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Visceral epithelial cell hyperplasia

MedGen UID:
1783094
•Concept ID:
C5539508
•
Finding
Synonym: Podocyte hyperplasia
 
HPO: HP:0033314

Definition

Increased number of visceral epithelial cells (2 or more layers), often with crowding and multilayering, but without continuity with the parietal epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVisceral epithelial cell hyperplasia

Recent clinical studies

Etiology

Collapsing Glomerulopathy.
Koirala A, Akilesh S, Jefferson JA
Adv Kidney Dis Health 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008. PMID: 39084754Free PMC Article
Proteinuria in thrombotic microangiopathy is associated with partial podocytopathy.
Moore M, Afolayan-Oloye O, Kroneman O, Li W, Kanaan HD, Zhang PL
Ultrastruct Pathol 2023 May 4;47(3):219-226. Epub 2023 Mar 12 doi: 10.1080/01913123.2023.2189341. PMID: 36906888
Pathobiology of focal segmental glomerulosclerosis: new developments.
D'Agati VD
Curr Opin Nephrol Hypertens 2012 May;21(3):243-50. doi: 10.1097/MNH.0b013e32835200df. PMID: 22357339
HIV-associated nephropathy: experimental models.
Avila-Casado C, Fortoul TI, Chugh SS
Contrib Nephrol 2011;169:270-285. Epub 2011 Jan 20 doi: 10.1159/000320212. PMID: 21252526
Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies.
El Karoui K, Hill GS, Karras A, Moulonguet L, Caudwell V, Loupy A, Bruneval P, Jacquot C, Nochy D
Kidney Int 2011 Mar;79(6):643-654. Epub 2010 Dec 22 doi: 10.1038/ki.2010.460. PMID: 21178978

Diagnosis

Collagen IV and Podocyte-Related Gene Variants in Patients with Concurrent IgA Nephropathy and Thin Basement Membrane Nephropathy.
Xu H, Yu X, Li Y, Huang Z, Zhang L, Min Q, Bi J, Li Z, Liu L, Liang Y, Xu Z, Sun H, Yang S, Shao M
Nephron 2023;147(5):301-310. Epub 2022 Nov 8 doi: 10.1159/000526971. PMID: 36349777Free PMC Article
The association between adult-onset Still's disease and collapsing glomerulopathy: a case report.
Orentas M, Patel N, Rodby R, Hassan S
J Med Case Rep 2022 Oct 14;16(1):370. doi: 10.1186/s13256-022-03606-1. PMID: 36229843Free PMC Article
Role of progenitor cell marker CD133 in supporting diagnosis of collapsing glomerulopathy.
Xiao AY, Kanaan HD, Lai Z, Li W, Zhang PL
Int Urol Nephrol 2022 Aug;54(8):1957-1968. Epub 2022 Jan 3 doi: 10.1007/s11255-021-03078-0. PMID: 34978023Free PMC Article
WT1 immunoenzyme staining using SurePath(™) processed urine cytology helps to detect kidney disease.
Ohsaki H, Sofue T, Kawakami K, Nishijima Y, Hara T, Matsunaga T, Kushida Y, Haba R, Shigematsu Y, Irino S, Norimatsu Y
Cytopathology 2016 Feb;27(1):43-9. Epub 2015 Feb 14 doi: 10.1111/cyt.12227. PMID: 25683486
Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion.
Ikezumi Y, Suzuki T, Karasawa T, Kaneko U, Yamada T, Hasegawa H, Nagata M, Saitoh A
Hum Pathol 2014 Aug;45(8):1778-83. Epub 2014 Apr 18 doi: 10.1016/j.humpath.2014.03.017. PMID: 24856573

