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Myocardial late gadolinium enhancement

MedGen UID:
1783233
•Concept ID:
C5539856
•
Finding
Synonym: Delayed myocardial gadolinium enhancement
 
HPO: HP:4000004

Definition

Areas of high signal intensity in magnetic resonance imaging of the heart appearing 10 to 15 minutes after injection of the intercellular contrast agent gadolinium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial late gadolinium enhancement

Conditions with this feature

Cardiomyopathy, familial hypertrophic, 28
MedGen UID:
1779612
•Concept ID:
C5543616
•
Disease or Syndrome
Familial hypertrophic cardiomyopathy-28 (CMH28) is characterized by asymmetric septal hypertrophy, atrial fibrillation and nonsustained ventricular tachycardia, and risk of sudden death. Dyspnea is the most common symptom, but more than half of affected individuals are asymptomatic. Hypertrabeculation of the left ventricle with noncompaction has been observed in some patients (Ochoa et al., 2018). For a general phenotypic description and discussion of genetic heterogeneity of familial hypertrophic cardiomyopathy, see CMH1 (192600).
See: Condition Record
Cardiomyopathy, familial hypertrophic, 28

Professional guidelines

PubMed

Evolving Diagnostic Criteria for Arrhythmogenic Cardiomyopathy.
Corrado D, Zorzi A, Cipriani A, Bauce B, Bariani R, Beffagna G, De Lazzari M, Migliore F, Pilichou K, Rampazzo A, Rigato I, Rizzo S, Thiene G, Perazzolo Marra M, Basso C
J Am Heart Assoc 2021 Sep 21;10(18):e021987. Epub 2021 Sep 17 doi: 10.1161/JAHA.121.021987. PMID: 34533054Free PMC Article
Cardiac manifestations of sarcoidosis: diagnosis and management.
Birnie DH, Kandolin R, Nery PB, Kupari M
Eur Heart J 2017 Sep 14;38(35):2663-2670. doi: 10.1093/eurheartj/ehw328. PMID: 27469375

Recent clinical studies

Etiology

Cardiac MRI e-prime predicts myocardial late gadolinium enhancement and diastolic dysfunction in hypertrophic cardiomyopathy.
O'Brien AC, MacDermott R, Keane S, Ryan DT, McVeigh N, Durand R, Ferre M, Murphy DJ, Teekakirikul P, Keane D, McDonald K, Ledwidge M, Dodd JD
Eur J Radiol 2022 Apr;149:110192. Epub 2022 Feb 3 doi: 10.1016/j.ejrad.2022.110192. PMID: 35158215
Distinct non-ischemic myocardial late gadolinium enhancement lesions in patients with type 2 diabetes.
Bojer AS, Sørensen MH, Vejlstrup N, Goetze JP, Gæde P, Madsen PL
Cardiovasc Diabetol 2020 Oct 22;19(1):184. doi: 10.1186/s12933-020-01160-y. PMID: 33092588Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Myocardial Late Gadolinium Enhancement: Accuracy of T1 Mapping-based Synthetic Inversion-Recovery Imaging.
Varga-Szemes A, van der Geest RJ, Spottiswoode BS, Suranyi P, Ruzsics B, De Cecco CN, Muscogiuri G, Cannaò PM, Fox MA, Wichmann JL, Vliegenthart R, Schoepf UJ
Radiology 2016 Feb;278(2):374-82. Epub 2015 Jul 30 doi: 10.1148/radiol.2015150162. PMID: 26230908
The prognostic impact of myocardial late gadolinium enhancement.
Panovsky R, Pleva M, Feitova V, Kruzliak P, Meluzin J, Kincl V
Cardiol Rev 2014 May-Jun;22(3):128-39. doi: 10.1097/CRD.0000000000000002. PMID: 24699110

