Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Increased circulating guanosine concentration

MedGen UID:: 1783036
•Concept ID:: C5539527
•: Finding

HPO:	HP:0033340

Definition

Increased concentration of guanosine in the blood circulation. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased circulating guanosine concentration

Abnormality of metabolism/homeostasis
- Abnormal circulating metabolite concentration
  - Abnormal circulating nitrogen compound concentration
    - Abnormal circulating nucleobase concentration
      - Abnormal circulating purine concentration
        Increased circulating purine concentration
        Increased circulating guanosine concentration

Conditions with this feature

Purine-nucleoside phosphorylase deficiency

MedGen UID:: 75653
•Concept ID:: C0268125
•: Disease or Syndrome

Purine nucleoside phosphorylase deficiency is a rare autosomal recessive immunodeficiency disorder characterized mainly by decreased T-cell function. Some patients also have neurologic impairment (review by Aust et al., 1992).

See: Condition Record

Purine-nucleoside phosphorylase deficiency

Professional guidelines

PubMed

Targetting cancer with Ru(III/II)-phosphodiesterase inhibitor adducts: a novel approach in the treatment of cancer.

Koiri RK, Mehrotra A, Trigun SK
Med Hypotheses 2013 Jun;80(6):841-6. Epub 2013 Apr 12 doi: 10.1016/j.mehy.2013.03.029. PMID: 23587478

Atrial natriuretic peptide and cyclic guanosine-3'5'-monophosphate in hypertensive pregnancy and during nifedipine treatment.

Manninen A, Vuorinen P, Laippala P, Tuimala R, Vapaatalo H
Pharmacol Toxicol 1994 Mar;74(3):153-7. doi: 10.1111/j.1600-0773.1994.tb01091.x. PMID: 8008721

See all (2)

Recent clinical studies

Etiology

Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP.

Reginauld SH, Cannone V, Iyer S, Scott C, Bailey K, Schaefer J, Chen Y, Sangaralingham SJ, Burnett JC Jr
JACC Heart Fail 2019 Oct;7(10):891-898. Epub 2019 Sep 11 doi: 10.1016/j.jchf.2019.05.012. PMID: 31521687 Free PMC Article

Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.

Morrow DA, Velazquez EJ, DeVore AD, Prescott MF, Duffy CI, Gurmu Y, McCague K, Rocha R, Braunwald E
Eur Heart J 2019 Oct 21;40(40):3345-3352. doi: 10.1093/eurheartj/ehz240. PMID: 31093657 Free PMC Article

Protection of endothelial function: targets for nutritional and pharmacological interventions.

Sudano I, Spieker LE, Hermann F, Flammer A, Corti R, Noll G, Lüscher TF
J Cardiovasc Pharmacol 2006;47 Suppl 2:S136-50; discussion S172-6. doi: 10.1097/00005344-200606001-00008. PMID: 16794451

Protection of endothelial function.

Spieker LE, Lüscher TF
Handb Exp Pharmacol 2005;(170):619-44. doi: 10.1007/3-540-27661-0_23. PMID: 16596817

Molsidomine: alternative approaches to treat myocardial ischemia.

Nitz RE, Fiedler VB
Pharmacotherapy 1987 Jan-Feb;7(1):28-37. doi: 10.1002/j.1875-9114.1987.tb03503.x. PMID: 3554158

See all (33)

Diagnosis

Ethiopian Native Highlander's Adaptation to Chronic High-Altitude Hypoxia.

Getu A
Biomed Res Int 2022;2022:5749382. Epub 2022 Apr 15 doi: 10.1155/2022/5749382. PMID: 35463974 Free PMC Article

Cardiovascular biomarkers in patients with acute decompensated heart failure randomized to sacubitril-valsartan or enalapril in the PIONEER-HF trial.

Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury.

Halstrom A, MacDonald E, Neil C, Arendts G, Fatovich D, Fitzgerald M
J Clin Neurosci 2017 Jan;35:104-108. Epub 2016 Sep 30 doi: 10.1016/j.jocn.2016.09.006. PMID: 27697434

Neurovascular mechanisms of hypertension in pregnancy.

Stennett AK, Khalil RA
Curr Neurovasc Res 2006 May;3(2):131-48. doi: 10.2174/156720206776875885. PMID: 16719796

An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans.

Lafontan M, Moro C, Sengenes C, Galitzky J, Crampes F, Berlan M
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2032-42. Epub 2005 Aug 25 doi: 10.1161/01.ATV.0000183728.14712.d8. PMID: 16123323

See all (12)

Therapy

Changes in mid-regional pro-adrenomedullin during treatment with sacubitril/valsartan.

Myhre PL, Liu Y, Kulac IJ, Claggett BL, Prescott MF, Felker GM, Butler J, Piña IL, Rouleau JL, Zile MR, McMurray JJV, Ward JH, Solomon SD, Januzzi JL
Eur J Heart Fail 2023 Aug;25(8):1396-1405. Epub 2023 Jul 11 doi: 10.1002/ejhf.2957. PMID: 37401523

Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy.

