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del(9p21)

MedGen UID:
1782704
•Concept ID:
C5447684
•
Cell or Molecular Dysfunction

Definition

A cytogenic abnormality that refers to any loss of genetic material from the short arm of chromosome 9 that includes the band at 9p21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVdel(9p21)

Recent clinical studies

Etiology

ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL): The spectrum of clonal heterogeneity and its impact on prognosis.
Ampatzidou M, Papadhimitriou SI, Paterakis G, Pavlidis D, Tsitsikas Κ, Kostopoulos IV, Papadakis V, Vassilopoulos G, Polychronopoulou S
Cancer Genet 2018 Aug;224-225:1-11. Epub 2018 Mar 27 doi: 10.1016/j.cancergen.2018.03.001. PMID: 29778230
Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomodulatory agents response: redefining high-risk multiple myeloma in Asian patients.
Byun JM, Shin DY, Hong J, Kim I, Kim HK, Lee DS, Koh Y, Yoon SS
Cancer Med 2018 Mar;7(3):831-841. Epub 2018 Jan 29 doi: 10.1002/cam4.1340. PMID: 29380550Free PMC Article
Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia.
Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J
Int J Clin Exp Pathol 2015;8(6):7494-8. Epub 2015 Jun 1 PMID: 26261659Free PMC Article
Genomic imbalances in T-cell acute lymphoblastic leukemia cell lines.
Gebhart E, Thoma K, Verdorfer I, Drexler HG, Efferth T
Int J Oncol 2002 Oct;21(4):887-94. PMID: 12239631

Diagnosis

Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomodulatory agents response: redefining high-risk multiple myeloma in Asian patients.
Byun JM, Shin DY, Hong J, Kim I, Kim HK, Lee DS, Koh Y, Yoon SS
Cancer Med 2018 Mar;7(3):831-841. Epub 2018 Jan 29 doi: 10.1002/cam4.1340. PMID: 29380550Free PMC Article
Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia.
Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J
Int J Clin Exp Pathol 2015;8(6):7494-8. Epub 2015 Jun 1 PMID: 26261659Free PMC Article
Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics.
Primo D, Tabernero MD, Perez JJ, Rasillo A, Sayagués JM, Espinosa AB, Lopez-Berges MC, García-Sanz R, Gutierrez NC, Hernandez JM, Romero M, Osuna CS, Giralt M, Barbon M, San Miguel JF, Orfao A
Leukemia 2005 May;19(5):713-20. doi: 10.1038/sj.leu.2403714. PMID: 15789066
Genomic imbalances in T-cell acute lymphoblastic leukemia cell lines.
Gebhart E, Thoma K, Verdorfer I, Drexler HG, Efferth T
Int J Oncol 2002 Oct;21(4):887-94. PMID: 12239631

Therapy

Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomodulatory agents response: redefining high-risk multiple myeloma in Asian patients.
Byun JM, Shin DY, Hong J, Kim I, Kim HK, Lee DS, Koh Y, Yoon SS
Cancer Med 2018 Mar;7(3):831-841. Epub 2018 Jan 29 doi: 10.1002/cam4.1340. PMID: 29380550Free PMC Article
Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia.
Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J
Int J Clin Exp Pathol 2015;8(6):7494-8. Epub 2015 Jun 1 PMID: 26261659Free PMC Article

Prognosis

The Yin and Yang-Like Clinical Implications of the CDKN2A/ARF/CDKN2B Gene Cluster in Acute Lymphoblastic Leukemia.
González-Gil C, Ribera J, Ribera JM, Genescà E
Genes (Basel) 2021 Jan 9;12(1) doi: 10.3390/genes12010079. PMID: 33435487Free PMC Article
ETV6/RUNX1-positive childhood acute lymphoblastic leukemia (ALL): The spectrum of clonal heterogeneity and its impact on prognosis.
Ampatzidou M, Papadhimitriou SI, Paterakis G, Pavlidis D, Tsitsikas Κ, Kostopoulos IV, Papadakis V, Vassilopoulos G, Polychronopoulou S
Cancer Genet 2018 Aug;224-225:1-11. Epub 2018 Mar 27 doi: 10.1016/j.cancergen.2018.03.001. PMID: 29778230
Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomodulatory agents response: redefining high-risk multiple myeloma in Asian patients.
Byun JM, Shin DY, Hong J, Kim I, Kim HK, Lee DS, Koh Y, Yoon SS
Cancer Med 2018 Mar;7(3):831-841. Epub 2018 Jan 29 doi: 10.1002/cam4.1340. PMID: 29380550Free PMC Article
Intratumoral patterns of clonal evolution in gliomas.
Vital AL, Tabernero MD, Crespo I, Rebelo O, Tão H, Gomes F, Lopes MC, Orfao A
Neurogenetics 2010 May;11(2):227-39. Epub 2009 Sep 17 doi: 10.1007/s10048-009-0217-x. PMID: 19760258
Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics.
Primo D, Tabernero MD, Perez JJ, Rasillo A, Sayagués JM, Espinosa AB, Lopez-Berges MC, García-Sanz R, Gutierrez NC, Hernandez JM, Romero M, Osuna CS, Giralt M, Barbon M, San Miguel JF, Orfao A
Leukemia 2005 May;19(5):713-20. doi: 10.1038/sj.leu.2403714. PMID: 15789066

Clinical prediction guides

The Yin and Yang-Like Clinical Implications of the CDKN2A/ARF/CDKN2B Gene Cluster in Acute Lymphoblastic Leukemia.
González-Gil C, Ribera J, Ribera JM, Genescà E
Genes (Basel) 2021 Jan 9;12(1) doi: 10.3390/genes12010079. PMID: 33435487Free PMC Article
Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomodulatory agents response: redefining high-risk multiple myeloma in Asian patients.
Byun JM, Shin DY, Hong J, Kim I, Kim HK, Lee DS, Koh Y, Yoon SS
Cancer Med 2018 Mar;7(3):831-841. Epub 2018 Jan 29 doi: 10.1002/cam4.1340. PMID: 29380550Free PMC Article
Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia.
Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J
Int J Clin Exp Pathol 2015;8(6):7494-8. Epub 2015 Jun 1 PMID: 26261659Free PMC Article
Genetic heterogeneity of BCR/ABL+ adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics.
Primo D, Tabernero MD, Perez JJ, Rasillo A, Sayagués JM, Espinosa AB, Lopez-Berges MC, García-Sanz R, Gutierrez NC, Hernandez JM, Romero M, Osuna CS, Giralt M, Barbon M, San Miguel JF, Orfao A
Leukemia 2005 May;19(5):713-20. doi: 10.1038/sj.leu.2403714. PMID: 15789066
Genomic imbalances in T-cell acute lymphoblastic leukemia cell lines.
Gebhart E, Thoma K, Verdorfer I, Drexler HG, Efferth T
Int J Oncol 2002 Oct;21(4):887-94. PMID: 12239631

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