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Migratory erythematous plaque

MedGen UID:
1782116
•Concept ID:
C5539726
•
Disease or Syndrome
HPO: HP:0033622

Definition

A migratory, centrifugal, erythematous, tender, non-purpuric, and well-demarcated plaque. This feature may be observed in TNF receptor-associated periodic syndrome, in which it often occurs together with migratory myalgia in muscles located underneath the affected areas of skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMigratory erythematous plaque

Professional guidelines

PubMed

Role of etanercept in the treatment of tumor necrosis factor receptor-associated periodic syndrome: personal experience and review of the literature.
Cantarini L, Rigante D, Lucherini OM, Cimaz R, Laghi Pasini F, Baldari CT, Benucci M, Simonini G, Di Sabatino V, Brizi MG, Galeazzi M
Int J Immunopathol Pharmacol 2010 Jul-Sep;23(3):701-7. doi: 10.1177/039463201002300303. PMID: 20943039

Recent clinical studies

Etiology

Clinical variability of the GJB4:c.35G > A gene variant: a study of a large Brazilian erythrokeratodermia pedigree.
de Oliveira RTG, Christofolini DM, Criado PR, Lacaz Martins E, Kelsell D, Machado Filho CDS
Int J Dermatol 2020 Jun;59(6):722-725. Epub 2020 Apr 20 doi: 10.1111/ijd.14894. PMID: 32311086
A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Cutaneous gnathostomiasis: report of 6 cases with emphasis on histopathological demonstration of the larva.
Laga AC, Lezcano C, Ramos C, Costa H, Chian C, Salinas C, Salomon M, del Solar M, Bravo F
J Am Acad Dermatol 2013 Feb;68(2):301-5. Epub 2012 Aug 30 doi: 10.1016/j.jaad.2012.07.016. PMID: 22940406
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
A case of erythrokeratoderma variabilis without mutations in connexin 31.
Ishida-Yamamoto A, Kelsell D, Common J, Houseman MJ, Hashimoto M, Shibaki H, Asano K, Takahashi H, Hashimoto Y, Senshu T, Leigh IM, Iizuka H
Br J Dermatol 2000 Dec;143(6):1283-7. doi: 10.1046/j.1365-2133.2000.03902.x. PMID: 11122035

Diagnosis

A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Necrolytic migratory erythema and pancreatic glucagonoma.
Rodríguez G, Vargas E, Abaúnza C, Cáceres S
Biomedica 2016 Jun 3;36(2):176-81. doi: 10.7705/biomedica.v36i3.2723. PMID: 27622478
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
Granuloma annulare.
Gupta D, Hess B, Bachegowda L
ScientificWorldJournal 2010 Mar 5;10:384-6. doi: 10.1100/tsw.2010.51. PMID: 20209383Free PMC Article
Erythema nodosum.
Requena L, Requena C
Dermatol Online J 2002 Jun;8(1):4. PMID: 12165214

Therapy

Highly suspected valsartan-induced chronic erythema nodosum migrans in a patient with hypertension: a case report.
Liu Y, Guan Y, Liu H, Bian Q
J Int Med Res 2022 Feb;50(2):3000605221079553. doi: 10.1177/03000605221079553. PMID: 35176888Free PMC Article
Recurrent episodes of palpable migratory arciform erythema associated with IVIg infusions.
Johnson N, Rush P, Holliday A
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999580
A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Necrolytic acral erythema.
Patel U, Loyd A, Patel R, Meehan S, Kundu R
Dermatol Online J 2010 Nov 15;16(11):15. PMID: 21163166
Role of etanercept in the treatment of tumor necrosis factor receptor-associated periodic syndrome: personal experience and review of the literature.
Cantarini L, Rigante D, Lucherini OM, Cimaz R, Laghi Pasini F, Baldari CT, Benucci M, Simonini G, Di Sabatino V, Brizi MG, Galeazzi M
Int J Immunopathol Pharmacol 2010 Jul-Sep;23(3):701-7. doi: 10.1177/039463201002300303. PMID: 20943039

Prognosis

Expanding the clinical phenotype associated with NIPAL4 mutation: Study of a Tunisian consanguineous family with erythrokeratodermia variabilis-Like Autosomal Recessive Congenital Ichthyosis.
Charfeddine C, Laroussi N, Mkaouar R, Jouini R, Khayat O, Redissi A, Mosbah A, Dallali H, Chedly Debbiche A, Zaouak A, Fenniche S, Abdelhak S, Hammami-Ghorbel H
PLoS One 2021;16(10):e0258777. Epub 2021 Oct 20 doi: 10.1371/journal.pone.0258777. PMID: 34669720Free PMC Article
Recurrent episodes of palpable migratory arciform erythema associated with IVIg infusions.
Johnson N, Rush P, Holliday A
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999580
A review of cutaneous manifestations within glucagonoma syndrome: necrolytic migratory erythema.
Tolliver S, Graham J, Kaffenberger BH
Int J Dermatol 2018 Jun;57(6):642-645. Epub 2018 Feb 16 doi: 10.1111/ijd.13947. PMID: 29450880
Possibly drug-induced palpable migratory arciform erythema.
Dantas FL, Valente NY, Veronez IS, Kakizaki P, Leitão JR, Fraga RC
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):77-80. doi: 10.1590/abd1806-4841.20153624. PMID: 26312680Free PMC Article
Erythema nodosum.
Requena L, Requena C
Dermatol Online J 2002 Jun;8(1):4. PMID: 12165214

Clinical prediction guides

Expanding the clinical phenotype associated with NIPAL4 mutation: Study of a Tunisian consanguineous family with erythrokeratodermia variabilis-Like Autosomal Recessive Congenital Ichthyosis.
Charfeddine C, Laroussi N, Mkaouar R, Jouini R, Khayat O, Redissi A, Mosbah A, Dallali H, Chedly Debbiche A, Zaouak A, Fenniche S, Abdelhak S, Hammami-Ghorbel H
PLoS One 2021;16(10):e0258777. Epub 2021 Oct 20 doi: 10.1371/journal.pone.0258777. PMID: 34669720Free PMC Article
Recurrent episodes of palpable migratory arciform erythema associated with IVIg infusions.
Johnson N, Rush P, Holliday A
Dermatol Online J 2021 Apr 15;27(4) PMID: 33999580
Clinical variability of the GJB4:c.35G > A gene variant: a study of a large Brazilian erythrokeratodermia pedigree.
de Oliveira RTG, Christofolini DM, Criado PR, Lacaz Martins E, Kelsell D, Machado Filho CDS
Int J Dermatol 2020 Jun;59(6):722-725. Epub 2020 Apr 20 doi: 10.1111/ijd.14894. PMID: 32311086
Epidermolytic hyperkeratosis with polycyclic psoriasiform plaques resulting from a mutation in the keratin 1 gene.
Michael EJ, Schneiderman P, Grossman ME, Christiano AM
Exp Dermatol 1999 Dec;8(6):501-3. doi: 10.1111/j.1600-0625.1999.tb00309.x. PMID: 10597140

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