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Unresectable Anal Canal Squamous Cell Carcinoma

MedGen UID:
1784186
•Concept ID:
C5446482
•
Neoplastic Process

Definition

Anal canal squamous cell carcinoma that is not amenable to surgery. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Anal Canal Squamous Cell Carcinoma

Professional guidelines

PubMed

The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal.
Eng C, Chang GJ, You YN, Das P, Rodriguez-Bigas M, Xing Y, Vauthey JN, Rogers JE, Ohinata A, Pathak P, Sethi S, Phillips JK, Crane CH, Wolff RA
Oncotarget 2014 Nov 30;5(22):11133-42. doi: 10.18632/oncotarget.2563. PMID: 25373735Free PMC Article
Multimodality therapy including salvage surgical resection and intraoperative radiotherapy for patients with squamous-cell carcinoma of the anus with residual or recurrent disease after primary chemoradiotherapy.
Hallemeier CL, You YN, Larson DW, Dozois EJ, Nelson H, Klein KA, Miller RC, Haddock MG
Dis Colon Rectum 2014 Apr;57(4):442-8. doi: 10.1097/DCR.0000000000000071. PMID: 24608300

Recent clinical studies

Etiology

Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal.
Eng C, Chang GJ, You YN, Das P, Rodriguez-Bigas M, Xing Y, Vauthey JN, Rogers JE, Ohinata A, Pathak P, Sethi S, Phillips JK, Crane CH, Wolff RA
Oncotarget 2014 Nov 30;5(22):11133-42. doi: 10.18632/oncotarget.2563. PMID: 25373735Free PMC Article
Multimodality therapy including salvage surgical resection and intraoperative radiotherapy for patients with squamous-cell carcinoma of the anus with residual or recurrent disease after primary chemoradiotherapy.
Hallemeier CL, You YN, Larson DW, Dozois EJ, Nelson H, Klein KA, Miller RC, Haddock MG
Dis Colon Rectum 2014 Apr;57(4):442-8. doi: 10.1097/DCR.0000000000000071. PMID: 24608300
Epidermoid carcinoma of the anal canal. A series of 276 cases.
Papillon J, Montbarbon JF
Dis Colon Rectum 1987 May;30(5):324-33. doi: 10.1007/BF02555448. PMID: 3568920
Photodynamic therapy in patients with colorectal cancer.
Herrera-Ornelas L, Petrelli NJ, Mittelman A, Dougherty TJ, Boyle DG
Cancer 1986 Feb 1;57(3):677-84. doi: 10.1002/1097-0142(19860201)57:3<677::aid-cncr2820570347>3.0.co;2-v. PMID: 3943006

Diagnosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal.
Eng C, Chang GJ, You YN, Das P, Rodriguez-Bigas M, Xing Y, Vauthey JN, Rogers JE, Ohinata A, Pathak P, Sethi S, Phillips JK, Crane CH, Wolff RA
Oncotarget 2014 Nov 30;5(22):11133-42. doi: 10.18632/oncotarget.2563. PMID: 25373735Free PMC Article

Therapy

The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal.
Eng C, Chang GJ, You YN, Das P, Rodriguez-Bigas M, Xing Y, Vauthey JN, Rogers JE, Ohinata A, Pathak P, Sethi S, Phillips JK, Crane CH, Wolff RA
Oncotarget 2014 Nov 30;5(22):11133-42. doi: 10.18632/oncotarget.2563. PMID: 25373735Free PMC Article
Long survival of patients with unresectable cervical carcinoma after radiotherapy.
Sakata K, Hareyama M, Yama N, Oouchi A, Shido M, Nagakura H, Morita K, Kudo R
Jpn J Clin Oncol 1997 Aug;27(4):285-7. doi: 10.1093/jjco/27.4.285. PMID: 9379521
Epidermoid carcinoma of the anal canal. A series of 276 cases.
Papillon J, Montbarbon JF
Dis Colon Rectum 1987 May;30(5):324-33. doi: 10.1007/BF02555448. PMID: 3568920

Prognosis

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study.
Morris VK, Salem ME, Nimeiri H, Iqbal S, Singh P, Ciombor K, Polite B, Deming D, Chan E, Wade JL, Xiao L, Bekaii-Saab T, Vence L, Blando J, Mahvash A, Foo WC, Ohaji C, Pasia M, Bland G, Ohinata A, Rogers J, Mehdizadeh A, Banks K, Lanman R, Wolff RA, Streicher H, Allison J, Sharma P, Eng C
Lancet Oncol 2017 Apr;18(4):446-453. Epub 2017 Feb 18 doi: 10.1016/S1470-2045(17)30104-3. PMID: 28223062Free PMC Article
Multimodality therapy including salvage surgical resection and intraoperative radiotherapy for patients with squamous-cell carcinoma of the anus with residual or recurrent disease after primary chemoradiotherapy.
Hallemeier CL, You YN, Larson DW, Dozois EJ, Nelson H, Klein KA, Miller RC, Haddock MG
Dis Colon Rectum 2014 Apr;57(4):442-8. doi: 10.1097/DCR.0000000000000071. PMID: 24608300
Epidermoid carcinoma of the anal canal. A series of 276 cases.
Papillon J, Montbarbon JF
Dis Colon Rectum 1987 May;30(5):324-33. doi: 10.1007/BF02555448. PMID: 3568920

Clinical prediction guides

Prognostic and Predictive Markers for Patients With Anal Cancer.
Holliday EB, Peddireddy A, Morris VK
J Natl Compr Canc Netw 2023 Jun;21(6):678-684. doi: 10.6004/jnccn.2023.7031. PMID: 37308122
The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies.
Jácome AA, Morris VK, Eng C
Curr Treat Options Oncol 2022 Aug;23(8):1073-1085. Epub 2022 Jun 6 doi: 10.1007/s11864-022-00939-3. PMID: 35666353
Multimodality therapy including salvage surgical resection and intraoperative radiotherapy for patients with squamous-cell carcinoma of the anus with residual or recurrent disease after primary chemoradiotherapy.
Hallemeier CL, You YN, Larson DW, Dozois EJ, Nelson H, Klein KA, Miller RC, Haddock MG
Dis Colon Rectum 2014 Apr;57(4):442-8. doi: 10.1097/DCR.0000000000000071. PMID: 24608300

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