Therapy

The association between adult-onset Still's disease and collapsing glomerulopathy: a case report.
Orentas M, Patel N, Rodby R, Hassan S
J Med Case Rep 2022 Oct 14;16(1):370. doi: 10.1186/s13256-022-03606-1. PMID: 36229843Free PMC Article
Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice.
Melica ME, Antonelli G, Semeraro R, Angelotti ML, Lugli G, Landini S, Ravaglia F, Regina G, Conte C, De Chiara L, Peired AJ, Mazzinghi B, Donati M, Molli A, Steiger S, Magi A, Bartalucci N, Raglianti V, Guzzi F, Maggi L, Annunziato F, Burger A, Lazzeri E, Anders HJ, Lasagni L, Romagnani P
Sci Transl Med 2022 Aug 10;14(657):eabg3277. doi: 10.1126/scitranslmed.abg3277. PMID: 35947676Free PMC Article
A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals.
Palamides P, Jodeleit H, Föhlinger M, Beigel F, Herbach N, Mueller T, Wolf E, Siebeck M, Gropp R
Dis Model Mech 2016 Sep 1;9(9):985-97. Epub 2016 Aug 4 doi: 10.1242/dmm.025452. PMID: 27491073Free PMC Article
Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells.
Dijkman HB, Weening JJ, Smeets B, Verrijp KC, van Kuppevelt TH, Assmann KK, Steenbergen EJ, Wetzels JF
Kidney Int 2006 Jul;70(2):338-44. Epub 2006 Jun 7 doi: 10.1038/sj.ki.5001574. PMID: 16761013
Idiopathic collapsing glomerulopathy in children.
Singh HK, Baldree LA, McKenney DW, Hogan SL, Jennette JC
Pediatr Nephrol 2000 Feb;14(2):132-7. doi: 10.1007/s004670050028. PMID: 10684363

Prognosis

Collapsing Glomerulopathy.
Koirala A, Akilesh S, Jefferson JA
Adv Kidney Dis Health 2024 Jul;31(4):290-298. doi: 10.1053/j.akdh.2024.03.008. PMID: 39084754Free PMC Article
Collagen IV and Podocyte-Related Gene Variants in Patients with Concurrent IgA Nephropathy and Thin Basement Membrane Nephropathy.
Xu H, Yu X, Li Y, Huang Z, Zhang L, Min Q, Bi J, Li Z, Liu L, Liang Y, Xu Z, Sun H, Yang S, Shao M
Nephron 2023;147(5):301-310. Epub 2022 Nov 8 doi: 10.1159/000526971. PMID: 36349777Free PMC Article
Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies.
El Karoui K, Hill GS, Karras A, Moulonguet L, Caudwell V, Loupy A, Bruneval P, Jacquot C, Nochy D
Kidney Int 2011 Mar;79(6):643-654. Epub 2010 Dec 22 doi: 10.1038/ki.2010.460. PMID: 21178978
Collapsing glomerulopathy.
Schwimmer JA, Markowitz GS, Valeri A, Appel GB
Semin Nephrol 2003 Mar;23(2):209-18. doi: 10.1053/snep.2003.50019. PMID: 12704581
Collapsing glomerulopathy: clinical characteristics and follow-up.
Grcevska L, Polenakovik M
Am J Kidney Dis 1999 Apr;33(4):652-7. doi: 10.1016/s0272-6386(99)70215-5. PMID: 10196005

Clinical prediction guides

Collagen IV and Podocyte-Related Gene Variants in Patients with Concurrent IgA Nephropathy and Thin Basement Membrane Nephropathy.
Xu H, Yu X, Li Y, Huang Z, Zhang L, Min Q, Bi J, Li Z, Liu L, Liang Y, Xu Z, Sun H, Yang S, Shao M
Nephron 2023;147(5):301-310. Epub 2022 Nov 8 doi: 10.1159/000526971. PMID: 36349777Free PMC Article
Focal Segmental Glomerulosclerosis Superimposed on Transplant Glomerulopathy: Implications for Graft Survival.
Zhu Y, Fan Y, Xu F, Liang S, Liang D, Li P, Xia Y, Zhu X, Yang F, Chen J, Zeng C
Am J Nephrol 2021;52(10-11):788-797. Epub 2021 Nov 8 doi: 10.1159/000519648. PMID: 34749369
A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastrointestinal tract and decreased white adipose tissue.
Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Mulvaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen XL, Randell SH, Weissman BE, Major MB
J Pathol 2020 Oct;252(2):125-137. Epub 2020 Aug 29 doi: 10.1002/path.5504. PMID: 32619021Free PMC Article
Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation.
Estrada CC, Paladugu P, Guo Y, Pace J, Revelo MP, Salant DJ, Shankland SJ, D'Agati VD, Mehrotra A, Cardona S, Bialkowska AB, Yang VW, He JC, Mallipattu SK
JCI Insight 2018 Jun 21;3(12) doi: 10.1172/jci.insight.98214. PMID: 29925693Free PMC Article
Enterochromaffin cell hyperplasia in irritable pouch syndrome.
Shen B, Liu W, Remzi FH, Shao Z, Lu H, DeLaMotte C, Hammel J, Queener E, Bambrick ML, Fazio VW
Am J Gastroenterol 2008 Sep;103(9):2293-300. Epub 2008 Aug 12 doi: 10.1111/j.1572-0241.2008.01990.x. PMID: 18702649

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