 Jun 15 doi: 10.1007/s00702-022-02521-5. PMID: 35705878
Pathomechanisms of Vascular Depression in Older Adults.
Jellinger KA
Int J Mol Sci 2021 Dec 28;23(1) doi: 10.3390/ijms23010308. PMID: 35008732Free PMC Article
Vascular Depression and Cognition in Mexican Americans.
Johnson LA, Large SE, Izurieta Munoz H, Hall JR, O'Bryant SE
Dement Geriatr Cogn Disord 2019;47(1-2):68-78. Epub 2019 Mar 12 doi: 10.1159/000494272. PMID: 30861514
The vascular depression hypothesis: mechanisms linking vascular disease with depression.
Taylor WD, Aizenstein HJ, Alexopoulos GS
Mol Psychiatry 2013 Sep;18(9):963-74. Epub 2013 Feb 26 doi: 10.1038/mp.2013.20. PMID: 23439482Free PMC Article
Vascular depression: where do we go from here?
Naarding P, Beekman AT
Expert Rev Neurother 2011 Jan;11(1):77-83. doi: 10.1586/ern.10.92. PMID: 21158557

Clinical prediction guides

The enigma of vascular depression in old age: a critical update.
Jellinger KA
J Neural Transm (Vienna) 2022 Aug;129(8):961-976. Epub 2022 Jun 15 doi: 10.1007/s00702-022-02521-5. PMID: 35705878
Pathomechanisms of Vascular Depression in Older Adults.
Jellinger KA
Int J Mol Sci 2021 Dec 28;23(1) doi: 10.3390/ijms23010308. PMID: 35008732Free PMC Article
Vascular Depression and Cognition in Mexican Americans.
Johnson LA, Large SE, Izurieta Munoz H, Hall JR, O'Bryant SE
Dement Geriatr Cogn Disord 2019;47(1-2):68-78. Epub 2019 Mar 12 doi: 10.1159/000494272. PMID: 30861514
The vascular depression hypothesis: mechanisms linking vascular disease with depression.
Taylor WD, Aizenstein HJ, Alexopoulos GS
Mol Psychiatry 2013 Sep;18(9):963-74. Epub 2013 Feb 26 doi: 10.1038/mp.2013.20. PMID: 23439482Free PMC Article
Depression and dementia.
Korczyn AD, Halperin I
J Neurol Sci 2009 Aug 15;283(1-2):139-42. Epub 2009 Apr 5 doi: 10.1016/j.jns.2009.02.346. PMID: 19345960

Recent systematic reviews

Vascular depression in Black Americans: A systematic review of the construct and its cognitive, functional, and psychosocial correlates.
Bogoian HR, Dotson VM
Clin Neuropsychol 2022 Feb;36(2):431-461. Epub 2021 Jun 7 doi: 10.1080/13854046.2021.1933188. PMID: 34098846Free PMC Article
Repetitive Transcranial Magnetic Stimulation for Depression Due to Cerebrovascular Disease: A Systematic Review.
McIntyre A, Thompson S, Burhan A, Mehta S, Teasell R
J Stroke Cerebrovasc Dis 2016 Dec;25(12):2792-2800. Epub 2016 Oct 12 doi: 10.1016/j.jstrokecerebrovasdis.2016.08.043. PMID: 27743927
Therapeutic interventions for vascular depression: a systematic review.
Brunoni AR, Benseñor IM, Alves TC
Braz J Psychiatry 2011 Dec;33(4):400-9. doi: 10.1590/s1516-44462011000400015. PMID: 22189931
Geriatric depression and vascular diseases: what are the links?
Camus V, Kraehenbühl H, Preisig M, Büla CJ, Waeber G
J Affect Disord 2004 Jul;81(1):1-16. doi: 10.1016/j.jad.2003.08.003. PMID: 15183594
Depression and vascular disease: what is the relationship?
Thomas AJ, Kalaria RN, O'Brien JT
J Affect Disord 2004 Apr;79(1-3):81-95. doi: 10.1016/S0165-0327(02)00349-X. PMID: 15023483

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