Diagnosis

Cardiac MRI e-prime predicts myocardial late gadolinium enhancement and diastolic dysfunction in hypertrophic cardiomyopathy.
O'Brien AC, MacDermott R, Keane S, Ryan DT, McVeigh N, Durand R, Ferre M, Murphy DJ, Teekakirikul P, Keane D, McDonald K, Ledwidge M, Dodd JD
Eur J Radiol 2022 Apr;149:110192. Epub 2022 Feb 3 doi: 10.1016/j.ejrad.2022.110192. PMID: 35158215
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Myocardial Late Gadolinium Enhancement: Accuracy of T1 Mapping-based Synthetic Inversion-Recovery Imaging.
Varga-Szemes A, van der Geest RJ, Spottiswoode BS, Suranyi P, Ruzsics B, De Cecco CN, Muscogiuri G, Cannaò PM, Fox MA, Wichmann JL, Vliegenthart R, Schoepf UJ
Radiology 2016 Feb;278(2):374-82. Epub 2015 Jul 30 doi: 10.1148/radiol.2015150162. PMID: 26230908
The prognostic impact of myocardial late gadolinium enhancement.
Panovsky R, Pleva M, Feitova V, Kruzliak P, Meluzin J, Kincl V
Cardiol Rev 2014 May-Jun;22(3):128-39. doi: 10.1097/CRD.0000000000000002. PMID: 24699110
Emerging concepts for myocardial late gadolinium enhancement MRI.
Doltra A, Amundsen BH, Gebker R, Fleck E, Kelle S
Curr Cardiol Rev 2013 Aug;9(3):185-90. doi: 10.2174/1573403x113099990030. PMID: 23909638Free PMC Article

Therapy

The utility of cardiac magnetic resonance imaging in the diagnosis of adult patients with acute myocarditis: a systematic review and meta-analysis.
Khanna S, Amarasekera AT, Li C, Bhat A, Chen HHL, Gan GCH, Ugander M, Tan TC
Int J Cardiol 2022 Sep 15;363:225-239. Epub 2022 Jun 18 doi: 10.1016/j.ijcard.2022.06.047. PMID: 35724801
Cardiac MRI Findings in COVID-19 Vaccine-Related Myocarditis: A Pooled Analysis of 468 Patients.
Samimisedeh P, Jafari Afshar E, Shafiabadi Hassani N, Rastad H
J Magn Reson Imaging 2022 Oct;56(4):971-982. Epub 2022 May 25 doi: 10.1002/jmri.28268. PMID: 35612967Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Myocardial Late Gadolinium Enhancement: Accuracy of T1 Mapping-based Synthetic Inversion-Recovery Imaging.
Varga-Szemes A, van der Geest RJ, Spottiswoode BS, Suranyi P, Ruzsics B, De Cecco CN, Muscogiuri G, Cannaò PM, Fox MA, Wichmann JL, Vliegenthart R, Schoepf UJ
Radiology 2016 Feb;278(2):374-82. Epub 2015 Jul 30 doi: 10.1148/radiol.2015150162. PMID: 26230908
Incidence and prognostic significance of myocardial late gadolinium enhancement in patients with sarcoidosis without cardiac manifestation.
Nagai T, Kohsaka S, Okuda S, Anzai T, Asano K, Fukuda K
Chest 2014 Oct;146(4):1064-1072. doi: 10.1378/chest.14-0139. PMID: 24853830