Díez J
Eur J Heart Fail 2017 Feb;19(2):167-176. Epub 2016 Oct 21 doi: 10.1002/ejhf.656. PMID: 27766748 Free PMC Article

Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: results from a crossover study.

Noguchi T, Kobayashi J, Yagi K, Nohara A, Yamaaki N, Sugihara M, Ito N, Oka R, Kawashiri MA, Tada H, Takata M, Inazu A, Yamagishi M, Mabuchi H
Atherosclerosis 2011 Jul;217(1):165-70. Epub 2011 Feb 22 doi: 10.1016/j.atherosclerosis.2011.02.012. PMID: 21411093

Protection of endothelial function.

Spieker LE, Lüscher TF
Handb Exp Pharmacol 2005;(170):619-44. doi: 10.1007/3-540-27661-0_23. PMID: 16596817

Molsidomine: alternative approaches to treat myocardial ischemia.

Nitz RE, Fiedler VB
Pharmacotherapy 1987 Jan-Feb;7(1):28-37. doi: 10.1002/j.1875-9114.1987.tb03503.x. PMID: 3554158

See all (45)

Prognosis

Evidence for functional heterogeneity of circulating B-type natriuretic peptide.

Liang F, O'Rear J, Schellenberger U, Tai L, Lasecki M, Schreiner GF, Apple FS, Maisel AS, Pollitt NS, Protter AA
J Am Coll Cardiol 2007 Mar 13;49(10):1071-8. Epub 2007 Feb 26 doi: 10.1016/j.jacc.2006.10.063. PMID: 17349887

Protection of endothelial function: targets for nutritional and pharmacological interventions.

Sudano I, Spieker LE, Hermann F, Flammer A, Corti R, Noll G, Lüscher TF
J Cardiovasc Pharmacol 2006;47 Suppl 2:S136-50; discussion S172-6. doi: 10.1097/00005344-200606001-00008. PMID: 16794451

Protection of endothelial function.

Spieker LE, Lüscher TF
Handb Exp Pharmacol 2005;(170):619-44. doi: 10.1007/3-540-27661-0_23. PMID: 16596817

Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease.

D'Odorico A, Bortolan S, Cardin R, D'Inca' R, Martines D, Ferronato A, Sturniolo GC
Scand J Gastroenterol 2001 Dec;36(12):1289-94. doi: 10.1080/003655201317097146. PMID: 11761019

Are phospholipase A2 and nitric oxide involved in the alterations in peritoneal transport during CAPD peritonitis?

Douma CE, de Waart DR, Struijk DG, Krediet RT
J Lab Clin Med 1998 Oct;132(4):329-40. doi: 10.1016/s0022-2143(98)90047-6. PMID: 9794705

See all (11)

Clinical prediction guides

Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m).

Luks AM, Levett D, Martin DS, Goss CH, Mitchell K, Fernandez BO, Feelisch M, Grocott MP, Swenson ER; Caudwell Xtreme Everest Investigators
Exp Physiol 2017 Jun 1;102(6):711-724. Epub 2017 May 21 doi: 10.1113/EP086083. PMID: 28390080

Elevation of oxidative stress indicators in a pilot study of plasma following traumatic brain injury.

Halstrom A, MacDonald E, Neil C, Arendts G, Fatovich D, Fitzgerald M
J Clin Neurosci 2017 Jan;35:104-108. Epub 2016 Sep 30 doi: 10.1016/j.jocn.2016.09.006. PMID: 27697434

Protection of endothelial function: targets for nutritional and pharmacological interventions.

Sudano I, Spieker LE, Hermann F, Flammer A, Corti R, Noll G, Lüscher TF
J Cardiovasc Pharmacol 2006;47 Suppl 2:S136-50; discussion S172-6. doi: 10.1097/00005344-200606001-00008. PMID: 16794451

An unsuspected metabolic role for atrial natriuretic peptides: the control of lipolysis, lipid mobilization, and systemic nonesterified fatty acids levels in humans.

Lafontan M, Moro C, Sengenes C, Galitzky J, Crampes F, Berlan M
Arterioscler Thromb Vasc Biol 2005 Oct;25(10):2032-42. Epub 2005 Aug 25 doi: 10.1161/01.ATV.0000183728.14712.d8. PMID: 16123323

Acute volume expansion in normal pregnancy and preeclampsia. Effects on plasma atrial natriuretic peptide (ANP) and cyclic guanosine monophosphate (cGMP) concentrations and feto-maternal circulation.

Grunewald C, Nisell H, Carlström K, Kublickas M, Randmaa I, Nylund L
Acta Obstet Gynecol Scand 1994 Apr;73(4):294-9. doi: 10.3109/00016349409015766. PMID: 8160534

See all (30)

MedGen

National Center for Biotechnology Information

Send to:

Increased circulating guanosine concentration

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity