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Increased circulating guanosine concentration

MedGen UID:
1783036
•Concept ID:
C5539527
•
Finding
HPO: HP:0033340

Definition

Increased concentration of guanosine in the blood circulation. [from HPO]

Conditions with this feature

Purine-nucleoside phosphorylase deficiency
MedGen UID:
75653
•Concept ID:
C0268125
•
Disease or Syndrome
Purine nucleoside phosphorylase deficiency is a rare autosomal recessive immunodeficiency disorder characterized mainly by decreased T-cell function. Some patients also have neurologic impairment (review by Aust et al., 1992).
See: Condition Record
Purine-nucleoside phosphorylase deficiency

Professional guidelines

PubMed

Targetting cancer with Ru(III/II)-phosphodiesterase inhibitor adducts: a novel approach in the treatment of cancer.
Koiri RK, Mehrotra A, Trigun SK
Med Hypotheses 2013 Jun;80(6):841-6. Epub 2013 Apr 12 doi: 10.1016/j.mehy.2013.03.029. PMID: 23587478
Atrial natriuretic peptide and cyclic guanosine-3'5'-monophosphate in hypertensive pregnancy and during nifedipine treatment.
Manninen A, Vuorinen P, Laippala P, Tuimala R, Vapaatalo H
Pharmacol Toxicol 1994 Mar;74(3):153-7. doi: 10.1111/j.1600-0773.1994.tb01091.x. PMID: 8008721

Recent clinical studies

Etiology

Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP.
Reginauld SH, Cannone V, Iyer S, Scott C, Bailey K, Schaefer J, Chen Y, Sangaralingham SJ, Burnett JC Jr
JACC Heart Fail 2019 Oct;7(10):891-898. Epub 2019 Sep 11 doi: 10.1016/j.jchf.2019.05.012. PMID: 31521687Free PMC Article
Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations.
Guest J, Grant R, Garg M, Mori TA, Croft KD, Bilgin A
J Neuroinflammation 2014 Jul 1;11:117. doi: 10.1186/1742-2094-11-117. PMID: 24985027Free PMC Article
Protection of endothelial function: targets for nutritional and pharmacological interventions.
Sudano I, Spieker LE, Hermann F, Flammer A, Corti R, Noll G, Lüscher TF
J Cardiovasc Pharmacol 2006;47 Suppl 2:S136-50; discussion S172-6. doi: 10.1097/00005344-200606001-00008. PMID: 16794451
Protection of endothelial function.
Spieker LE, Lüscher TF
Handb Exp Pharmacol 2005;(170):619-44. doi: 10.1007/3-540-27661-0_23. PMID: 16596817
Molsidomine: alternative approaches to treat myocardial ischemia.
Nitz RE, Fiedler VB
Pharmacotherapy 1987 Jan-Feb;7(1):28-37. doi: 10.1002/j.1875-9114.1987.tb03503.x. PMID: 3554158

Diagnosis

Ethiopian Native Highlander's Adaptation to Chronic High-Altitude Hypoxia.
Getu A
Biomed Res Int 2022;2022:5749382. Epub 2022 Apr 15 doi: 10.1155/2022/5749382. PMID: 35463974Free PMC Article
Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.
Morrow DA, Velazquez EJ, DeVore AD, Prescott MF, Duffy CI, Gurmu Y, McCague K, Rocha R, Braunwald E
Eur Heart J 2019 Oct 21;40(40):3345-3352. doi: 10.1093/eurheartj/ehz240. PMID: 31093657Free PMC Article
Neurovascular mechanisms of hypertension in pregnancy.
Stennett AK, Khalil RA
Curr Neurovasc Res 2006 May;3(2):131-48. doi: 10.2174/156720206776875885. PMID: 16719796
An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans.
Lafontan M, Moro C, Sengenes C, Galitzky J, Crampes F, Berlan M
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2032-42. Epub 2005 Aug 25 doi: 10.1161/01.ATV.0000183728.14712.d8. PMID: 16123323
Effect of chronic hypoxia on K+ channels: regulation in human pulmonary vascular smooth muscle cells.
Peng W, Hoidal JR, Karwande SV, Farrukh IS
Am J Physiol 1997 Apr;272(4 Pt 1):C1271-8. doi: 10.1152/ajpcell.1997.272.4.C1271. PMID: 9142852

