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Elevated circulating soluble CD25 concentration

MedGen UID:
1784407
•Concept ID:
C5539839
•
Finding
Synonym: Elevated circulating interleukin-2 receptor alpha-chain
 
HPO: HP:0033833

Definition

Increased concentration of the interleukin-2 receptor alpha-chain (CD25) in the blood circulation. CD25 is shed upon immune activation. Increased levels of soluble CD25, therefore, are an indication of an on-going immune response. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating soluble CD25 concentration

Recent clinical studies

Therapy

Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women.
Khorram O, Yeung M, Vu L, Yen SS
J Clin Endocrinol Metab 1997 Nov;82(11):3590-6. doi: 10.1210/jcem.82.11.4363. PMID: 9360512

Prognosis

Soluble interleukin 2 receptors in sera of Japanese patients with adult T cell leukemia mark activity of disease.
Yasuda N, Lai PK, Ip SH, Kung PC, Hinuma Y, Matsuoka M, Hattori T, Takatsuki K, Purtilo DT
Blood 1988 Apr;71(4):1021-6. PMID: 2895675

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