Prognosis

Cardiac MRI e-prime predicts myocardial late gadolinium enhancement and diastolic dysfunction in hypertrophic cardiomyopathy.
O'Brien AC, MacDermott R, Keane S, Ryan DT, McVeigh N, Durand R, Ferre M, Murphy DJ, Teekakirikul P, Keane D, McDonald K, Ledwidge M, Dodd JD
Eur J Radiol 2022 Apr;149:110192. Epub 2022 Feb 3 doi: 10.1016/j.ejrad.2022.110192. PMID: 35158215
Distinct non-ischemic myocardial late gadolinium enhancement lesions in patients with type 2 diabetes.
Bojer AS, Sørensen MH, Vejlstrup N, Goetze JP, Gæde P, Madsen PL
Cardiovasc Diabetol 2020 Oct 22;19(1):184. doi: 10.1186/s12933-020-01160-y. PMID: 33092588Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
The prognostic impact of myocardial late gadolinium enhancement.
Panovsky R, Pleva M, Feitova V, Kruzliak P, Meluzin J, Kincl V
Cardiol Rev 2014 May-Jun;22(3):128-39. doi: 10.1097/CRD.0000000000000002. PMID: 24699110
Emerging concepts for myocardial late gadolinium enhancement MRI.
Doltra A, Amundsen BH, Gebker R, Fleck E, Kelle S
Curr Cardiol Rev 2013 Aug;9(3):185-90. doi: 10.2174/1573403x113099990030. PMID: 23909638Free PMC Article

Clinical prediction guides

Cardiac MRI e-prime predicts myocardial late gadolinium enhancement and diastolic dysfunction in hypertrophic cardiomyopathy.
O'Brien AC, MacDermott R, Keane S, Ryan DT, McVeigh N, Durand R, Ferre M, Murphy DJ, Teekakirikul P, Keane D, McDonald K, Ledwidge M, Dodd JD
Eur J Radiol 2022 Apr;149:110192. Epub 2022 Feb 3 doi: 10.1016/j.ejrad.2022.110192. PMID: 35158215
Late gadolinium enhancement in patients with Tetralogy of Fallot: A systematic review.
Secchi F, Lastella G, Monti CB, Barbaro U, Capra D, Zanardo M, Sardanelli F
Eur J Radiol 2021 Mar;136:109521. Epub 2021 Jan 6 doi: 10.1016/j.ejrad.2021.109521. PMID: 33450661
Distinct non-ischemic myocardial late gadolinium enhancement lesions in patients with type 2 diabetes.
Bojer AS, Sørensen MH, Vejlstrup N, Goetze JP, Gæde P, Madsen PL
Cardiovasc Diabetol 2020 Oct 22;19(1):184. doi: 10.1186/s12933-020-01160-y. PMID: 33092588Free PMC Article
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E
JAMA Cardiol 2020 Nov 1;5(11):1265-1273. doi: 10.1001/jamacardio.2020.3557. PMID: 32730619Free PMC Article
Myocardial late gadolinium enhancement cardiovascular magnetic resonance in patients with cirrhosis.
Lossnitzer D, Steen H, Zahn A, Lehrke S, Weiss C, Weiss KH, Giannitsis E, Stremmel W, Sauer P, Katus HA, Gotthardt DN
J Cardiovasc Magn Reson 2010 Aug 13;12(1):47. doi: 10.1186/1532-429X-12-47. PMID: 20704762Free PMC Article

Recent systematic reviews

The utility of cardiac magnetic resonance imaging in the diagnosis of adult patients with acute myocarditis: a systematic review and meta-analysis.
Khanna S, Amarasekera AT, Li C, Bhat A, Chen HHL, Gan GCH, Ugander M, Tan TC
Int J Cardiol 2022 Sep 15;363:225-239. Epub 2022 Jun 18 doi: 10.1016/j.ijcard.2022.06.047. PMID: 35724801
Cardiac MRI Findings in COVID-19 Vaccine-Related Myocarditis: A Pooled Analysis of 468 Patients.
Samimisedeh P, Jafari Afshar E, Shafiabadi Hassani N, Rastad H
J Magn Reson Imaging 2022 Oct;56(4):971-982. Epub 2022 May 25 doi: 10.1002/jmri.28268. PMID: 35612967Free PMC Article
Late gadolinium enhancement in patients with Tetralogy of Fallot: A systematic review.
Secchi F, Lastella G, Monti CB, Barbaro U, Capra D, Zanardo M, Sardanelli F
Eur J Radiol 2021 Mar;136:109521. Epub 2021 Jan 6 doi: 10.1016/j.ejrad.2021.109521. PMID: 33450661

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