U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Idiopathic Dysplasia of Uncertain Significance

MedGen UID:
1783637
•Concept ID:
C5444889
•
Disease or Syndrome
Synonym: Idiopathic Dysplasia of Undetermined/Uncertain Significance

Definition

Prominent hematopoietic cell dysplasia with mild or absent cytopenia. It may progress to an overt myelodysplastic syndrome or other myeloid neoplasms such as acute myeloid leukemia, myeloproliferative neoplasm, or mast cell disorder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIdiopathic Dysplasia of Uncertain Significance

Professional guidelines

PubMed

Challenges in Diagnosing Myelodysplastic Syndromes in the Era of Genetic Testing: Proceedings of the 13th Workshop of the European Bone Marrow Working Group.
Hebeda KM, Tzankov A, Boudova L, Saft L, Hasserjian RP, de Boer M, Fend F, Orazi A, Leguit R
Pathobiology 2019;86(1):62-75. Epub 2018 Jul 6 doi: 10.1159/000489678. PMID: 29982244Free PMC Article

Recent clinical studies

Etiology

Challenges in Diagnosing Myelodysplastic Syndromes in the Era of Genetic Testing: Proceedings of the 13th Workshop of the European Bone Marrow Working Group.
Hebeda KM, Tzankov A, Boudova L, Saft L, Hasserjian RP, de Boer M, Fend F, Orazi A, Leguit R
Pathobiology 2019;86(1):62-75. Epub 2018 Jul 6 doi: 10.1159/000489678. PMID: 29982244Free PMC Article
Idiopathic cytopenia of undetermined significance (ICUS) and idiopathic dysplasia of uncertain significance (IDUS), and their distinction from low risk MDS.
Valent P, Bain BJ, Bennett JM, Wimazal F, Sperr WR, Mufti G, Horny HP
Leuk Res 2012 Jan;36(1):1-5. Epub 2011 Sep 13 doi: 10.1016/j.leukres.2011.08.016. PMID: 21920601

Diagnosis

Challenges in Diagnosing Myelodysplastic Syndromes in the Era of Genetic Testing: Proceedings of the 13th Workshop of the European Bone Marrow Working Group.
Hebeda KM, Tzankov A, Boudova L, Saft L, Hasserjian RP, de Boer M, Fend F, Orazi A, Leguit R
Pathobiology 2019;86(1):62-75. Epub 2018 Jul 6 doi: 10.1159/000489678. PMID: 29982244Free PMC Article
The relationship between idiopathic cytopenias/dysplasias of uncertain significance (ICUS/IDUS) and autoimmunity.
Barcellini W
Expert Rev Hematol 2017 Jul;10(7):649-657. Epub 2017 Jun 15 doi: 10.1080/17474086.2017.1339597. PMID: 28586251
Idiopathic cytopenia of undetermined significance (ICUS) and idiopathic dysplasia of uncertain significance (IDUS), and their distinction from low risk MDS.
Valent P, Bain BJ, Bennett JM, Wimazal F, Sperr WR, Mufti G, Horny HP
Leuk Res 2012 Jan;36(1):1-5. Epub 2011 Sep 13 doi: 10.1016/j.leukres.2011.08.016. PMID: 21920601

Prognosis

The relationship between idiopathic cytopenias/dysplasias of uncertain significance (ICUS/IDUS) and autoimmunity.
Barcellini W
Expert Rev Hematol 2017 Jul;10(7):649-657. Epub 2017 Jun 15 doi: 10.1080/17474086.2017.1339597. PMID: 28586251
Idiopathic cytopenia of undetermined significance (ICUS) and idiopathic dysplasia of uncertain significance (IDUS), and their distinction from low risk MDS.
Valent P, Bain BJ, Bennett JM, Wimazal F, Sperr WR, Mufti G, Horny HP
Leuk Res 2012 Jan;36(1):1-5. Epub 2011 Sep 13 doi: 10.1016/j.leukres.2011.08.016. PMID: 21920601

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...