Therapy

Combined Inhibition of Phosphodiesterase-5 and -9 in Experimental Heart Failure.
Rademaker MT, Scott NJA, Charles CJ, Richards AM
JACC Heart Fail 2024 Jan;12(1):100-113. Epub 2023 Nov 1 doi: 10.1016/j.jchf.2023.08.028. PMID: 37921801
Changes in mid-regional pro-adrenomedullin during treatment with sacubitril/valsartan.
Myhre PL, Liu Y, Kulac IJ, Claggett BL, Prescott MF, Felker GM, Butler J, Piña IL, Rouleau JL, Zile MR, McMurray JJV, Ward JH, Solomon SD, Januzzi JL
Eur J Heart Fail 2023 Aug;25(8):1396-1405. Epub 2023 Jul 11 doi: 10.1002/ejhf.2957. PMID: 37401523
Augmentation of Natriuretic Peptide Bioactivity via Combined Inhibition of Neprilysin and Phosphodiesterase-9 in Heart Failure.
Scott NJA, Prickett TCR, Charles CJ, Frampton CM, Richards AM, Rademaker MT
JACC Heart Fail 2023 Feb;11(2):227-239. Epub 2023 Jan 11 doi: 10.1016/j.jchf.2022.11.006. PMID: 36752488
Protection of endothelial function.
Spieker LE, Lüscher TF
Handb Exp Pharmacol 2005;(170):619-44. doi: 10.1007/3-540-27661-0_23. PMID: 16596817
Molsidomine: alternative approaches to treat myocardial ischemia.
Nitz RE, Fiedler VB
Pharmacotherapy 1987 Jan-Feb;7(1):28-37. doi: 10.1002/j.1875-9114.1987.tb03503.x. PMID: 3554158

Prognosis

Evidence for functional heterogeneity of circulating B-type natriuretic peptide.
Liang F, O'Rear J, Schellenberger U, Tai L, Lasecki M, Schreiner GF, Apple FS, Maisel AS, Pollitt NS, Protter AA
J Am Coll Cardiol 2007 Mar 13;49(10):1071-8. Epub 2007 Feb 26 doi: 10.1016/j.jacc.2006.10.063. PMID: 17349887
Protection of endothelial function: targets for nutritional and pharmacological interventions.
Sudano I, Spieker LE, Hermann F, Flammer A, Corti R, Noll G, Lüscher TF
J Cardiovasc Pharmacol 2006;47 Suppl 2:S136-50; discussion S172-6. doi: 10.1097/00005344-200606001-00008. PMID: 16794451
Protection of endothelial function.
Spieker LE, Lüscher TF
Handb Exp Pharmacol 2005;(170):619-44. doi: 10.1007/3-540-27661-0_23. PMID: 16596817
Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease.
D'Odorico A, Bortolan S, Cardin R, D'Inca' R, Martines D, Ferronato A, Sturniolo GC
Scand J Gastroenterol 2001 Dec;36(12):1289-94. doi: 10.1080/003655201317097146. PMID: 11761019
Are phospholipase A2 and nitric oxide involved in the alterations in peritoneal transport during CAPD peritonitis?
Douma CE, de Waart DR, Struijk DG, Krediet RT
J Lab Clin Med 1998 Oct;132(4):329-40. doi: 10.1016/s0022-2143(98)90047-6. PMID: 9794705

Clinical prediction guides

Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m).
Luks AM, Levett D, Martin DS, Goss CH, Mitchell K, Fernandez BO, Feelisch M, Grocott MP, Swenson ER; Caudwell Xtreme Everest Investigators
Exp Physiol 2017 Jun 1;102(6):711-724. Epub 2017 May 21 doi: 10.1113/EP086083. PMID: 28390080
Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations.
Guest J, Grant R, Garg M, Mori TA, Croft KD, Bilgin A
J Neuroinflammation 2014 Jul 1;11:117. doi: 10.1186/1742-2094-11-117. PMID: 24985027Free PMC Article
Genotoxic effects of neutrophils and hypochlorous acid.
Güngör N, Knaapen AM, Munnia A, Peluso M, Haenen GR, Chiu RK, Godschalk RW, van Schooten FJ
Mutagenesis 2010 Mar;25(2):149-54. Epub 2009 Nov 5 doi: 10.1093/mutage/gep053. PMID: 19892774
Protection of endothelial function: targets for nutritional and pharmacological interventions.
Sudano I, Spieker LE, Hermann F, Flammer A, Corti R, Noll G, Lüscher TF
J Cardiovasc Pharmacol 2006;47 Suppl 2:S136-50; discussion S172-6. doi: 10.1097/00005344-200606001-00008. PMID: 16794451
An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans.
Lafontan M, Moro C, Sengenes C, Galitzky J, Crampes F, Berlan M
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2032-42. Epub 2005 Aug 25 doi: 10.1161/01.ATV.0000183728.14712.d8. PMID: 16123323

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